Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells.

abstract：:Adiponectin (APN) exerts anti‑inflammatory effects in various cells. Uric acid (UA) induces inflammation in proximal renal tubular epithelial cells (PTECs). It remains unknown whether APN protects against UA‑induced inflammation. In the present study, human PTECs were incubated with 100 µg/ml soluble (S) UA in the pre...

journal_title：International journal of molecular medicine

authors： Yang Q,Fu C,Zhang X,Zhang Z,Zou J,Xiao J,Ye Z

更新日期：2019-03-01 00:00:00

abstract：:D-mannoheptulose was recently proposed as a tool to label preferentially insulin-producing cells in the pancreatic gland in the perspective of the non-invasive imaging of the endocrine pancreas. In such a perspective, we have now synthesized 1-deoxy-1-[125I]iodo-D-mannoheptulose ([125I]MH) and examined its uptake by d...

journal_title：International journal of molecular medicine

authors： Sener A,Bessieres B,Courtois P,Ladriere L,Louchami K,Jijakli H,Malaisse WJ

更新日期：2001-05-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of impaired vision and blindness in the aging population. The aims of our studies were to identify qualitative and quantitative alterations in mitochondria in human retinal pigment epithelium (RPE) from AMD patients and con...

journal_title：International journal of molecular medicine

authors： Bianchi E,Scarinci F,Ripandelli G,Feher J,Pacella E,Magliulo G,Gabrieli CB,Plateroti R,Plateroti P,Mignini F,Artico M

更新日期：2013-01-01 00:00:00

abstract：:Substantial evidence has indicated that osteoblastic differentiation may be regulated by mechanical loads or bone morphogenetic protein-2 (BMP-2). BMP-2-induced in vivo osteogenesis can be significantly enhanced in the presence of mechanical stimuli, revealing the therapeutic potential of the combined application of B...

journal_title：International journal of molecular medicine

authors： Zeng Z,Yin X,Zhang X,Jing D,Feng X

更新日期：2015-11-01 00:00:00

abstract：:The pathogenesis of inflammatory bowel disease (IBD) remains unknown. It has been suggested that luminal factors such as the microflora, short chain fatty acids (SCFAs), food antigens and so on play important roles in the disease progression. Many reports have revealed alterations in the SCFA and organic acid concentr...

journal_title：International journal of molecular medicine

authors： Araki Y,Andoh A,Fujiyama Y,Itoh A,Bamba T

更新日期：2002-06-01 00:00:00

abstract：:The adaptive response of skeletal muscle fibres depends on a variety of biological factors including loading conditions and neuromuscular activity. An extreme type of atrophy-inducing change in contractile activity is represented by the physical disconnection between the motor nerve and its respective fibre unit. Sinc...

journal_title：International journal of molecular medicine

authors： Donoghue P,Ribaric S,Moran B,Cebasek V,Erzen I,Ohlendieck K

更新日期：2004-06-01 00:00:00

abstract：:Non‑small cell lung carcinoma (NSCLC) is a life‑threatening malignancy. The level of the cell growth regulator mitogen‑activated protein kinase kinase kinase kinase 3 (MAP4K3) has been shown to be correlated with a high risk of NSCLC recurrence and poor recurrence‑free survival rate. The present study examined the eff...

journal_title：International journal of molecular medicine

authors： Zhou Y,Hong T,Tong L,Liu W,Yang X,Luo J,Wang F,Li J,Yan L

更新日期：2018-12-01 00:00:00

abstract：:Soy sauce (Shoyu) is a traditional fermented seasoning of Japan and available throughout the world. Polysaccharides were obtained from dialysate of Shoyu, and these Shoyu polysaccharides (SPS) were examined for anti-allergic activity in vitro and in vivo. The SPS originated from partially-degraded polysaccharides of s...

journal_title：International journal of molecular medicine

authors： Kobayashi M,Matsushita H,Yoshida K,Tsukiyama R,Sugimura T,Yamamoto K

更新日期：2004-11-01 00:00:00

abstract：:Regulation of the murine Ret gene has only been partially studied, specifically cis-acting promoter elements and related transcription factors, although in vivo experiments have shown the ability of Ret 5' flanking sequences to drive expression of transgenic reporter genes. This work describes the characterization of ...

journal_title：International journal of molecular medicine

authors： Zordan P,Ravazzolo R,Bocciardi R

更新日期：2005-08-01 00:00:00

abstract：:We have previously reported comparative genomics analyses on FGF3, FGF4, FGF6, FGF7, FGF8, FGF10, FGF11, FGF17, FGF18, FGF19, FGF20, FGF22 and FGF23 genes. Here, we performed comparative genomics analyses on FGF1, FGF2, FGF5, FGF9, FGF12, FGF13, FGF14, FGF16 and FGF21 genes, and further characterized the FGF16 gene. C...

journal_title：International journal of molecular medicine

authors： Katoh Y,Katoh M

更新日期：2005-11-01 00:00:00

abstract：:Stannous ion, as a chloride salt, influenced on the survival and adhesive properties of two toxigenic Corynebacterium diphtheriae of the sucrose-fermenting (241 strain) and non-sucrose-fermenting (CDC-E8392 strain) biotypes. Differences in survival fractions suggested differences in susceptibility of strains to bacter...

journal_title：International journal of molecular medicine

authors： Silva De Souza SM,Hirata R Jr,Moreira LO,Gomes ML,Braga De Andrade AF,Bernardo-Filho M,Mattos-Guaraldi AL

更新日期：2003-10-01 00:00:00

abstract：:S100A4, one of the tandemly arranged S100 genes at chromosome 1q21, has been suggested to play a functional role in cell motility and invasiveness of tumor cell growth. We investigated the expression of S100A4 and the in vitro invasiveness of 4 human bile duct adenocarcinoma cell lines by the Matrigel assay. S100A4 wa...

journal_title：International journal of molecular medicine

authors： Katayama N,Murao S,Ajiki T,Kitazawa S,Onoyama H,Kuroda Y,Maeda S

更新日期：2000-11-01 00:00:00

abstract：:Thrombospondin-1 (TSP-1) is a naturally occurring anti-angiogenic compound that induces apoptosis of endothelial and cancer cells via its receptor CD36. The objectives of our study were to investigate the in vitro effects of TSP-1 on the apoptosis of primary human leukemia cells as well as leukemia cell lines and the ...

journal_title：International journal of molecular medicine

authors： Li K,Yang M,Yuen PM,Chik KW,Li CK,Shing MM,Lam HK,Fok TF

更新日期：2003-12-01 00:00:00

abstract：:We have previously reported that the EVn-50 mixture of vitexins (lignan compounds) containing the purified vitexin (neolignan) compound, 6-hydroxy-4(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl‑7-methoxy-3,4-dihydro-2-naphthaldehyde, termed VB1, exhibits potent anticancer activity through the induction of apoptosis in s...

journal_title：International journal of molecular medicine

authors： Liu LH,Zhou YJ,Ding L,Zhang SZ,Sun J,Cao JG

更新日期：2014-02-01 00:00:00

abstract：:CREB binding protein (CBP) plays a central role in cell differentiation and proliferation, interacting with a large number of nuclear factors. To find novel nuclear factors associating with CBP, we have carried out yeast two-hybrid screening of human chondrocyte cDNA library using the C/H3 region of CBP as a bait and ...

journal_title：International journal of molecular medicine

authors： Hirose T,Fujii R,Nakamura H,Aratani S,Fujita H,Nakazawa M,Nakamura K,Nishioka K,Nakajima T

更新日期：2003-06-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) play an important role in the tumorigenesis and progression of breast cancer. However, the function of miR‑28‑5p in breast cancer migration has yet to be determined. In the present study, Human MicroRNA Expression Database (HMED) analysis revealed that the expression level of miR‑28‑5p was s...

journal_title：International journal of molecular medicine

authors： Ma L,Zhang Y,Hu F

更新日期：2020-10-01 00:00:00

abstract：:In some patients with common variable immunodeficiency (CVID) and immunoglobulin (Ig) A deficiency (IgAD), tumor necrosis factor (TNF) family receptor transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) gene mutations have been reported. B cells from individuals with TACI mutations d...

journal_title：International journal of molecular medicine

authors： Jin R,Kaneko H,Suzuki H,Arai T,Teramoto T,Fukao T,Kondo N

更新日期：2008-02-01 00:00:00

abstract：:Regucalcin is a Ca2+-binding protein which plays a regulatory role in liver cell functions related to Ca2+. In this study we have cloned and characterized cDNA for regucalcin from human liver and human hepatoma cell line Hep G2 by screening and rapid amplification of cDNA ends (RACE). The nucleotide sequences of the c...

journal_title：International journal of molecular medicine

authors： Misawa H,Yamaguchi M

更新日期：2000-03-01 00:00:00

abstract：:Human-induced pluripotent (iPS) cells can be induced to differentiate into osteoblasts, but the process is inefficient and time-consuming. Previous studies indicated a close association between the expression of Runx2 and osteoblast differentiation, and established that the transcriptional activation of the Runx2 gene...

journal_title：International journal of molecular medicine

authors： Liu T,Hou L,Zhao Y,Huang Y

更新日期：2015-01-01 00:00:00

abstract：:Numerous studies have demonstrated the antioxidant effects of grape seed proanthocyanidin extract (GSPE). The generation of free radicals and the ensuing apoptosis may contribute to the pathogenesis of epilepsy; therefore, in the present study, we examined the effects of GSPE on cognitive impairment and neuronal damag...

journal_title：International journal of molecular medicine

authors： Zhen J,Qu Z,Fang H,Fu L,Wu Y,Wang H,Zang H,Wang W

更新日期：2014-08-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) occurs in patients with components of metabolic syndrome such as type 2 diabetes mellitus (T2DM). At present, the central pathophysiological problem in patients afflicted with NAFLD is insulin resistance. In this study, we aimed to determine the effects of a dipeptidyl peptida...

journal_title：International journal of molecular medicine

authors： Nakamura K,Fukunishi S,Yokohama K,Ohama H,Tsuchimoto Y,Asai A,Tsuda Y,Higuchi K

更新日期：2017-04-01 00:00:00

abstract：:Protein phosphorylation/dephosphorylation on tyrosine residues are regulated by tyrosine kinases/phosphatases. The tyrosine phosphatase SH-PTP2 (PTP1D, PTP2C) interacts physically through its SH2 domain with phosphorylated epidermal growth factor receptor (EGFR). In KB cells, an oral epidermoid carcinoma, high epiderm...

journal_title：International journal of molecular medicine

authors： Kamer AR,Hoghooghi SA,Liebow C

更新日期：1998-04-01 00:00:00

abstract：:The objective of this study was to detect interleukin-17 (IL-17), interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and forkhead/winged helix transcription factor p3 (Foxp3) protein and gene expression of the optic nerve and to further explore the role of T helper cell subsets such as Th1, Th2, Th17 and Treg in the p...

journal_title：International journal of molecular medicine

authors： Tian AY,Zhang RW,Shi XG,Yu HM

更新日期：2010-06-01 00:00:00

abstract：:Congenital heart disease (CHD), the most prevalent birth defect in humans worldwide, is still a leading non‑infectious cause of infant morbidity and mortality. Increasing evidence demonstrates that genetic risk factors play a key role in the pathogenesis of CHD, and more than 50 genes have been linked to various types...

journal_title：International journal of molecular medicine

authors： Pan Y,Geng R,Zhou N,Zheng GF,Zhao H,Wang J,Zhao CM,Qiu XB,Yang YQ,Liu XY

更新日期：2015-04-01 00:00:00

abstract：:Plasminogen activator inhibitor-1 (PAI-1), a member of the serpin super-family, forms a covalent complex with its target proteinases, such as tissue and urokinase plasminogen activators. Thus, PAI-1 controls the physiological and pathological proteolysis. An abnormal expression of PAI-1 has been observed in different ...

journal_title：International journal of molecular medicine

authors： Jankun J,Specht Z,Szkudlarek M,Greenfield R,Gaikwad B,Trifonov L,Vaugeois J,Aleem AM,Basrur V,Selman SH,Zavodszky MI,Skrzypczak-Jankun E

更新日期：2006-03-01 00:00:00

abstract：:Proteasome inhibitors, like MG132, can exert cell growth inhibitory and apoptotic effects in different tumor types. The apoptotic mechanism of these compounds involves the activation of the effector caspases. beta-catenin, also an oncogene, represents one of the substrates of these proteases, but the consequences of i...

journal_title：International journal of molecular medicine

authors： Cervello M,Giannitrapani L,La Rosa M,Notarbartolo M,Labbozzetta M,Poma P,Montalto G,D'Alessandro N

更新日期：2004-05-01 00:00:00

abstract：:The family of chromosomal high mobility group I/Y consists of proteins involved in gene regulation and chromatin organization. A common feature of these proteins is the presence of multiple copies of DNA binding domains (DBD), the so-called AT-hooks. Bi- or tridendate interaction of two or three DBDs with appropriatel...

journal_title：International journal of molecular medicine

authors： Wisniewski JR,Schwanbeck R

更新日期：2000-10-01 00:00:00

abstract：:Clinical observations and our high-density oligonucleotide microarray results demonstrated increased expression of proinflammatory chemokines after SARS-CoV infection. Here, we investigated the influence of SARS-CoV infection on CXCL8 (interleukin 8) and CXCL10 (interferon-gamma-inducible protein 10) in human intestin...

journal_title：International journal of molecular medicine

authors： Cinatl J Jr,Michaelis M,Morgenstern B,Doerr HW

更新日期：2005-02-01 00:00:00

abstract：:Hepatoblastoma is a rare pediatric liver tumor. While much progress has been made in the treatment of the disease, very little is known about the moleculer events underlying the pathogenesis of this disease. We sought to investigate a series of hepatoblastomas for alterations in gene expression patterns with emphasis ...

journal_title：International journal of molecular medicine

authors： Gray SG,Hartmann W,Eriksson T,Ekstrom C,Holm S,Kytola S,von Schweinitz D,Pietsch T,Larsson C,Kogner P,Sandstedt B,Ekstrom TJ

更新日期：2000-08-01 00:00:00

abstract：:Sindbis vectors have shown remarkable antitumor efficacy and tumor-targeting capacity in animal models and hold promise for cancer therapy. Different packaging systems are used to produce propagation-incompetent Sindbis vectors. However, the vectors produced using either DH-BB single helper RNA or split helper RNA can...

journal_title：International journal of molecular medicine

authors： Hyvärinen A,Yongabi F,Mäkinen K,Wahlfors J,Pellinen R

更新日期：2013-08-01 00:00:00