abstract：:Radiation therapy is an effective non-surgical means to achieve local control for various solid tumors including colorectal cancer (CRC), but metastasis and recurrences after conventional radiotherapy remains a major obstacle in clinical practice, and the knowledge concerning the changes of metastatic potential after ...

journal_title：American journal of cancer research

authors： Pan H,Song Y,Zhang H,Bai Y,Konishi T,Kobayashi A,Shao C,Pan Y

更新日期：2021-01-01 00:00:00

abstract：:Targeting phosphatidylinositol 3-kinase δ (PI3Kδ) is an important therapeutic strategy for indolent non-Hodgkin lymphomas (NHLs). However, we previously observed reactivation of phosphatidylinositol 3-kinase (PI3K) pathways in aggressive NHL cell lines following continuous exposure to PI3Kδ inhibitors (PI3Kδi), which ...

journal_title：American journal of cancer research

authors： Zuo W,Zhu Y,Liu Z,Xia Y,Xu Y,Peng C,Yu L,Wang N

更新日期：2021-01-01 00:00:00

abstract：:During the process of DNA replication, insertions or deletions of repeat sequences easily occur in microsatellites due to DNA polymerase slippage in instances of defective mismatch repair; this phenomenon is known as microsatellite instability. Based on genetic profiling, microsatellite instability gastric cancer is r...

journal_title：American journal of cancer research

authors： Yang G,Zheng RY,Tan Q,Dong CJ,Jin ZS

更新日期：2020-12-01 00:00:00

abstract：:The side effects of platinum-based chemotherapy are important factors limiting the survival of oral squamous cell carcinoma (OSCC) patients. Current research suggests that pyroptosis is involved in this process. However, how this mechanism can be used to reduce side effects has not yet been elucidated. In this study, ...

journal_title：American journal of cancer research

authors： Huang Z,Zhang Q,Wang Y,Chen R,Wang Y,Huang Z,Zhou G,Li H,Rui X,Jin T,Li S,Zhang Y,Huang Z

更新日期：2020-12-01 00:00:00

abstract：:Omega-3 polyunsaturated fatty acids (PUFAs), such as those found in fish oil, are thought to have anti-tumorigenic effects and may help to treat and prevent cancer, including ovarian cancer. Thus, we aimed to evaluate the potential of docosahexaenoic acid (DHA), an omega-3 PUFA, as a therapeutic agent in ovarian cance...

journal_title：American journal of cancer research

authors： West L,Yin Y,Pierce SR,Fang Z,Fan Y,Sun W,Tucker K,Staley A,Zhou C,Bae-Jump V

更新日期：2020-12-01 00:00:00

abstract：:Due to the refractory and partial sensitive treatments to malignant cancers, immunotherapy has increasingly become a hotspot in effective anti-tumor research. However, at present, existing animal models could not accurately describe the interaction between human tissue and tumor cells for preclinical trials. Furthermo...

journal_title：American journal of cancer research

authors： Yin L,Wang XJ,Chen DX,Liu XN,Wang XJ

更新日期：2020-12-01 00:00:00

abstract：:Metastasis is a crucial hallmark of cancer progression and remains the primary cause of patient deaths. Metastasis-associated proteases contribute to cancer progression by disrupting the extracellular matrix interaction to facilitate the spreading of cancer cells to other organs. ADAM9, a type of metalloprotease, has ...

journal_title：American journal of cancer research

authors： Lin YS,Hsieh CY,Kuo TT,Lin CC,Lin CY,Sher YP

更新日期：2020-11-01 00:00:00

abstract：:CD8+ T cells are crucial adaptive immune effectors and express receptors (T cell receptors, TCRs) that specifically recognize and eradicate tumor cells. The diversity of the TCR repertoire is generated by specialized genetic diversification mechanisms, which lead to an extremely variable TCR repertoire that is capable...

journal_title：American journal of cancer research

authors： Feng Z,Fang Q,Kuang X,Liu X,Chen Y,Ma D,Wang J

更新日期：2020-11-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the top three most deadly cancers despite using chemotherapy based on oxaliplatin or irinotecan combined with targeted therapy. Chiauranib has recently been identified to be a promising anticancer candidate with impressive efficacy and safety. However, the role and molecular mechanism...

journal_title：American journal of cancer research

authors： Yin H,Xie J,Jiang P,Jiang X,Duan D,Qi J,Luo Z,Ma C,Hong H

更新日期：2020-11-01 00:00:00

abstract：:Amino acid transporters mediate substrates across cellular membranes and their fine-tuned regulations are critical to cellular metabolism, growth, and death. As the functional component of system Xc-, which imports extracellular cystine with intracellular glutamate release at a ratio of 1:1, SLC7A11 has diverse functi...

journal_title：American journal of cancer research

authors： Lin W,Wang C,Liu G,Bi C,Wang X,Zhou Q,Jin H

更新日期：2020-10-01 00:00:00

abstract：:The trans-activation response DNA-binding protein of 43 kDa (TDP-43) is a nuclear protein that has been shown to be involved in the growth and metastasis of breast cancer, neuroblastoma, and melanoma. However, the effect of TDP-43 on hepatocellular carcinoma (HCC) metastasis remains unclear. Here, we demonstrated that...

journal_title：American journal of cancer research

authors： Guo F,Wang H,Jiang M,Yang Q,Xiang Q,Zhou H,Hu X,Hao K,Yang J,Cao H,Shen Z

更新日期：2020-10-01 00:00:00

abstract：:To determine easy-to-use predictors of overall survival (OS), locoregional recurrence (LRR), and distant metastasis (DM) in breast invasive ductal carcinoma (IDC) patients receiving neoadjuvant chemotherapy (NACT) and total mastectomy (TM), we used the pathologic response (PR) of primary breast diseases (T stages), no...

journal_title：American journal of cancer research

authors： Zhang J,Sun M,Chang E,Lu CY,Chen HM,Wu SY

更新日期：2020-10-01 00:00:00

abstract：:Human Schlafen-5 (SLFN5) is aberrantly involved in tumorigenesis in several types of cancer. However, its implications in breast cancer (BRCA) are unknown. Herein, we demonstrated that SLFN5 expression is negatively associated with the tumour growth of human BRCA using GEO database analysis and clinical sample immunos...

journal_title：American journal of cancer research

authors： Gu X,Wan G,Yang Y,Liu Y,Yang X,Zheng Y,Jiang L,Zhang P,Liu D,Zhao W,Huang G,Lu C

更新日期：2020-09-01 00:00:00

abstract：:Endoscopic submucosal dissection (ESD) is a minimally invasive alternative to esophagectomy for early esophageal squamous cell carcinoma (EESCC). The aim of this study was to compare the efficacy and safety of ESD and esophagectomy in EESCC with different depth of invasion. The data of EESCC patients who received ESD ...

journal_title：American journal of cancer research

authors： An W,Liu MY,Zhang J,Cui YP,Gao J,Wang LP,Chen Y,Yang LX,Chen HZ,Jin H,Liu F,Chen J,Li ZS,Wang LW,Shi XG,Sun C

更新日期：2020-09-01 00:00:00

abstract：:[This retracts the article on p. 314 in vol. 10, PMID: 32064170.]. ...

journal_title：American journal of cancer research

authors：

更新日期：2020-08-01 00:00:00

abstract：:Cancer stem cells play a major role in tumor initiation, progression, and tumor relapse of prostate cancer (PCa). Recent studies suggest that Translationally Controlled Tumor Protein (TCTP) is a critical survival factor of stem cells including cancer stem cells. Here, we aimed to determine whether the TCTP inhibitor s...

journal_title：American journal of cancer research

authors： Chinnapaka S,Bakthavachalam V,Munirathinam G

更新日期：2020-07-01 00:00:00

abstract：:To evaluate the effect of post-mastectomy radiation therapy (PMRT) stratified by clinical tumor (T) or nodal (N) staging and determine predictors of overall survival (OS), locoregional recurrence (LRR), distant metastasis, and disease-free survival (DFS) in patients with breast cancer who received neoadjuvant chemothe...

journal_title：American journal of cancer research

authors： Zhang JQ,Lu CY,Qin L,Chen HM,Wu SY

更新日期：2020-07-01 00:00:00

abstract：:N6-methyladenosine (m6A) is the most common internal modification of mRNAs in higher eukaryotic. This process is performed by methyltransferase. Methyltransferase-like 3 (METTL3) is the best known m6A methyltransferase that functions in the reversible epi-transcriptome modulation of m6A modification. Besides acting as...

journal_title：American journal of cancer research

authors： Liu S,Zhuo L,Wang J,Zhang Q,Li Q,Li G,Yan L,Jin T,Pan T,Sui X,Lv Q,Xie T

更新日期：2020-06-01 00:00:00

abstract：:In normal physiology, kallikrein-related peptidase 7 (KLK7), together with other members of the kallikrein-related peptidase family, is mainly involved in skin desquamation and keratinization processes. Moreover, expression of KLK7 was shown in various tumor types to be dysregulated and to correlate to patients' survi...

journal_title：American journal of cancer research

authors： Geng X,Babayeva L,Walch A,Aubele M,Groß E,Kiechle M,Bronger H,Dreyer T,Magdolen V,Dorn J

更新日期：2020-06-01 00:00:00

abstract：:[This corrects the article on p. 1252 in vol. 7, PMID: 28670489.]. ...

journal_title：American journal of cancer research

authors： Gupta N,Jagadish N,Surolia A,Suri A

更新日期：2020-06-01 00:00:00

abstract：:Psychological stress is a well-accepted risk factor in cancer initiation and progression. The explosive growth of psychoneuroimmunology research in the past decade has yielded an unprecedented wealth of information about the critical role of chronic stress in the immune dysfunction that influences tumor behaviors, whi...

journal_title：American journal of cancer research

authors： Zhang L,Pan J,Chen W,Jiang J,Huang J

更新日期：2020-05-01 00:00:00

abstract：:Napabucasin (NAPA) is thought to be a potent cancer stemness inhibitor in different types of cancer cell lines. While it has shown promising activity in early phase clinical trials, two recent phase III NAPA clinical trials failed to meet the primary endpoint of overall survival. The reason for the failure is not clea...

journal_title：American journal of cancer research

authors： Guo G,Gao Z,Tong M,Zhan D,Wang G,Wang Y,Qin J

更新日期：2020-05-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most prevalent malignancies in men. However, the molecular mechanism controlling the transformation of androgen-dependent PCa (ADPC) to castration-resistant PCa (CRPC) is largely unknown. Androgen receptor (AR) signaling has been reported to play a key role in this process; thus, se...

journal_title：American journal of cancer research

authors： Quan Y,Cui Y,Wahafu W,Liu Y,Ping H,Zhang X

更新日期：2020-05-01 00:00:00

abstract：:Circular RNAs (circRNAs) have been shown to regulate the development and progression of various cancers. However, the expression and function of circRNAs in papillary thyroid cancer (PTC) remain largely unknown. This study is aimed to investigate the potential roles of circEIF3I in PTC and elucidate the functional mec...

journal_title：American journal of cancer research

authors： Wang YF,Li MY,Tang YF,Jia M,Liu Z,Li HQ

更新日期：2020-04-01 00:00:00

abstract：:Recent studies have shown that IRF-1 plays a significant role in various tumour-induced chemoresistance, but its role and mechanism in gastric cancer-associated chemoresistance are not clear. Our study showed that IRF-1 expression could reverse gastric cancer-related chemoresistance. Dysregulated DNA repair is an impo...

journal_title：American journal of cancer research

authors： Tan L,Yuan J,Zhu W,Tao K,Wang G,Gao J

更新日期：2020-04-01 00:00:00

abstract：:Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors that arising from the adrenal medulla or extra-adrenal autonomic ganglia. Traditionally, PPGL was classified as benign or malignant based on the presence of distant metastasis at the time of initial surgery. However, according to WHO 2017 Classif...

journal_title：American journal of cancer research

authors： Wang Y,Li M,Deng H,Pang Y,Liu L,Guan X

更新日期：2020-03-01 00:00:00

abstract：:The N-terminal truncated carboxypeptidase E (CPEΔN) protein, an alternative splicing product of the carboxypeptidase E gene, has recently been recognized as an independent predictor for the recurrence and metastasis of lung adenocarcinoma. In this study, we showed that CPEΔN may accelerate lung cancer invasion via an ...

journal_title：American journal of cancer research

authors： Sun J,Meng D,Yu T,Li F,Zhang G,Tian X,Zhao N,Li G,Li L,Wang H,Liu Y,Meng Y,Ma Y,Wan Z,Bao J,Piao H

更新日期：2020-03-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is highly expressed in head and neck squamous cell carcinoma (HNSCC) and related to cancer progression. The resistance to anti-EGFR therapy remains a major clinical problem in HNSCC. In this study, we found that TOLL-like receptor 4 (TLR4) was highly expressed in 50% of EGFR ove...

journal_title：American journal of cancer research

authors： Ju H,Hu Z,Lu Y,Wu Y,Zhang L,Wei D,Guo W,Xia W,Liu S,Ren G,Hu J

更新日期：2020-02-01 00:00:00

abstract：:Angiopoietin-like 4 (ANGPLT4) regulates lipid metabolism by inhibiting lipoprotein lipase. Abnormal ANGTPL4 levels are associated with metabolic syndrome, atherosclerosis, inflammation, and cancer. We show here that ANGPTL4-deficient mice have abnormally large numbers of macrophages in the spleen, and that these macro...

journal_title：American journal of cancer research

authors： Ding S,Wu D,Lu Q,Qian L,Ding Y,Liu G,Jia X,Zhang Y,Xiao W,Gong W

更新日期：2020-02-01 00:00:00

abstract：:PD-1/PD-L1 immune checkpoint blockade therapy has become an effective method for the treatment of cancers in the clinic. It has great clinical advantages and therapeutic effects in the treatment of various cancers. However, a considerable number of cancer patients currently have relatively low response rates and drug ...

journal_title：American journal of cancer research

authors： Ju X,Zhang H,Zhou Z,Wang Q

更新日期：2020-01-01 00:00:00

abstract：:Lung adenocarcinoma (LUAD) is a common type of lung cancer characterized by a high incidence of local invasion and metastasis. Programmed cell death factor 4 (PDCD4) is a well-recognized tumor suppressor gene involved in LUAD, however its precise regulatory mechanism remains elusive. This is the first study to report ...

journal_title：American journal of cancer research

authors： Hu Y,Wei X,Lv Y,Xie X,Yang L,He J,Tao X,Ma Y,Su Y,Wu L,Fang W,Liu Z

更新日期：2020-01-01 00:00:00

abstract：:Radiosensitivity varies among patients with non-small cell lung cancer (NSCLC). In this work, we aimed to investigate microRNAs associated with this heterogeneity among individuals. We selected miR-1246 from the microRNAs that were revealed by microarray experiments to be differentially expressed between radioresistan...

journal_title：American journal of cancer research

authors： Fan L,Wang J,Cao Q,Ding X,Li B

更新日期：2020-01-01 00:00:00

abstract：:Pancreatic cancer (PC) is one of the most common gastrointestinal malignancies that are highly aggressive with a low 5-year survival rate. Accumulated evidence has indicated that decoy receptor 3 (DcR3) is involved in several pathologic processes and various cancers. However, the mechanisms underlying dysregulated DcR...

journal_title：American journal of cancer research

authors： Wei Y,Chen X,Yang J,Yao J,Yin N,Zhang Z,Li D,Zhu D,Zhou J

更新日期：2019-12-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine that serves many roles in inflammation and immunity; however, it is also involved in carcinogenesis. This is a review of the clinical and experimental data published on MIF and its role in various types of cancers such as glioblastomas, lung canc...

journal_title：American journal of cancer research

authors： Guda MR,Rashid MA,Asuthkar S,Jalasutram A,Caniglia JL,Tsung AJ,Velpula KK

更新日期：2019-12-01 00:00:00

abstract：:The mechanisms of how Never in Mitosis (NIMA) Related Kinase 2 (NEK2) coordinates altered signaling to malignant gastric cancer (GC) transformation remain unclear. Overexpression of NEK2 and KDM5B were observed in GC cell lines with high sensitivity to NEK2 inhibitors. Here we investigated the biological behaviors of ...

journal_title：American journal of cancer research

authors： Li Y,Chen L,Feng L,Zhu M,Shen Q,Fang Y,Liu X,Zhang X

更新日期：2019-11-01 00:00:00

abstract：:Colorectal cancer is one of the most commonly diagnosed malignancies among males and females worldwide. Although China is a country with a low incidence of colorectal cancer, with the improvement of China's economy and lifestyle changes, the incidence rate in China has generally increased in recent years, and the morb...

journal_title：American journal of cancer research

authors： Sun W,Ren S,Li R,Zhang Q,Song H

更新日期：2019-11-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is among the most common types of cancers that threat the public health worldwide. A growing body of evidence has demonstrated that m6A RNA methylation plays a critical role in tumorigenesis. However, the association between m6A RNA methylation regulators and prognosis of ...

journal_title：American journal of cancer research

authors： Zhao X,Cui L

更新日期：2019-10-01 00:00:00

abstract：:MYO10 is an actin-based motor protein and correlates with cancer metastasis. However, the regulation of MYO10 by tumor microenvironment is unknown. In the current study, we found that the expression of protease activated receptor 2 (PAR2) was highly correlated with that of MYO10 in colorectal carcinoma (CRC) specimens...

journal_title：American journal of cancer research

authors： Zhang X,Fang Q,Ma Y,Zou S,Liu Q,Wang H

更新日期：2019-09-01 00:00:00

abstract：:Cancer is a diverse class of diseases characterized by uncontrolled cell growth with the potential to invade and spread to other parts of the body, and continues to be one of the leading causes of death worldwide. Conventional cancer treatment modalities include antitumor drugs, surgical resection, locally targeted th...

journal_title：American journal of cancer research

authors： Kikuchi H,Yuan B,Hu X,Okazaki M

更新日期：2019-08-01 00:00:00

abstract：:Menin, a protein encoded by the MEN1 gene, suppresses cancers associated with multiple endocrine neoplasia type 1 (MEN1), but promotes the development of a subset of leukemia induced by mixed lineage leukemia (MLL)-derived fusion proteins (MLL-FPs). The crystal structure of menin indicates that it acts as a scaffold p...

journal_title：American journal of cancer research

authors： Wu Y,Doepner M,Hojnacki T,Feng Z,Katona BW,He X,Ma J,Cao Y,Busino L,Zhou F,Hua X

更新日期：2019-08-01 00:00:00