Abstract：
:Despite remaining uncertainties and ongoing research it is possible to draw up a model for the role of (cancer) stem cells in both the initiation and progression of cancer towards metastasis. The cancer stem cell of origin and the cancer stem cell are, despite phenotypic similarities, genotypically different entities. Given the right circumstances provided by a combination of genomic changes and biochemical and physical interactions with its microenvironment, an epithelial cancer cell may undergo a phenotypic epithelial mesenchymal transition (EMT) towards a cancer stem cell. This transition conveys upon the cell crucial stem cell-like abilities which facilitate migration into the blood circulation as an individual circulating tumor cell, survive there, and subsequently seed into organ tissue where, once more in close interaction with its microenvironment, the process of clonal self renewal may start, leading to a metastatic tumor. Both in the primary tumor as well as in the metastatic tumor, partial differentiation of the cancer stem cell progeny leads to phenotypic heterogeneity. Throughout this complex process of cancer metastasis similarities with the way stem cells function during embryonic development, including the signaling pathways that mediate these functions, are evident. Deeper insight in the EMT process, plasticity of the resulting cancer stem cells, and the role of cancer stem cells in the metastatic process is expected to lead to novel anti-metastatic cancer therapies. Emerging human in vitro cancer models in the form of "organ-on-a-chip" may contribute valuable novel research tools to achieve this aim.
journal_name
Am J Cancer Resjournal_title
American journal of cancer researchauthors
van de Stolpe Asubject
Has Abstractpub_date
2013-01-01 00:00:00pages
107-16issue
1issn
2156-6976journal_volume
3pub_type
杂志文章abstract：:Colorectal cancer (CRC) is one of the top three most deadly cancers despite using chemotherapy based on oxaliplatin or irinotecan combined with targeted therapy. Chiauranib has recently been identified to be a promising anticancer candidate with impressive efficacy and safety. However, the role and molecular mechanism...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-11-01 00:00:00
abstract：:Chronic inflammation is a well-recognized pathogenic factor in tumor initiation and progression. Mice lacking the pro-oncogenic transcription factor STAT3 were shown to be protected from both colitis-associated and epidermal cancers induced by the AOM/DSS and DMBA/TPA protocols, respectively. However, these murine mod...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-09-06 00:00:00
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journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-02-01 00:00:00
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journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2020-06-01 00:00:00
abstract：:The high-mobility group A protein 2 (HMGA2) is a non-histone chromatin factor highly expressed in fetal tissue and malignant tumors but rarely detected within normal adult tissues. The clinical implications and biological functions of HMGA2 in endometrial carcinoma are largely unknown. Here we report that HMGA2 expres...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-01-15 00:00:00
abstract：:Overall survival of patients with hepatocellular carcinoma (HCC) remains poor, and the multidrug resistance of HCC cells contributes to the limited efficacy of anti-cancer drugs, and reduced time to recurrence. We systematically screened the expression of transporter genes in HCC samples and found that solute carrier ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-12-01 00:00:00
abstract：:Pyruvate kinase is a key enzyme in the glycolytic pathway that converts phosphoenolpyruvate to pyruvate, and the M2 isoform of pyruvate kinase (PKM2) is associated with cancer. PKM2 has been reported to function independently of its pyruvate kinase activity, which is crucial for cancer cell proliferation. Moreover, th...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-02-15 00:00:00
abstract：BACKGROUND AND OBJECTIVES:To investigate whether multidisciplinary team (MDT) intervention is associated with improved survival for patients with colorectal adenocarcinoma with liver or lung metastasis (CRA-LLM). METHODS:We enrolled 161 consecutive patients with histologically confirmed CRA-LLM at Taipei Medical Unive...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-09-01 00:00:00
abstract：:Rottlerin, a natural product isolated from Mallotus philippinensis, has been characterized as an effective chemoprevention agent in inhibiting tumor cell growth. Although multiple studies have revealed the role of rottlerin in tumorigenesis, the molecular mechanism of rottlerin-mediated anti-tumor activity has not bee...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Long non-coding RNAs (LncRNAs) have been reported as key regulators of tumor progression in recent decades. However, the potential molecular mechanisms of breast cancer are still unclear. With the development of sequencing technology, we discovered that LINC00673 is upregulated in tumor tissues. But the main...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-07-01 00:00:00
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journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
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journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-08-01 00:00:00
abstract：:PD-1/PD-L1 immune checkpoint blockade therapy has become an effective method for the treatment of cancers in the clinic. It has great clinical advantages and therapeutic effects in the treatment of various cancers. However, a considerable number of cancer patients currently have relatively low response rates and drug ...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2020-01-01 00:00:00
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journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-12-01 00:00:00
abstract：:Pancreatic cancer (PC) is one of the most common gastrointestinal malignancies that are highly aggressive with a low 5-year survival rate. Accumulated evidence has indicated that decoy receptor 3 (DcR3) is involved in several pathologic processes and various cancers. However, the mechanisms underlying dysregulated DcR...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-12-01 00:00:00
abstract：:Targeting phosphatidylinositol 3-kinase δ (PI3Kδ) is an important therapeutic strategy for indolent non-Hodgkin lymphomas (NHLs). However, we previously observed reactivation of phosphatidylinositol 3-kinase (PI3K) pathways in aggressive NHL cell lines following continuous exposure to PI3Kδ inhibitors (PI3Kδi), which ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2021-01-01 00:00:00
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journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-04-01 00:00:00
abstract：:[This retracts the article on p. 2047 in vol. 5, PMID: 26269763.]. ...
journal_title：American journal of cancer research
pub_type： 撤回出版物
doi：
更新日期：2016-10-01 00:00:00
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journal_title：American journal of cancer research
pub_type： 杂志文章,收录出版
doi：
更新日期：2017-07-01 00:00:00
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journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
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journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2020-03-01 00:00:00
abstract：:Colorectal cancer is one of the most commonly diagnosed malignancies among males and females worldwide. Although China is a country with a low incidence of colorectal cancer, with the improvement of China's economy and lifestyle changes, the incidence rate in China has generally increased in recent years, and the morb...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-11-01 00:00:00
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journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
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journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-11-01 00:00:00
abstract：:Early stages of melanoma can be successfully treated by surgical resection of the tumor, but there is still no effective treatment once it is progressed to metastatic phases. Although growing family of both melanoma metastasis promoting and metastasis suppressor genes have been reported be related to metastasis, the m...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-08-15 00:00:00
abstract：:Radiation remains an important component of cancer treatment. In addition to inducing tumor cell death through direct cytotoxic effects, radiation can also promote the regression of tumor via augment of immune response. Regulatory T cells (Tregs) are a unique subpopulation of CD4 positive cells, which are characterize...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2015-10-15 00:00:00
abstract：:OSCP1/NOR1 (organic solute carrier partner 1/oxidored-nitro domain-containing protein 1) is known as a transporter of various organic solutes into cells and also is reported to act as a tumor suppressor protein. Although overexpression of OSCP1 has been shown to play multiple roles in mammalian cell lines, its biologi...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-04-15 00:00:00
abstract：:Psychological stress is a well-accepted risk factor in cancer initiation and progression. The explosive growth of psychoneuroimmunology research in the past decade has yielded an unprecedented wealth of information about the critical role of chronic stress in the immune dysfunction that influences tumor behaviors, whi...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2020-05-01 00:00:00
abstract：:Exposure of tumor cells to ionizing radiation (IR) is widely known to induce a number of cellular changes. One way that IR can affect tumor cells is through the development of neoantigens which are new molecules that tumor cells express at the cell membrane following some insult or change to the cell. There have been ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：:Histone deacetylase (HDAC) is overexpressed in multiple cancers including pancreatic cancer (PC). However, the effects of histone deacetylase inhibitor (HDACi) on apoptosis and epithelial-mesenchymal transition (EMT) differ in various cancers. In this study, we aimed to investigate the anti-tumor effects of a novel mu...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-12-01 00:00:00
