Abstract：
:The transcription factor MEF2 promotes survival in various cell types and a number of studies indicate that abnormal regulation of MEF2 is linked to oncogenicity in several carcinomas. We have found that MEF2D, a member of the MEF2 family, is upregulated in Ovarian Cancer (OC). Immunohistochemistry analysis of tumor sections of 402 OC patients revealed that MEF2D is significantly elevated at the protein level. We have also found that the expression level of MEF2D is associated with cisplatin-resistance and poor prognosis by a retrospective analysis. Furthermore, Downregulation of MEF2D by siRNA reduces proliferation and invasiveness of OC cells SKOV3 and OVCAR3, induces apoptosis in vitro, and abolishes OVCAR3 tumorigenicity in xenograft model. Mechanistic study via ChIP analysis identified two of MEF2D-targeted genes, HPSE and IKBKE, which are associated with tumor invasion and chemotherapy-resistance, in accord with MEF2D expression in OC. Remarkably, knock-down of MEF2D invariably lead to the downregulation of IKBKE and reversed cisplatin (DDP)-resistance in cisplatin-resistant cells SKOV3-DDP. Our results suggest that MEF2D promotes malignant biological behaviors and cisplatin-resistance in OC and establish MEF2D as a new therapeutic target in OC treatment.
journal_name
Am J Cancer Resjournal_title
American journal of cancer researchauthors
Li X,Zhang Y,Chai X,Zhou S,Zhang H,He J,Zhou R,Cai L,Chen L,Tao Gsubject
Has Abstractpub_date
2019-05-01 00:00:00pages
887-905issue
5issn
2156-6976journal_volume
9pub_type
杂志文章abstract：UNLABELLED:Background Malignant peritoneal mesothelioma (MPM) is a rare neoplasm of the peritoneal membrane that is causally related to asbestos exposure. Survival after treatment is poor. Current therapy involving hyperthermic intraperitoneal chemotherapy has improved survival in selective patients. In the past, sever...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2013-06-20 00:00:00
abstract：:Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors that arising from the adrenal medulla or extra-adrenal autonomic ganglia. Traditionally, PPGL was classified as benign or malignant based on the presence of distant metastasis at the time of initial surgery. However, according to WHO 2017 Classif...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:The function of iASPP (inhibitory member of the ASPP family) in cervical adenocarcinoma remains unknown. The aim of this study was to explore the expression and clinical relevance of iASPP in early stage cervical adenocarcinoma. Methods The clinical data of 75 patients with FIGO stage IA2-IIA cervical adenoc...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-02-15 00:00:00
abstract：:In addition to direct oncolysis, oncolytic viruses trigger immunogenic cell death (ICD) and primes antitumor immunity. We have previously shown that oncolytic Newcastle disease virus (NDV), strain FMW (NDV/FMW), induces apoptosis and/or autophagy in cancer cells. In this study, we investigated whether oncolytic NDV ca...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-08-01 00:00:00
abstract：:Recent studies have shown that IRF-1 plays a significant role in various tumour-induced chemoresistance, but its role and mechanism in gastric cancer-associated chemoresistance are not clear. Our study showed that IRF-1 expression could reverse gastric cancer-related chemoresistance. Dysregulated DNA repair is an impo...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-04-01 00:00:00
abstract：:Histone modification and chromatin remodeling are important events in response to DNA damage, and Polycomb group (PcG) proteins, catalyzing H3K27 methylation, are involved. However, the biological function and mechanism of PcG in DNA damage are not fully understood. Additionally, downstream effectors in hepatocellular...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-09-01 00:00:00
abstract：:Head and neck squamous cell carcinoma (HNSCC) is among the most common types of cancers that threat the public health worldwide. A growing body of evidence has demonstrated that m6A RNA methylation plays a critical role in tumorigenesis. However, the association between m6A RNA methylation regulators and prognosis of ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-10-01 00:00:00
abstract：:Osteosarcoma is a rare malignant bone tumor in adolescents, with high degree of malignancy, and highly incidence of recurrence and metastasis. Our study aimed to explore the role of miR-101 in osteosarcoma cells by targeting ROCK1. In the present study, reverse transcription-quantitative polymerase chain reaction data...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
abstract：:Understanding mechanisms of cancer metastasis is crucial for reduction of cancer mortality. Acyl-CoA medium-chain synthetase 3 (ACSM3) is an acyl-CoA synthetase which takes part in the first step of fatty acid metabolism. However, the expression, clinical significance and biological function of ACSM3 remain unknown in...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-03-01 00:00:00
abstract：:Thyroid cancer is the most common endocrine malignancy. Although an association between inflammation and thyroid cancer has long been recognized, a cause-effect relationship at the molecular level has yet to be elucidated. We explored how inflammation could contribute to thyroid carcinogenesis in ThrbPV/PVPten+/- mice...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-07-01 00:00:00
abstract：:Epidemiological evidence supports a protective effect of physical activity for breast cancer but pre-clinical studies are needed to help define the underlying mechanisms in an age-related manner. We utilized 18-month old BALB/c mice injected in the mammary fat pad with syngeneic 4T1 tumor cells as a model of invasive ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-07-16 00:00:00
abstract：:Amino acid transporters mediate substrates across cellular membranes and their fine-tuned regulations are critical to cellular metabolism, growth, and death. As the functional component of system Xc-, which imports extracellular cystine with intracellular glutamate release at a ratio of 1:1, SLC7A11 has diverse functi...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2020-10-01 00:00:00
abstract：:CS1 (also known as CD319, CRACC and SLAMF7) was identified as an NK cell receptor regulating immune functions. It is also expressed on B cells, T cells, Dendritic cells, NK-T cells, and monocytes. CS1 is overexpressed in multiple myeloma and makes it a target for immunotherapy. A humanized anti-CS1 antibody, Elotuzuma...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2017-08-01 00:00:00
abstract：:Pyruvate kinase is a key enzyme in the glycolytic pathway that converts phosphoenolpyruvate to pyruvate, and the M2 isoform of pyruvate kinase (PKM2) is associated with cancer. PKM2 has been reported to function independently of its pyruvate kinase activity, which is crucial for cancer cell proliferation. Moreover, th...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-02-15 00:00:00
abstract：:SOX2 is an embryonic stem cell marker that in prostate cancer has been associated not only with tumorigenesis but also metastasis. Furthermore hypoxia in primary tumors has been linked to poor prognosis and outcomes in this disease. The goal of the present study was to investigate the impact of hypoxia on SOX2 express...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-05-01 00:00:00
abstract：:Glioblastoma (GBM) is the most frequent brain cancer with poor prognosis and few therapies and urgently requires effective treatments. Na+/K+-ATPase is considered as a target for GBM therapy and development of anticancer drugs. Cardiac glycosides bind the Na+/K+-ATPase α subunit to inhibit enzymatic activity and are p...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-06-01 00:00:00
abstract：:[This retracts the article on p. 314 in vol. 10, PMID: 32064170.]. ...
journal_title：American journal of cancer research
pub_type： 杂志文章,撤回出版物
doi：
更新日期：2020-08-01 00:00:00
abstract：:CBX7 is a polycomb protein that participates in the formation of polycomb repressive complex 1. Apart from few exceptions, CBX7 expression is lost in human malignant neoplasias and a clear correlation between its downregulated expression and a cancer aggressiveness and poor prognosis has been observed. These findings ...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2015-04-15 00:00:00
abstract：:The de novo fatty acid synthesis catalyzed by key lipogenic enzymes, including fatty acid synthase (FASN) has emerged as one of the novel targets of anti-cancer approaches. The present study explored the possible inhibitory efficacy of [6]-gingerol on de novo fatty acid synthesis associated with mitochondrial-dependen...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-03-15 00:00:00
abstract：:Evidence suggests that over-expression of TWIST, an epithelial-mesenchymal transition inducer, might have a correlation with cancer progression and chemoresistance. However, its roles in radioresistance of cancer have rarely been reported. High TWIST expression was detected in nasopharyngeal carcinoma (NPC) and associ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-03-15 00:00:00
abstract：:Lung adenocarcinoma (LUAD) is a common type of lung cancer characterized by a high incidence of local invasion and metastasis. Programmed cell death factor 4 (PDCD4) is a well-recognized tumor suppressor gene involved in LUAD, however its precise regulatory mechanism remains elusive. This is the first study to report ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Gliomas are the most common aggressive brain tumors and have many complex pathological types. Previous reports have discovered that genetic mutations are associated with the risk of glioma. However, it is unclear whether uniform genetic mutations exist difference between glioma and its two pathological types...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-06-15 00:00:00
abstract：:Caveolin-1 is a ubiquitously expressed integral membrane protein and essential for the formation of so-called Caveolae, small invaginations of the plasma membrane. Caveolae are involved in major physiological functions of the mammalian cell, including endocytosis and transcytosis processes, signal transduction and cho...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：:MicroRNA-365 (miR-365) has been reported to play an important role in tumorigenesis in many types of cancers; however, the role of miR-365 in the carcinogenesis of ovarian cancer remains unknown. In this study, we focused on the roles and underlying mechanisms of miR-365 in ovarian cancer. Here, we found that miR-365 ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Long non-coding RNAs (LncRNAs) have been reported as key regulators of tumor progression in recent decades. However, the potential molecular mechanisms of breast cancer are still unclear. With the development of sequencing technology, we discovered that LINC00673 is upregulated in tumor tissues. But the main...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-07-01 00:00:00
abstract：:Clear cell renal cell carcinoma (ccRCC) is characterized by stabilization of hypoxia-inducible factor (HIF1), and mutations in von Hippel-Lindau (VHL) gene. Additionally, in about 40% of ccRCC cases the mutation in PBRM1 (POLYBROMO1) gene coding for a non-core subunit of SWI/SNF chromatin remodeling complex was found ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:malignant peritoneal mesothelioma (MPM) is a rare peritoneal mesothelial neoplasm. Ki67 and BCL2 are established prognostic markers in several cancers. High Ki67 expression indicates tumour progression, whilst similar expression of BCL2 retards tumour replication. Traditionally, prognosis in MPM is gauged wi...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2013-08-14 00:00:00
abstract：:Promoter methylation acts as an important alternative to genetic alterations for gene inactivation in gastric carcinogenesis. Although a number of gastric cancer-associated genes have been found to be methylated in gastric cancer, valuable methylation markers for early diagnosis and prognostic evaluation of this cance...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Epidermal growth factor receptor (EGFR) is highly expressed in head and neck squamous cell carcinoma (HNSCC) and related to cancer progression. The resistance to anti-EGFR therapy remains a major clinical problem in HNSCC. In this study, we found that TOLL-like receptor 4 (TLR4) was highly expressed in 50% of EGFR ove...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-02-01 00:00:00
abstract：:Yes-associated protein (YAP), the central mediator of Hippo pathway, not only regulates a diversity of cellular processes during development but also plays a pivotal role in tumorigenesis. YAP is overexpressed in many types of human cancers with its expression level being associated with patient outcomes. Thus, inhibi...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-12-15 00:00:00
