Abstract：
:A role for the minichromosome maintenance (MCM) proteins in cancer initiation and progression is slowly emerging. Functioning as a complex to ensure a single chromosomal replication per cell cycle, the six family members have been implicated in several neoplastic disease states, including breast cancer. Our study aim to investigate the prognostic significance of these proteins in breast cancer. We studied the expression of MCMs in various datasets and the associations of the expression with clinicopathological parameters. When considered alone, high level MCM4 overexpression was only weakly associated with shorter survival in the combined breast cancer patient cohort (n = 1441, Hazard Ratio = 1.31; 95% Confidence Interval = 1.11-1.55; p = 0.001). On the other hand, when we studied all six components of the MCM complex, we found that overexpression of all MCMs was strongly associated with shorter survival in the same cohort (n = 1441, Hazard Ratio = 1.75; 95% Confidence Interval = 1.31-2.34; p < 0.001), suggesting these MCM proteins may cooperate to promote breast cancer progression. Indeed, their expressions were significantly correlated with each other in these cohorts. In addition, we found that increasing number of overexpressed MCMs was associated with negative ER status as well as treatment response. Together, our findings are reproducible in seven independent breast cancer cohorts, with 1441 patients, and suggest that MCM profiling could potentially be used to predict response to treatment and prognosis in breast cancer patients.
journal_name
Am J Cancer Resjournal_title
American journal of cancer researchauthors
Kwok HF,Zhang SD,McCrudden CM,Yuen HF,Ting KP,Wen Q,Khoo US,Chan KYsubject
Has Abstractpub_date
2014-12-15 00:00:00pages
52-71issue
1issn
2156-6976journal_volume
5pub_type
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journal_title：American journal of cancer research
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更新日期：2018-11-01 00:00:00
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journal_title：American journal of cancer research
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journal_title：American journal of cancer research
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更新日期：2015-08-15 00:00:00
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pub_type： 杂志文章
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