MicroRNA-153 suppresses the osteogenic differentiation of human mesenchymal stem cells by targeting bone morphogenetic protein receptor type II.

abstract：:Periodontal disease is characterized by inflammation and bone loss. The balance between inflammatory mediators and their counter-regulatory molecules may be fundamental for determining the outcome of the immune pathology of periodontal disease. Transforming growth factor-β (TGF-β) and vascular endothelial growth facto...

journal_title：International journal of molecular medicine

authors： Matarese G,Isola G,Anastasi GP,Favaloro A,Milardi D,Vermiglio G,Vita G,Cordasco G,Cutroneo G

更新日期：2012-09-01 00:00:00

abstract：:Solute carrier family 26, member 3 (Slc26a3), also termed downregulated-in-adenoma (DRA) is a member of the Slc26 family of anion transporters and is mutated in congenital chloride diarrhea. Our previous study demonstrated that DRA deficiency is associated with severely reduced colonic HCO3‑ secretion, a loss of colon...

journal_title：International journal of molecular medicine

authors： Ding X,Li D,Li M,Tian D,Yu H,Yu Q

更新日期：2018-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) have important effects on cancer occurrence and development by adjusting gene expression. The aim of the present study was to examine the role of miR‑214 in papillary thyroid carcinoma cell proliferation and metastasis, and its molecular mechanisms. miR‑214 was demonstrated to be markedly downregula...

journal_title：International journal of molecular medicine

authors： Liu F,Lou K,Zhao X,Zhang J,Chen W,Qian Y,Zhao Y,Zhu Y,Zhang Y

更新日期：2018-12-01 00:00:00

abstract：:ACSL3 is a member of the long chain acyl-CoA synthetase (ACSL) family that consists of 5 isozymes responsible for cellular fatty acid metabolism in various tissues in an isozyme-specific manner. Our previous studies have demonstrated that expression of ACSL3 mRNA and protein in liver was specifically increased after f...

journal_title：International journal of molecular medicine

authors： Wu M,Cao A,Dong B,Liu J

更新日期：2011-05-01 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) has been suggested to be a putative tumor promoter gene, and autocrine of TNF-α expression has been found in colon cancer and ovarian cancer. As the role of autocrine TNF-α in human gallbladder cancer has not yet been elucidated, the present study examined the expression of TNF-α in gal...

journal_title：International journal of molecular medicine

authors： Zhu G,Du Q,Wang X,Tang N,She F,Chen Y

更新日期：2014-06-01 00:00:00

abstract：:The dysregulation of microRNA‑939‑5p (miR‑939) is involved in the development of multiple types of human cancer. However, the expression and roles of miR‑939 in osteosarcoma (OS) have yet to be clarified. The expression level of miR‑939 in OS was measured using reverse transcription quantitative polymerase chain react...

journal_title：International journal of molecular medicine

authors： Zhao X,Li J,Yu D

更新日期：2019-11-01 00:00:00

abstract：:The transcription factor nuclear factor-κB (NF-κB) has been shown to function as a key regulator of cell death or survival in neuronal cells. Previous studies indicate that the biphasic activation of NF-κB occurs following experimental neonatal hypoxia-ischemia and subarachnoid hemorrhage. However, the comprehensive u...

journal_title：International journal of molecular medicine

authors： Zhang H,Zhang D,Li H,Yan H,Zhang Z,Zhou C,Chen Q,Ye Z,Hang C

更新日期：2018-06-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is a rare aggressive type of B-cell non-Hodgkin's lymphoma. Response to chemotherapy tends to be short and virtually all patients sooner or later relapse. The prognosis of relapsed patients is extremely poor. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered o...

journal_title：International journal of molecular medicine

authors： Pospisilova J,Vit O,Lorkova L,Klanova M,Zivny J,Klener P,Petrak J

更新日期：2013-05-01 00:00:00

abstract：:Platelet-rich plasma (PRP) is used in the clinic as an autologous blood product to stimulate bone regeneration and chondrogenesis. Numerous studies have demonstrated that PRP affects bone remodeling by accelerating osteoblast formation. With the research perspective focusing on osteoclasts, the present study establish...

journal_title：International journal of molecular medicine

authors： Wang D,Weng Y,Guo S,Zhang Y,Zhou T,Zhang M,Wang L,Ma J

更新日期：2018-02-01 00:00:00

abstract：:Radix Astragali (RA) is widely used in traditional Chinese medicine (TCM), and astragaloside IV (AS‑IV) is the most critical component of RA. Previous studies have demonstrated that AS‑IV exerts effects on the myocardium, nervous system and endocrine system, among others. In the present review article, data from studi...

journal_title：International journal of molecular medicine

authors： Chen T,Yang P,Jia Y

更新日期：2021-03-01 00:00:00

abstract：:Chronic hepatitis B (CHB) virus infection is caused by compromised host immunity, but the precise underlying mechanism remains unclear. Retinoic acid-inducible gene I (RIG-I) triggers antiviral immunity by inducing interferon-β (IFN-β) production following viral infection. To investigate the role of the RIG-I-IFN-β si...

journal_title：International journal of molecular medicine

authors： Zhao G,An B,Zhou H,Wang H,Xu Y,Xiang X,Dong Z,An F,Yu D,Wang W,Bao S,Xie Q

更新日期：2012-12-01 00:00:00

abstract：:Molecular defects of TNFRSF1A was investigated in members of a family presenting with typical phenotypes of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) and in patients with the autoimmune disorders, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Genomic DNA from the members o...

journal_title：International journal of molecular medicine

authors： Horiuchi T,Tsukamoto H,Mitoma H,Miyagawa H,Tamimoto Y,Yoshizawa S,Harada M,Hayashi K,Hashimura C,Oribe M,Okamura S

更新日期：2004-11-01 00:00:00

abstract：:Previously, a specific angiogenesis inhibitor, angiostatin, discovered in urine and serum of tumor-bearing mice, was reported to potently block tumor growth and metastasis in animal models. Detection of angiostatin and its precursor proteins in urine from cancer patients has not been reported. Now, we report the devel...

journal_title：International journal of molecular medicine

authors： Cao Y,Veitonmaki N,Keough K,Cheng H,Lee LS,Zurakowski D

更新日期：2000-05-01 00:00:00

abstract：:The present study aimed to develop a tumor necrosis factor‑α (TNF‑α) B‑cell epitope/IL‑1β helper T lymphocyte epitope complex MAP vaccine for the alleviation of ulcerative colitis (UC) in mice. The B cell epitopes of murine TNF‑α (mTNF‑α) were predicted in silico and coupled with the universal interleukin 1β (IL‑1β) h...

journal_title：International journal of molecular medicine

authors： Sun Y,Pan W,Zhang J,Cui Y,Wang H,Ru G,Chen L

更新日期：2019-09-01 00:00:00

abstract：:Cancer stem cells (CSCs) have recently been linked to new treatment strategies for gastric cancer due to the critical role which they play as the 'heartbeat' of cancer. In the present study, we explored the effects of quercetin, an anti-inflammatory and antiviral compound, on gastric CSCs (GCSCs). We noted that quercet...

journal_title：International journal of molecular medicine

authors： Shen X,Si Y,Wang Z,Wang J,Guo Y,Zhang X

更新日期：2016-08-01 00:00:00

abstract：:Influenza is the most common infectious disease and is caused by influenza A virus (IAV) infection. Hemagglutinin (HA) is an important viral protein of influenza A and is a major component of current IAV vaccines. The side effects associated with IAV vaccination are well studied; however, the HA‑induced immunopatholog...

journal_title：International journal of molecular medicine

authors： Li Y,Hu H,Qi Z,Sun J,Li Y,Feng Q,Guo C,Wang H,Zhao P,Liu Y,Zhao X,Wang G,Zhang H,Liu L,Hu J

更新日期：2018-03-01 00:00:00

abstract：:The prevalence of psoriasis is increasing, and poses a serious risk to human health and quality of life. Psoriasis, a chronic immune‑mediated skin disease with epidermal hyperkeratosis and parakeratosis, is associated with numerous complications, including metabolic syndromes that are regulated by sirtuins (SIRTs) via...

journal_title：International journal of molecular medicine

authors： Fan X,Yan K,Meng Q,Sun R,Yang X,Yuan D,Li F,Deng H

更新日期：2019-07-01 00:00:00

abstract：:Rats exposed from 7 weeks after birth and for the ensuing 3 to 7 months to a diet depleted in long-chain polyunsaturated omega3 fatty acids were recently proposed as a new animal model for the metabolic syndrome. The present study aimed mainly at investigating whether, in this new model, the perturbation of the fatty ...

journal_title：International journal of molecular medicine

authors： Portois L,Hacquebard M,Malaisse WJ,Carpentier YA

更新日期：2009-08-01 00:00:00

abstract：:The spindle checkpoint proteins (SCPs), which sense the existence of misaligned sister chromatids during mitosis and meiosis, are essential for cell proliferation and differentiation. Therefore, the role of SCPs in carcinogenesis is gaining increased attention. In this study, we ana...

journal_title：International journal of molecular medicine

authors： Liao S,Deng D,Hu X,Wang W,Li L,Li W,Zhou J,Xu G,Meng L,Wang S,Ma D

更新日期：2013-01-01 00:00:00

abstract：:The DAL-1/41B gene (differentially expressed in adenocarcinoma of the lung), located in the chromosome 18p11.3 region, belongs to the protein family 4.1 (membrane-associated proteins), which includes the product of the NF2 gene (merlin), and the proteins, ezrin, radixin, and moesin. DAL-1/4.1B is normally expressed at...

journal_title：International journal of molecular medicine

authors： Martinez-Glez V,Bello MJ,Franco-Hernandez C,De Campos JM,Isla A,Vaquero J,Rey JA

更新日期：2005-10-01 00:00:00

abstract：:We have recently established a clonal mesenchymal stem cell line (rBM25/S3) from adult rat bone marrow. The cells have practically unlimited proliferation capacity (over 300 PDL), maintaining multipotency for differentiation. In the present study, we examined the potential for rBM25/S3 cells to differentiate into insu...

journal_title：International journal of molecular medicine

authors： Masaka T,Miyazaki M,Du G,Hardjo M,Sakaguchi M,Takaishi M,Kataoka K,Yamamoto K,Huh NH

更新日期：2008-10-01 00:00:00

abstract：:Cartilage tissue engineering plays an important role in the generation of grafts for reconstructive surgery. In cultured chondrocytes, the dedifferentiation of cells seems unavoidable for multiplication. Dedifferentiated cells produce matrix of less quality, and the molecular basis is still not well understood. Theref...

journal_title：International journal of molecular medicine

authors： Goessler UR,Bieback K,Bugert P,Naim R,Schafer C,Sadick H,Hormann K,Riedel F

更新日期：2005-10-01 00:00:00

abstract：:We evaluated the postoperative adjuvant chemotherapy by UFT using the primary tumor amputation-pulmonary metastasis model. When Lewis lung carcinoma (LLC) primary tumors on the hind foot pad grew palpable, they were amputated on two different days. In experiment (A) (earlier amputation model), micrometastases were det...

journal_title：International journal of molecular medicine

authors： Uchida J,Sato K,Okabe H,Saito H,Nakano K,Fujioka A,Takechi T,Takeda S,Unemi N,Fukushima M

更新日期：2000-04-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of microRNA (miR)‑142‑3p on neuropathic pain caused by sciatic nerve injury in chronic compression injury (CCI) rats, and further investigate its mechanism. Rat experiments were divided into four parts in the study. In the first part, the rats were divided in...

journal_title：International journal of molecular medicine

authors： Li X,Wang S,Yang X,Chu H

更新日期：2021-02-01 00:00:00

abstract：:Human serum amyloid P (hSAP), a member of the pentraxin family, inhibits the activation of fibrocytes in culture and inhibits experimental renal, lung, skin and cardiac fibrosis. As hepatic inflammation is one of the causes of liver fibrosis, in the present study, we investigated the hepatoprotective effects of hSAP a...

journal_title：International journal of molecular medicine

authors： Cong M,Zhao W,Liu T,Wang P,Fan X,Zhai Q,Bao X,Zhang D,You H,Kisseleva T,Brenner DA,Jia J,Zhuang H

更新日期：2017-08-01 00:00:00

abstract：:The ZNF268 gene was originally isolated from an early human embryo cDNA library. Several different transcripts have been isolated for the ZNF268 gene and developmental expression studies suggest that ZNF268 plays a role in the development of human fetal liver and the differentiation of blood cells. In our effort to st...

journal_title：International journal of molecular medicine

authors： Shao H,Zhu C,Zhao Z,Guo M,Qiu H,Liu H,Wang D,Xue L,Gao L,Sun C,Li W

更新日期：2006-09-01 00:00:00

abstract：:Death-associated protein kinase (DAPK) is a Ca2+/calmodulin-dependent serine/threonine kinase that is thought to mediate apoptosis. We have shown that the kinase domain of DAPK is crucial for the induction of renal tubular cell apoptosis in chronic obstructive uropathy (COU) created by unilateral ureteral ligation. DA...

journal_title：International journal of molecular medicine

authors： Yukawa K,Kishino M,Hoshino K,Shirasawa N,Kimura A,Tsubota Y,Owada-Makabe K,Bai T,Tanaka T,Ueyama T,Ichinose M,Takeda K,Akira S,Maeda M

更新日期：2005-01-01 00:00:00

abstract：:Annexin A9 (ANXA9), a member of annexin family, has been reported be associated with colorectal cancer (CRC) carcinogenesis. However, the clinical significance of ANXA9 in CRC, particularly its correlation to invasion and metastasis remains ambiguous. The aim of the present study was to investigate the significance of...

journal_title：International journal of molecular medicine

authors： Yu S,Bian H,Gao X,Gui L

更新日期：2018-04-01 00:00:00

abstract：:Human immunodeficiency virus type-1 (HIV-1) transcription is dependent on the interaction of host-cell transcription factors with cis-regulatory DNA elements within the viral long terminal repeat (LTR). Much attention has focused on the series of sequence elements upstream of the transcriptional initiation site in the...

journal_title：International journal of molecular medicine

authors： Al-Harthi L,Roebuck KA

更新日期：1998-05-01 00:00:00

abstract：:The present study aimed to explore the underlying mechanisms of bone morphogenetic protein 2 (BMP2) in alleviating intervertebral disc degeneration (IDD). A rat puncture IDD model was constructed, and the rats were randomly divided into six groups: Control; IDD (model); IDD+PBS [containing 1010 adeno‑associated virus ...

journal_title：International journal of molecular medicine

authors： Tan Y,Yao X,Dai Z,Wang Y,Lv G

更新日期：2019-01-01 00:00:00