Abstract：
:Due to the refractory and partial sensitive treatments to malignant cancers, immunotherapy has increasingly become a hotspot in effective anti-tumor research. However, at present, existing animal models could not accurately describe the interaction between human tissue and tumor cells for preclinical trials. Furthermore, it is a tough obstacle to reconstitute the immune system and microenvironment in a mouse model identical to humans due to species differences. In the establishment of the humanized mouse model, the co-transplantation of human immunocytes with/without tissues and tumor cells is the key breakthrough to solve this problem. The compelling progress has been investigated in the preclinical drug test for diverse tumor types. This review mainly summarized the development of immunodeficient mice, and the construction and practicability of the humanized mouse model. Furthermore, the investigators also highlight the pros and cons, and recent progress in immunotherapy research for advanced utility of human cancer diseases.
journal_name
Am J Cancer Resjournal_title
American journal of cancer researchauthors
Yin L,Wang XJ,Chen DX,Liu XN,Wang XJsubject
Has Abstractpub_date
2020-12-01 00:00:00pages
4568-4584issue
12issn
2156-6976journal_volume
10pub_type
杂志文章,评审abstract：BACKGROUND:Chemotherapy resistance is a common problem faced by patients diagnosed with epithelial ovarian cancer (EOC). Currently there are no specific or sensitive clinical biomarkers that maybe implemented to identify chemotherapy resistance and give insight to prognosis. The aim of this study is to investigate the ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-01-15 00:00:00
abstract：:RNA binding motif, single stranded interacting protein 3 (RBMS3) has been reported as a tumor suppressor gene (TSG) in some squamous carcinoma. However, its expression levels and clinical significance in gastric cancer (GC) remains unclear. Secreted frizzled-related protein 1 (SFRP1) plays a role of tumor suppressor i...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-11-01 00:00:00
abstract：:Adrenergic receptors (ARs), especially β-ARs, are constitutively expressed in most mammalian cells and are associated with various malignancies including lung cancer. Epidemiologic studies have reported that activation of β-AR signalling promotes the development and progression of lung cancer and that pharmacological ...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2018-11-01 00:00:00
abstract：:Visfatin, a newly discovered adipocytokine, is a pro-inflammatory cytokine. This study aimed to evaluate the predictive value of visfatin on prognosis of patients with upper tract urothelial carcinoma. One-hundred and five patients (median age=64, range=24-84 years) were included in this study. Visfatin expression in ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-07-15 00:00:00
abstract：:Promoter methylation acts as an important alternative to genetic alterations for gene inactivation in gastric carcinogenesis. Although a number of gastric cancer-associated genes have been found to be methylated in gastric cancer, valuable methylation markers for early diagnosis and prognostic evaluation of this cance...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Targeting phosphatidylinositol 3-kinase δ (PI3Kδ) is an important therapeutic strategy for indolent non-Hodgkin lymphomas (NHLs). However, we previously observed reactivation of phosphatidylinositol 3-kinase (PI3K) pathways in aggressive NHL cell lines following continuous exposure to PI3Kδ inhibitors (PI3Kδi), which ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2021-01-01 00:00:00
abstract：:Osteosarcoma (OS) is the most common primary bone malignancies. Long noncoding RNAs (lncRNAs) are key regulatory RNAs which takes part in several biological processes. LncRNA neuroblastoma associated transcript 1 (NBAT1) is a newly identified functional lncRNA. NBAT1 functions as a tumor suppressor in some cancers. Ho...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-10-01 00:00:00
abstract：:Epidemiological evidence supports a protective effect of physical activity for breast cancer but pre-clinical studies are needed to help define the underlying mechanisms in an age-related manner. We utilized 18-month old BALB/c mice injected in the mammary fat pad with syngeneic 4T1 tumor cells as a model of invasive ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-07-16 00:00:00
abstract：:CS1 (also known as CD319, CRACC and SLAMF7) was identified as an NK cell receptor regulating immune functions. It is also expressed on B cells, T cells, Dendritic cells, NK-T cells, and monocytes. CS1 is overexpressed in multiple myeloma and makes it a target for immunotherapy. A humanized anti-CS1 antibody, Elotuzuma...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2017-08-01 00:00:00
abstract：:Clear cell renal cell carcinoma (ccRCC) is characterized by stabilization of hypoxia-inducible factor (HIF1), and mutations in von Hippel-Lindau (VHL) gene. Additionally, in about 40% of ccRCC cases the mutation in PBRM1 (POLYBROMO1) gene coding for a non-core subunit of SWI/SNF chromatin remodeling complex was found ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-11-01 00:00:00
abstract：:Over-activation of SUMOylation is correlated with poor prognosis in multiple myeloma (MM), with the mechanism unclear. Wnt signaling is one of the aberrantly regulated pathways related to cancer tumorigenesis and progression. Whether SUMOylation is involved in regulating the activity of Wnt/β-catenin pathway, however,...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-12-15 00:00:00
abstract：:Recent studies have shown that IRF-1 plays a significant role in various tumour-induced chemoresistance, but its role and mechanism in gastric cancer-associated chemoresistance are not clear. Our study showed that IRF-1 expression could reverse gastric cancer-related chemoresistance. Dysregulated DNA repair is an impo...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-04-01 00:00:00
abstract：:Endometrial cancer (EC) is the most common gynecological malignancy in women and is the leading cause of cancer-related deaths worldwide. Estrogenic stimulation significantly increases endometrial cell proliferation, and both insulin resistance and hyperinsulinemia are associated with the development of EC in women. I...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-01-15 00:00:00
abstract：:To investigate the chemotherapy-induced emotion regulation impairment and its neural correlates in breast cancer (BC) patients by event-related potentials (ERP), seventeen BC patients were investigated on emotion regulation paradigms while undergoing the recording of an event-related potential (ERP) both before and af...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-01-01 00:00:00
abstract：:Retinoic acid is an effective agent in the treatment of epithelial and hematological malignancies. The present study demonstrates that retinoic acid chalcone (RAC), an analogue of retinoic acid inhibits cell proliferation and induces apoptosis in HCT-15 and CT26.WT colon cancer cell lines. In HCT-15 cells the percenta...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-05-15 00:00:00
abstract：:Tumor-associated NADH oxidase (tNOX, ENOX2), which belongs to a family of growth-related NADH oxidases, was originally identified as a plasma membrane protein of rat hepatoma and is inhibited or downregulated by several anti-cancer drugs. The objective of this study was to evaluate the anti-tumor effects of tNOX used ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-04-01 00:00:00
abstract：:The trans-activation response DNA-binding protein of 43 kDa (TDP-43) is a nuclear protein that has been shown to be involved in the growth and metastasis of breast cancer, neuroblastoma, and melanoma. However, the effect of TDP-43 on hepatocellular carcinoma (HCC) metastasis remains unclear. Here, we demonstrated that...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-10-01 00:00:00
abstract：:Our previous study showed that 5-aza-2-deoxycytidine (5-aza-dC) could inhibit tumor growth by enhancing the susceptibility of ovarian clear cell carcinoma (OCCC) to paclitaxel through decreasing AKT/mTOR expressions. The objective of the study is to evaluate the antitumor efficacy of everolimus (RAD001) and 5-aza-2-de...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
abstract：:Urokinase plasminogen activator receptor (uPAR) is a GPI anchored cell surface protein that is closely associated with invasion, migration, and metastasis of cancer cells. Many functional extracellular proteins and transmembrane receptors interact with uPAR. However, few studies have examined the association of uPAR w...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-11-19 00:00:00
abstract：:PD-1/PD-L1 immune checkpoint blockade therapy has become an effective method for the treatment of cancers in the clinic. It has great clinical advantages and therapeutic effects in the treatment of various cancers. However, a considerable number of cancer patients currently have relatively low response rates and drug ...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2020-01-01 00:00:00
abstract：:We have previous found a positive correlation between post-therapy TCR repertoire normalization and remission of colorectal cancer (CRC) patients following fluorouracil, leucovorin, and irinotecan (FOLFIRI) plus bevacizumab or Rh-endostatin therapy. To further define the TCR repertoire diversity changes following trea...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-11-19 00:00:00
abstract：:Understanding mechanisms of cancer metastasis is crucial for reduction of cancer mortality. Acyl-CoA medium-chain synthetase 3 (ACSM3) is an acyl-CoA synthetase which takes part in the first step of fatty acid metabolism. However, the expression, clinical significance and biological function of ACSM3 remain unknown in...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-03-01 00:00:00
abstract：:We have studied the chemopreventive property of capsaicin, a major active component in chili pepper, and found that it exhibited apoptotic activity against various lines of cancer cells. Interestingly, accumulating data has revealed that, in addition to cytotoxicity, capsaicin also plays regulatory role on cell migrat...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-06-01 00:00:00
abstract：:Sphingosine 1-phosphate (S1P) rheostat is considered as a key signal that determines cell fate. This study aimed to report that hispidulin, a polyphenolic flavonoid, exerted anti-growth and anti-metastasis effects against renal cell carcinoma (RCC) by modulating the balance of ceramide-S1P. In vitro studies showed tha...
journal_title：American journal of cancer research
pub_type： 杂志文章,收录出版
doi：
更新日期：2017-07-01 00:00:00
abstract：:Angiopoietin-like 4 (ANGPLT4) regulates lipid metabolism by inhibiting lipoprotein lipase. Abnormal ANGTPL4 levels are associated with metabolic syndrome, atherosclerosis, inflammation, and cancer. We show here that ANGPTL4-deficient mice have abnormally large numbers of macrophages in the spleen, and that these macro...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-02-01 00:00:00
abstract：:[This corrects the article on p. 127 in vol. 6, PMID: 27186391.]. ...
journal_title：American journal of cancer research
pub_type： 已发布勘误
doi：
更新日期：2016-07-01 00:00:00
abstract：:MicroRNA-122 (miR-122) has been implicated in tumor development and progression in various types of cancers. However, the biological function and regulatory mechanisms of miR-122 in gastric cancer (GC) remain largely unknown. We aimed to determine the biological role and underlying mechanism of miR-122 in GC. Real tim...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-02-01 00:00:00
abstract：:Histone deacetylase (HDAC) is overexpressed in multiple cancers including pancreatic cancer (PC). However, the effects of histone deacetylase inhibitor (HDACi) on apoptosis and epithelial-mesenchymal transition (EMT) differ in various cancers. In this study, we aimed to investigate the anti-tumor effects of a novel mu...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-12-01 00:00:00
abstract：:Afatinib is the second generation of irreversible inhibitor of EGFR, HER2 and HER4, which has shown encouraging phase II and III clinical outcomes in the treatment of head and neck squamous cell carcinoma (HNSCC). However, the molecular mechanism of afatinib-induced apoptosis in HNSCC is poorly understood. In the pres...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-08-01 00:00:00
abstract：:The aim of this study was to evaluate the role of miR-146a in the drug resistance of chronic myelogenous leukemia (CML) cells (K562/ADM) and to investigate the reversal effect of physcion, a natural compound, on the multidrug-resistance in CML. Our results showed that miR-146a was significantly downregulated in drug-r...
journal_title：American journal of cancer research
pub_type： 杂志文章,收录出版
doi：
更新日期：2016-11-01 00:00:00
