Humanized mouse model: a review on preclinical applications for cancer immunotherapy.

Abstract:

:Due to the refractory and partial sensitive treatments to malignant cancers, immunotherapy has increasingly become a hotspot in effective anti-tumor research. However, at present, existing animal models could not accurately describe the interaction between human tissue and tumor cells for preclinical trials. Furthermore, it is a tough obstacle to reconstitute the immune system and microenvironment in a mouse model identical to humans due to species differences. In the establishment of the humanized mouse model, the co-transplantation of human immunocytes with/without tissues and tumor cells is the key breakthrough to solve this problem. The compelling progress has been investigated in the preclinical drug test for diverse tumor types. This review mainly summarized the development of immunodeficient mice, and the construction and practicability of the humanized mouse model. Furthermore, the investigators also highlight the pros and cons, and recent progress in immunotherapy research for advanced utility of human cancer diseases.

journal_name

Am J Cancer Res

authors

Yin L,Wang XJ,Chen DX,Liu XN,Wang XJ

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

4568-4584

issue

12

issn

2156-6976

journal_volume

10

pub_type

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