Pleiotropic role of macrophage migration inhibitory factor in cancer.

Abstract:

:Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine that serves many roles in inflammation and immunity; however, it is also involved in carcinogenesis. This is a review of the clinical and experimental data published on MIF and its role in various types of cancers such as glioblastomas, lung cancer, breast cancer, gastric cancer, melanoma, bladder cancer, and head and neck cancers. The goal of this review is to show MIFs role in various types of cancers. Data show that MIF is overexpressed in these malignancies in humans, and contributes to the deregulation of the cell cycle, angiogenesis, and metastasis. Clinical studies show that MIF overexpression in these types of tumors significantly decreases survival rate, and increases tumor aggression. There are multiple anti-MIF molecules that are currently being explored and investigations should be continued.

journal_name

Am J Cancer Res

authors

Guda MR,Rashid MA,Asuthkar S,Jalasutram A,Caniglia JL,Tsung AJ,Velpula KK

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

2760-2773

issue

12

issn

2156-6976

journal_volume

9

pub_type

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