Mitochondria as a therapeutic target for cardiac ischemia‑reperfusion injury (Review).

Abstract:

:Acute myocardial infarction is the leading cause of cardiovascular‑related mortality and chronic heart failure worldwide. As regards treatment, the reperfusion of ischemic tissue generates irreversible damage to the myocardium, which is termed 'cardiac ischemia‑reperfusion (IR) injury'. Due to the large number of mitochondria in cardiomyocytes, an increasing number of studies have focused on the roles of mitochondria in IR injury. The primary causes of IR injury are reduced oxidative phosphorylation during hypoxia and the increased production of reactive oxygen species (ROS), together with the insufficient elimination of these oxidative species following reperfusion. IR injury includes the oxidation of DNA, incorrect modifications of proteins, the disruption of the mitochondrial membrane and respiratory chain, the loss of mitochondrial membrane potential (∆Ψm), Ca2+ overload, mitochondrial permeability transition pore formation, swelling of the mitochondria, and ultimately, cardiomyocyte necrosis. The present review article discusses the molecular mechanisms of IR injury, and summarizes the metabolic and dynamic changes occurring in the mitochondria in response to IR stress. The mitochondria are strongly recommended as a target for the development of therapeutic agents; however, the appropriate use of agents remains a challenge.

journal_name

Int J Mol Med

authors

Marin W,Marin D,Ao X,Liu Y

doi

10.3892/ijmm.2020.4823

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

485-499

issue

2

eissn

1107-3756

issn

1791-244X

journal_volume

47

pub_type

杂志文章
  • Role of the third intracellular loop and of the cytoplasmic tail in the mitogenic signaling of the protease-activated receptor 1.

    abstract::The activation of the protease-activated receptor 1 (PAR-1) by thrombin has been shown to induce an activation of the MAP kinase cascade and to stimulate cell proliferation. To examine the mechanisms of signal transduction by PAR-1, we constructed several PAR-1 mutants which were stably expressed in CHO cells. When co...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.8.3.309

    authors: Chen X,Berrou J,Vigneau C,Rondeau E

    更新日期:2001-09-01 00:00:00

  • Exendin-4 protects bone marrow-derived mesenchymal stem cells against oxygen/glucose and serum deprivation-induced apoptosis through the activation of the cAMP/PKA signaling pathway and the attenuation of ER stress.

    abstract::Exendin-4 (ex-4) is a long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist which exerts beneficial effects on glycemic control and promotes cell viability. In the present study, we investigated the anti-apoptotic effects of ex-4, as well as the potential mechanisms responsible for these effects in rat bone ma...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.2016.2509

    authors: He J,Wang C,Sun Y,Lu B,Cui J,Dong N,Zhang M,Liu Y,Yu B

    更新日期:2016-04-01 00:00:00

  • Signal transduction in human endothelial cells induced by their interaction with group B Streptococci.

    abstract::The molecular mechanisms underlying entry of group B Streptococci (GBS) into human endothelial cells are not yet fully understood. This study is centered on the triggering of signaling cascade in human umbilical vein endothelial cells (HUVEC) during their interaction with different GBS serotypes/strains (type III: 803...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:

    authors: Santos GS,Lione VO,Costa E Silva Filho F,Nagao PE

    更新日期:2005-05-01 00:00:00

  • (1)H nuclear magnetic resonance metabolomic analysis of mammary tumors from lean and obese Zucker rats exposed to 7,12-dimethylbenz[a]anthracene.

    abstract::Obesity increases mammary tumor development in Zucker rats following a single administration of the procarcinogen 7,12-dimenthylbenz(a)anthracene (DMBA). Fifty-day-old obese and lean female Zucker rats were orally gavaged with 65 mg/kg DMBA and sacrificed 139 days post DMBA treatment. At the end of the experiment, mam...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:

    authors: Whitehead TL,Holley AW,Korourian S,Shaaf S,Kieber-Emmons T,Hakkak R

    更新日期:2007-10-01 00:00:00

  • The effect of curcumin on the differentiation, apoptosis and cell cycle of neural stem cells is mediated through inhibiting autophagy by the modulation of Atg7 and p62.

    abstract::Curcumin is an orange-yellow colored, lipophilic polyphenol substance derived from the rhizome of Curcuma longa that is widely used in many countries. Curcumin has many reported functions, including antioxidant and anti‑inflammatory effects. Autophagy removes damaged organelles and protein aggregates in the cell. Howe...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.2018.3847

    authors: Wang JL,Wang JJ,Cai ZN,Xu CJ

    更新日期:2018-11-01 00:00:00

  • Observation of lymphatic vessels in orbital fat of patients with inflammatory conditions: a form fruste of lymphangiogenesis?

    abstract::In the absence of antibodies specific for lymphatic vessels, analysis of lymphatic vessels within different tissues has been widely performed with light microscopic and, most importantly, electron microscopic techniques. In regard to lymphatic vessels in the ocular globe and the periocular structures, controversy rema...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.13.5.681

    authors: Fogt F,Zimmerman RL,Daly T,Gausas RE

    更新日期:2004-05-01 00:00:00

  • Bax gene disruption alters the epidermal response to ultraviolet irradiation and in vivo induced skin carcinogenesis.

    abstract::Bcl-2 family member proteins are differentially expressed in skin and in non-melanoma skin cancer (NMSC). To elucidate the contribution of bcl-2 and bax proteins to epidermal differentiation and skin carcinogenesis, we investigated keratinocyte proliferation, differentiation and tumourigenesis in bcl-2(-/-) and bax(-/...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.7.3.235

    authors: Cho SH,Delehedde M,Rodriguez-Villanueva J,Brisbay S,McDonnell TJ

    更新日期:2001-03-01 00:00:00

  • A novel autoantibody in paraneoplastic sensory-dominant neuropathy reacts with brain-type creatine kinase.

    abstract::We have previously reported on a novel autoantibody in a patient with paraneoplastic sensory-dominant neuropathy. This autoantibody immunostains the rat primary sensory system and reacts with a 47 kDa protein on immunoblotting. Here, we report on the isolation from rat spinal cord of a molecule that is recognized by t...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.1.3.597

    authors: Arawaka S,Daimon M,Sasaki H,Suzuki JI,Kato T

    更新日期:1998-03-01 00:00:00

  • Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells.

    abstract::Epidemiological studies have indicated that increased consumption of cruciferous vegetables is associated with a statistically significant reduction in the risk for cancers. The major bioactive agent in these vegetables is a class of sulfur-containing glycosides called glucosinolates. Isothiocyanates, derivatives of g...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:

    authors: Jadhav U,Ezhilarasan R,Vaughn SF,Berhow MA,Mohanam S

    更新日期:2007-03-01 00:00:00

  • Involvement of endoplasmic reticulum stress-associated apoptosis in a heart failure model induced by chronic myocardial ischemia.

    abstract::Apoptosis plays a critical role in the pathogenesis of chronic myocardial ischemia (CMI) and heart failure (HF). Endoplasmic reticulum stress (ERS) is one of the newly defined signaling pathways which initiate apoptosis. Previous studies have shown that ERS-associated apoptosis is involved in the pathogenesis of HF in...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.2011.612

    authors: Xin W,Li X,Lu X,Niu K,Cai J

    更新日期:2011-04-01 00:00:00

  • Monoclonal antibody against Toll-like receptor 4 attenuates ventilator-induced lung injury in rats by inhibiting MyD88- and NF-κB-dependent signaling.

    abstract::The mechanisms through which mechanical ventilation causes non-infectious inflammatory diseases and lung injury are poorly understood. Animals models of this type of injury suggest that it involves signaling mediated by Toll‑like receptor (TLR)4 and 9. In this study, in order to gain further insight into the involveme...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.2017.2873

    authors: Huang C,Pan L,Lin F,Dai H,Fu R

    更新日期:2017-03-01 00:00:00

  • Adipose tissue-derived stem cells attenuate acute lung injury through eNOS and eNOS-derived NO.

    abstract::Acute lung injury (ALI) is among the most common causes of mortality in intensive care units. Recent in vivo and in vitro studies have suggested that mesenchymal stem cells (MSCs) attenuate pulmonary edema and inflammatory factors, but the mechanisms of the effects of MSCs on pulmonary vascular function remain unknown...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.2013.1328

    authors: Gao P,Yang X,Mungur L,Kampo S,Wen Q

    更新日期:2013-06-01 00:00:00

  • Gastrodin inhibits cell proliferation in vascular smooth muscle cells and attenuates neointima formation in vivo.

    abstract::Vascular smooth muscle cell (VSMC) proliferation plays a critical role in the development of vascular diseases. In the present study, we tested the efficacy and the mechanisms of action of gastrodin, a bioactive component of the Chinese herb Gastrodia elata Bl, in relation to platelet-derived growth factor-BB (PDGF-BB...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.2012.1100

    authors: Zhu L,Guan H,Cui C,Tian S,Yang D,Wang X,Zhang S,Wang L,Jiang H

    更新日期:2012-11-01 00:00:00

  • Propofol‑induced HOXA11‑AS promotes proliferation, migration and invasion, but inhibits apoptosis in hepatocellular carcinoma cells by targeting miR‑4458.

    abstract::Propofol is a commonly used drug for the induction and maintenance of anesthesia. Previous studies have reported that propofol is involved in the progression of numerous human cancer types, including hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms in HCC are yet to be elucidated. The prese...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.2020.4667

    authors: Song F,Liu J,Feng Y,Jin Y

    更新日期:2020-09-01 00:00:00

  • Prevalence of the C282Y and H63D polymorphisms in a multi-ethnic control population.

    abstract::Recently a candidate gene for hereditary hemo-chromatosis, HFE, was identified. The finding raises the possibility for genetic testing to provide earlier detection and more complete genotypic evaluation of hemochromatosis affected individuals. We determined the frequency of the HFE polymorphisms, C282Y and H63D, in a ...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.4.4.389

    authors: Marshall DS,Linfert DR,Tsongalis GJ

    更新日期:1999-10-01 00:00:00

  • CDC25A inhibition suppresses the growth and invasion of human hepatocellular carcinoma cells.

    abstract::CDC25A is a cell cycle-activating phosphatase that promotes transition from the G1 to S phase. We previously reported that overexpression of CDC25A in human hepatocellular carcinoma (HCC) tissue samples was associated with poor prognosis. In this study, we attempted suppression of CDC25A in HCC cells to elucidate the ...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:

    authors: Xu X,Yamamoto H,Liu G,Ito Y,Ngan CY,Kondo M,Nagano H,Dono K,Sekimoto M,Monden M

    更新日期:2008-02-01 00:00:00

  • Deletion of Sema4D gene reduces intimal neovascularization and plaque growth in apolipoprotein E-deficient mice.

    abstract::Neovascularization occurring in atherosclerotic plaque leads to acceleration of plaque growth through increased leukocyte infiltration and reactive oxygen species (ROS) production. Sema4D (CD100), a class IV semaphorin, not only plays a crucial role in axon guidance but also functions in the neovascularization process...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm_00000432

    authors: Yukawa K,Tanaka T,Kishino M,Yoshida K,Takeuchi N,Ito T,Takamatsu H,Kikutani H,Kumanogoh A

    更新日期:2010-07-01 00:00:00

  • Flap endonuclease 1 is a promising candidate biomarker in gastric cancer and is involved in cell proliferation and apoptosis.

    abstract::As a DNA repair protein, flap endonuclease 1 (FEN1), a structure-specific 5' nuclease, plays pivotal roles in the maturation of Okazaki fragments, long-patch base excision repair, restarting of stalled replication forks and telomere maintenance. FEN1 possesses 5' endonuclease, 5' exonuclease and gap-endonuclease activ...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.2014.1682

    authors: Wang K,Xie C,Chen D

    更新日期:2014-05-01 00:00:00

  • In vitro cell behaviors of bone mesenchymal stem cells derived from normal and postmenopausal osteoporotic rats.

    abstract::Postmenopausal osteoporosis (PMO) increases bone fragility and the risk of fractures, and impairs the healing procedure of bone defects in aged women. The stromal cell‑derived factor-1α (SDF-1α)/CXC chemokine receptor type 4 (CXCR4) axis helps to maintain the biological and physiological functions of bone marrow mesen...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.2017.3280

    authors: Liu Q,Zhang X,Jiao Y,Liu X,Wang Y,Li SL,Zhang W,Chen FM,Ding Y,Jiang C,Jin Z

    更新日期:2018-02-01 00:00:00

  • Effects of vitamin D receptor gene polymorphisms on low-resistance training using exercise machines: the 'Power Rehabilitation' program.

    abstract::The enhancement and promotion of health is necessary to maintain the quality of life (QOL) of the aged population in developed nations such as Japan where the number of elderly has been increasing rapidly. For this purpose, low-resistance training using exercise machines ('Power Rehabilitation') has been established a...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:

    authors: Murakami S,Otsuki T,Maeda M,Miura Y,Morii S,Kiyokane K,Hayakawa S,Maeda A,Imakawa T,Harada S,Handa T,Nishimura Y,Murakami S,Kumagai N,Hayashi H,Chen Y,Suemori S,Fukushima Y,Nishida S,Fukushima K

    更新日期:2009-01-01 00:00:00

  • Recruitment of mesenchymal stem cells by stromal cell-derived factor 1α in pulp cells from deciduous teeth.

    abstract::Dental pulp cells (DPCs), including dental pulp (DP) stem cells, play a role in dentine repair under certain conditions caused by bacterial infections associated with caries, tooth fracture and injury. Mesenchymal stem cells (MSCs) have also been shown to be involved in this process of repair. However, the mechanisms ...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.2015.2247

    authors: Akazawa Y,Hasegawa T,Yoshimura Y,Chosa N,Asakawa T,Ueda K,Sugimoto A,Kitamura T,Nakagawa H,Ishisaki A,Iwamoto T

    更新日期:2015-08-01 00:00:00

  • Cloning of a rat-specific long PCP4/PEP19 isoform.

    abstract::We report the identification of a cDNA that encodes a putative protein of 94 amino acids and expected molecular weight of 10.7 kDa, the C-terminal half of which is identical to that of PEP19, a small, brain-specific protein involved in Ca++/calmodulin signaling. The novel rat-specific protein, tentatively named long P...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:

    authors: Sala A,Scaturro M,Proia P,Schiera G,Balistreri E,Aflalo-Rattenbach R,Créau N,Di Liegro I

    更新日期:2007-03-01 00:00:00

  • Mechanism of HMGB1 release inhibition from RAW264.7 cells by oleanolic acid in Prunus mume Sieb. et Zucc.

    abstract::High mobility group box-1 protein (HMGB1), primarily from the nucleus, is released into the extracellular milieu either passively from necrotic cells or actively through secretion by monocytes/macrophages. Extracellular HMGB1 acts as a potent inflammatory agent by promoting the release of cytokines such as tumor necro...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm_00000172

    authors: Kawahara K,Hashiguchi T,Masuda K,Saniabadi AR,Kikuchi K,Tancharoen S,Ito T,Miura N,Morimoto Y,Biswas KK,Nawa Y,Meng X,Oyama Y,Takenouchi K,Shrestha B,Sameshima H,Shimizu T,Adachi T,Adachi M,Maruyama I

    更新日期:2009-05-01 00:00:00

  • The calcium-sensing receptor and vitamin D receptor expression in tertiary hyperparathyroidism.

    abstract::The parathormone (PTH) production is controlled by calcium and vitamin D, which interact with the calcium-sensing receptor (CaSR) and vitamin D receptor (VDR), respectively. All of these elements control calcium homeostasis, which is crucial for many physiological processes. Thus, impairment of the upstream component ...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:

    authors: Grzela T,Chudzinski W,Lasiecka Z,Niderla J,Wilczynski G,Gornicka B,Wasiutynski A,Durlik M,Boszczyk A,Brawura-Biskupski-Samaha R,Dziunycz P,Milewski L,Lazarczyk M,Lazarczyk M,Nawrot I

    更新日期:2006-05-01 00:00:00

  • Adenovirus-mediated P311 ameliorates renal fibrosis through inhibition of epithelial-mesenchymal transition via TGF-β1-Smad-ILK pathway in unilateral ureteral obstruction rats.

    abstract::Epithelial-mesenchymal transition (EMT) is a critical step and key factor during renal fibrosis. Preventing renal tubular EMT is important for delaying the progression of chronic kidney disease (CKD). P311, a highly conserved 8-kDa intracellular protein, has been indicated as an important factor in myofibroblast trans...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.2018.3485

    authors: Qi FH,Cai PP,Liu X,Si GM

    更新日期:2018-05-01 00:00:00

  • Sodium selenite inhibits leukemia HL-60 cell proliferation and induces cell apoptosis by enhancing the phosphorylation of JNK1 and increasing the expression of p21 and p27.

    abstract::Selenium is an essential trace element and has shown chemopreventive or therapeutic activities on human solid cancers; however, whether it has anticancer effects on leukemia has not yet been elucidated. The present study was designed to determine the role of selenium on HL-60 human promyelocytic leukemia cells. We fou...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.2014.1854

    authors: Wu S,Bao Y,Ma D,Zi Y,Yang C,Yang M,Xing M,Yang W

    更新日期:2014-10-01 00:00:00

  • Penehyclidine hydrochloride alleviates lipopolysaccharide‑induced acute lung injury in rats: Potential role of caveolin‑1 expression upregulation.

    abstract::The aim of the present study was to examine the protective effect of caveolin‑1 (Cav‑1) in the penehyclidine hydrochloride (PHC)‑based inhibition of lipopolysaccharide (LPS)‑induced acute lung injury (ALI) in vivo and in vitro, in addition to the potential underlying mechanisms. In vivo, an ALI rat model was establish...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.2019.4117

    authors: Wu X,Kong Q,Xia Z,Zhan L,Duan W,Song X

    更新日期:2019-05-01 00:00:00

  • Sulforaphane suppresses the viability and metastasis, and promotes the apoptosis of bladder cancer cells by inhibiting the expression of FAT‑1.

    abstract::FAT atypical cadherin 1 (FAT1) regulates complex mechanisms for the promotion of oncogenesis or the suppression of malignancies. Sulforaphane (SFN) has antioxidant and anti‑tumor activities. The present study investigated the roles of SFN and FAT1 in bladder cancer (BC). The expression of FAT1 in BC cell lines and tis...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.2020.4665

    authors: Wang F,Liu P,An H,Zhang Y

    更新日期:2020-09-01 00:00:00

  • Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis.

    abstract::Histone deacetylase inhibitor (HDAI) induces accumulation of highly acetylated histones by inhibiting the activity of histone deacetylase and inhibits cell proliferation, induces differentiation, and promotes apoptosis. TNF-related apoptosis inducing ligand (TRAIL) induces apoptosis in various human cancer cells, a pr...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:

    authors: Inoue H,Shiraki K,Ohmori S,Sakai T,Deguchi M,Yamanaka T,Okano H,Nakano T

    更新日期:2002-05-01 00:00:00

  • Angiopoietin-2 promotes extracellular matrix degradation in human degenerative nucleus pulposus cells.

    abstract::In contrast to healthy intervertebral discs (IVDs), degenerate IVDs become vascularized. Here, we determined the role of an angiogenesis promoter, angiopoietin (Ang)-2, in the pathology of IVD degeneration (IDD). We evaluated degree of IDD using the Pfirrmann grading system. We used quantitative real-time polymerase c...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章

    doi:10.3892/ijmm.2018.3576

    authors: Wang K,Kang L,Liu W,Song Y,Wu X,Zhang Y,Hua W,Zhao K,Li S,Tu J,Luo R,Yang C

    更新日期:2018-06-01 00:00:00