The American Journal of Cancer Research (AJCR) (ISSN 2156-6976), is an independent open access, online only journal to facilitate rapid dissemination of novel discoveries in basic science and treatment of cancer. It was founded by a group of scientists for cancer research and clinical academic oncologists from around the world, who are devoted to the promotion and advancement of our understanding of the cancer and its treatment. The scope of AJCR is intended to encompass that of multi-disciplinary researchers from any scientific discipline where the primary focus of the research is to increase and integrate knowledge about etiology and molecular mechanisms of carcinogenesis with the ultimate aim of advancing the cure and prevention of this increasingly devastating disease. To achieve these aims AJCR will publish review articles, original articles and new techniques in cancer research and therapy. It will also publish hypothesis, case reports and letter to the editor. Unlike most other open access online journals, AJCR will keep most of the traditional features of paper print that we are all familiar with, such as continuous volume, issue numbers, as well as continuous page numbers to retain our comfortable familiarity towards an academic journal. AJCR will be officially launched in January, 2011, and published as a quarterly journal. Publication frequencies can be increased to as bi-monthly or even monthly if more manuscripts are received. We are accepting manuscript submissions at this time. All manuscripts will be peer reviewed and published within two months if accepted. If you are interested in submitting a manuscript to AJCR for consideration of publication, please read the journal’s Guidelines for Author and e-mail the manuscript to the Editorial Office at manuscript@e-century.us. We are also inviting you to join the editorial board of AJCR. Please read the editorial board policy and then contact us together with your updated CV, 5-10 keywords of your research interest, the weblink of your professional webpage that is hosted in your affiliated university or institute if you are interested.