Abstract：
:We have previous found a positive correlation between post-therapy TCR repertoire normalization and remission of colorectal cancer (CRC) patients following fluorouracil, leucovorin, and irinotecan (FOLFIRI) plus bevacizumab or Rh-endostatin therapy. To further define the TCR repertoire diversity changes following treatment in CRC patients, and confirm its potential prognostic value, the present study extended the sample size of follow-up and used an alternative therapy regime to investigate changes of TCR repertoires following Erbitux plus FOLFIRI therapy. Inclusion and exclusion criteria have been established to screen out 26 patients to receive Erbitux plus FOLFIRI therapy. Efficacy and toxicity assessment have been made for them after 3 months' treatment as well as the TCR repertoire diversity has been determined. A CDR3 complex scoring system was used to quantify the diversity of TCR repertoire. The results showing that the diversity of CD4(+) T cells in PR group was significantly higher than that of SD and PD groups, and the difference was enlargement after treatment. The diversity of CD8(+) T cells in PR group has no difference before and after treatment, but significant decrease in SD and PD group after treatment. In conclusion, analysis the diversity of T cell repertoire has an important prognosis value for CRC patients.
journal_name
Am J Cancer Resjournal_title
American journal of cancer researchauthors
Luo W,He WT,Wen Q,Chen S,Wu J,Chen XP,Ma Lsubject
Has Abstractpub_date
2014-11-19 00:00:00pages
924-33issue
6issn
2156-6976journal_volume
4pub_type
杂志文章abstract：:Hepatitis B virus X protein (HBx) is involved in the pathogenesis of hepatocellular carcinoma (HCC). Overexpression of the transcripts from the P3 and P4 promoters of the insulin-like growth factor-II (IGF-II) gene is observed in HCC. The present study investigated the involvement of HBx in IGF-II overexpression and i...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-02-15 00:00:00
abstract：:Lung cancer stem cells (CSCs) have recently been isolated from lung cancer patient samples and have been reported to be responsible for tumor initiation, treatment resistance and tumor recurrence. We have previously shown that oncolytic Newcastle disease virus (NDV), strain FMW (NDV/FMW) induces apoptosis in drug-resi...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-11-15 00:00:00
abstract：:Targeting phosphatidylinositol 3-kinase δ (PI3Kδ) is an important therapeutic strategy for indolent non-Hodgkin lymphomas (NHLs). However, we previously observed reactivation of phosphatidylinositol 3-kinase (PI3K) pathways in aggressive NHL cell lines following continuous exposure to PI3Kδ inhibitors (PI3Kδi), which ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2021-01-01 00:00:00
abstract：:Epigenetic dysregulation is being increasingly recognized as a hallmark of cancer. Post-translational modifications of histones, in particular, are known to play important roles gene expression alterations in cancer development and progression. Given their key involvement in the various stages of carcinogenesis, histo...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Gamma-glutamylcyclotransferase (GGCT) was originally identified as a protein highly expressed in bladder cancer tissues by proteomic analysis, and its higher expression in a variety of cancers compared to normal tissues have been shown. Depletion of GGCT in various cancer cells results in antiproliferative effects bot...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-04-01 00:00:00
abstract：:Our previous study showed that 5-aza-2-deoxycytidine (5-aza-dC) could inhibit tumor growth by enhancing the susceptibility of ovarian clear cell carcinoma (OCCC) to paclitaxel through decreasing AKT/mTOR expressions. The objective of the study is to evaluate the antitumor efficacy of everolimus (RAD001) and 5-aza-2-de...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
abstract：:Radiation therapy is an effective non-surgical means to achieve local control for various solid tumors including colorectal cancer (CRC), but metastasis and recurrences after conventional radiotherapy remains a major obstacle in clinical practice, and the knowledge concerning the changes of metastatic potential after ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Chemotherapy resistance is a common problem faced by patients diagnosed with epithelial ovarian cancer (EOC). Currently there are no specific or sensitive clinical biomarkers that maybe implemented to identify chemotherapy resistance and give insight to prognosis. The aim of this study is to investigate the ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-01-15 00:00:00
abstract：:Histone modification and chromatin remodeling are important events in response to DNA damage, and Polycomb group (PcG) proteins, catalyzing H3K27 methylation, are involved. However, the biological function and mechanism of PcG in DNA damage are not fully understood. Additionally, downstream effectors in hepatocellular...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-09-01 00:00:00
abstract：:microRNAs (miRNAs) are frequently aberrantly expressed in osteosarcoma (OS) and are implicated in its development. Dysregulation of miR-758 has been reported in various human malignancies. However, whether miR-758 is involved in the oncogenesis and progression of OS remains unclear. In this study, reverse transcriptio...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-01-01 00:00:00
abstract：:Sphingosine 1-phosphate (S1P) rheostat is considered as a key signal that determines cell fate. This study aimed to report that hispidulin, a polyphenolic flavonoid, exerted anti-growth and anti-metastasis effects against renal cell carcinoma (RCC) by modulating the balance of ceramide-S1P. In vitro studies showed tha...
journal_title：American journal of cancer research
pub_type： 杂志文章,收录出版
doi：
更新日期：2017-07-01 00:00:00
abstract：:The aim of this study was to evaluate the role of miR-146a in the drug resistance of chronic myelogenous leukemia (CML) cells (K562/ADM) and to investigate the reversal effect of physcion, a natural compound, on the multidrug-resistance in CML. Our results showed that miR-146a was significantly downregulated in drug-r...
journal_title：American journal of cancer research
pub_type： 杂志文章,收录出版
doi：
更新日期：2016-11-01 00:00:00
abstract：:RNA binding motif, single stranded interacting protein 3 (RBMS3) has been reported as a tumor suppressor gene (TSG) in some squamous carcinoma. However, its expression levels and clinical significance in gastric cancer (GC) remains unclear. Secreted frizzled-related protein 1 (SFRP1) plays a role of tumor suppressor i...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-11-01 00:00:00
abstract：:Sexual dimorphism in the incidence of human esophageal cancer, including both esophageal adenocarcinoma and squamous cell carcinoma, shows male dominancy. However, the mechanisms that underlie sexual dimorphism of esophageal cancer have been understudied in vivo due to the lack of sex-dimorphic mouse models. Here, we ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-02-01 00:00:00
abstract：:Pancreatic cancer is the fourth most common cancer to cause death due to advanced stage at diagnosis and poor response to current treatment. Autophagy is the lysosome-mediated degradation pathway which plays a critical role in cellular defense, quality control, and energy metabolism. Targeting autophagy is now an exci...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Cervical cancer is often associated with hypoxia and many kinds of chemokines. But the relationship and role of hypoxia and Chemokine (C-C motif) ligand 17 (CCL17) in cervical cancer are still unknown. Here, we found that CCL17 was high expressed in cervical cancer. HeLa and SiHa cells could secrete CCL17 in a time-de...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-09-15 00:00:00
abstract：:Prostate cancer that has progressed to metastatic disease remains largely untreatable. Nearly 90% of patients with advanced prostate cancer develop skeletal metastases, resulting in a substantial reduction in the quality of life and a drastic worsening of patient prognosis. The mechanisms involved in prostate cancer c...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：:Many cancer management approaches including immunotherapies can not achieve desirable therapeutic efficacies if targeting tumors alone or could not effectively reach tumor cells. The concept of tumor microenvironment and its induced gene reprogramming have largely extended our current understandings on the determinant...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2019-05-01 00:00:00
abstract：:Early detection of cancer is the key to improving survival. Since most clinically used serum cancer biomarkers are either glycoproteins or glycan structures that can be recognized by specific monoclonal antibodies, developing glycan structure-based biomarkers from human serum/plasma glycoproteins through mass spectrom...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2016-11-01 00:00:00
abstract：:Over-activation of SUMOylation is correlated with poor prognosis in multiple myeloma (MM), with the mechanism unclear. Wnt signaling is one of the aberrantly regulated pathways related to cancer tumorigenesis and progression. Whether SUMOylation is involved in regulating the activity of Wnt/β-catenin pathway, however,...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-12-15 00:00:00
abstract：:Angiopoietin-like 4 (ANGPLT4) regulates lipid metabolism by inhibiting lipoprotein lipase. Abnormal ANGTPL4 levels are associated with metabolic syndrome, atherosclerosis, inflammation, and cancer. We show here that ANGPTL4-deficient mice have abnormally large numbers of macrophages in the spleen, and that these macro...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:The function of iASPP (inhibitory member of the ASPP family) in cervical adenocarcinoma remains unknown. The aim of this study was to explore the expression and clinical relevance of iASPP in early stage cervical adenocarcinoma. Methods The clinical data of 75 patients with FIGO stage IA2-IIA cervical adenoc...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-02-15 00:00:00
abstract：:Podoplanin is a small membrane glycoprotein with a large number of O-glycoside chains and therefore it belongs to mucin-type proteins. It can be found on the surface of many types of normal cells originating from various germ layers. It is present primarily on the endothelium of lymphatic vessels, type I pneumocytes a...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2016-01-15 00:00:00
abstract：:Urokinase plasminogen activator receptor (uPAR) is a GPI anchored cell surface protein that is closely associated with invasion, migration, and metastasis of cancer cells. Many functional extracellular proteins and transmembrane receptors interact with uPAR. However, few studies have examined the association of uPAR w...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-11-19 00:00:00
abstract：:Bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor A (VEGF-A), was used in combination with traditional chemotherapy as the first line treatment for metastatic colorectal cancer (mCRC), non-small cell lung cancer (NSCLC) and advanced ovarian cancer. However, it shows limited efficacy for h...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-08-01 00:00:00
abstract：:Evidence is accumulating that long non-coding RNAs (lncRNAs) exert crucial roles in the incidence and progression of tumors. HOXD cluster antisense RNA 1 (HOXD-AS1), a cancer-related lncRNA, has been frequently reported to be involved in tumorigenesis and dysregulated in multiple types of human cancers; however, littl...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
abstract：:Aberrant expression of the RON receptor tyrosine kinase, a member of the MET proto-oncogene family, contributes significantly to pancreatic cancer tumorigenesis and chemoresistance. Here we validate RON as a target for pancreatic cancer therapy using a novel anti-RON antibody Zt/g4-drug maytansinoid conjugates (Zt/g4-...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-05-01 00:00:00
abstract：:[This retracts the article on p. 2047 in vol. 5, PMID: 26269763.]. ...
journal_title：American journal of cancer research
pub_type： 撤回出版物
doi：
更新日期：2016-10-01 00:00:00
abstract：:Menin, a protein encoded by the MEN1 gene, suppresses cancers associated with multiple endocrine neoplasia type 1 (MEN1), but promotes the development of a subset of leukemia induced by mixed lineage leukemia (MLL)-derived fusion proteins (MLL-FPs). The crystal structure of menin indicates that it acts as a scaffold p...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-08-01 00:00:00
abstract：:A role for the minichromosome maintenance (MCM) proteins in cancer initiation and progression is slowly emerging. Functioning as a complex to ensure a single chromosomal replication per cell cycle, the six family members have been implicated in several neoplastic disease states, including breast cancer. Our study aim ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-12-15 00:00:00
