Abstract：
:CBX7 is a polycomb protein that participates in the formation of polycomb repressive complex 1. Apart from few exceptions, CBX7 expression is lost in human malignant neoplasias and a clear correlation between its downregulated expression and a cancer aggressiveness and poor prognosis has been observed. These findings indicate a critical role of CBX7 in cancer progression. Consistently, CBX7 is able to differentially regulate crucial genes involved in cancer progression and in epithelial-mesenchymal transition, as osteopontin and E-cadherin. Recent evidences indicate a role of CBX7 also in the modulation of response to therapy. In conclusion, CBX7 represents an important prognostic factor, whose loss of expression in general indicates a bad prognosis and a progression towards a fully malignant phenotype.
journal_name
Am J Cancer Resjournal_title
American journal of cancer researchauthors
Pallante P,Forzati F,Federico A,Arra C,Fusco Asubject
Has Abstractpub_date
2015-04-15 00:00:00pages
1594-601issue
5issn
2156-6976journal_volume
5pub_type
杂志文章,评审abstract：:Dehydrocostus lactone (DHE), a natural sesquiterpene lactone, has been used for treatment of various diseases with its anti-inflammatory activity. Recently, it has caused extensive interest in researchers due to it has anti-cancer abilities in some types of carcinomas. However, the anti-cancer effect and mechanism of ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-06-01 00:00:00
abstract：:MicroRNA-122 (miR-122) has been implicated in tumor development and progression in various types of cancers. However, the biological function and regulatory mechanisms of miR-122 in gastric cancer (GC) remain largely unknown. We aimed to determine the biological role and underlying mechanism of miR-122 in GC. Real tim...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-02-01 00:00:00
abstract：:Our previous study showed that 5-aza-2-deoxycytidine (5-aza-dC) could inhibit tumor growth by enhancing the susceptibility of ovarian clear cell carcinoma (OCCC) to paclitaxel through decreasing AKT/mTOR expressions. The objective of the study is to evaluate the antitumor efficacy of everolimus (RAD001) and 5-aza-2-de...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
abstract：:N6-methyladenosine (m6A) is the most common internal modification of mRNAs in higher eukaryotic. This process is performed by methyltransferase. Methyltransferase-like 3 (METTL3) is the best known m6A methyltransferase that functions in the reversible epi-transcriptome modulation of m6A modification. Besides acting as...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:The function of iASPP (inhibitory member of the ASPP family) in cervical adenocarcinoma remains unknown. The aim of this study was to explore the expression and clinical relevance of iASPP in early stage cervical adenocarcinoma. Methods The clinical data of 75 patients with FIGO stage IA2-IIA cervical adenoc...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-02-15 00:00:00
abstract：:Platinum agents induce cancer cell death through BCL2-dependent intrinsic apoptotic pathway and are commonly used as anti-tumor drug. In this study, we evaluated whether single nucleotide polymorphism (SNPs) of BCL2 can affect the overall survival (OS) and progression-free survival (PFS) in non-small-cell lung cancer ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-10-01 00:00:00
abstract：:Evidence suggests that over-expression of TWIST, an epithelial-mesenchymal transition inducer, might have a correlation with cancer progression and chemoresistance. However, its roles in radioresistance of cancer have rarely been reported. High TWIST expression was detected in nasopharyngeal carcinoma (NPC) and associ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-03-15 00:00:00
abstract：:Cancer stem cells (CSCs) that closely correlated with tumor growth, metastasis, provide a plausible explanation for chemoresistance and cancer relapse. CSCs are usually isolated and enriched from carcinoma cells, which is inconvenient, low-efficient, and even unreliable. Here, we converted mouse induced pluripotent st...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-08-01 00:00:00
abstract：:Retinoic acid is an effective agent in the treatment of epithelial and hematological malignancies. The present study demonstrates that retinoic acid chalcone (RAC), an analogue of retinoic acid inhibits cell proliferation and induces apoptosis in HCT-15 and CT26.WT colon cancer cell lines. In HCT-15 cells the percenta...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-05-15 00:00:00
abstract：:The development of new cancer therapeutics would benefit from incorporating efficient tumor models that mimic human disease. We have developed a subcutaneous bladder tumor regeneration system that recapitulates primary human bladder tumor architecture by recombining benign human fetal bladder stromal cells with SW780 ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Due to the refractory and partial sensitive treatments to malignant cancers, immunotherapy has increasingly become a hotspot in effective anti-tumor research. However, at present, existing animal models could not accurately describe the interaction between human tissue and tumor cells for preclinical trials. Furthermo...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:TrkC, a member of neurotrophin receptor family, functions not only as an oncogene, but also act as a tumor suppressor via a manner of dependence receptor in human malignant tumors. Little is known on the action of TrkC for the clinical prognosis and the progression of breast cancer according to the availabil...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-11-19 00:00:00
abstract：:Adrenergic receptors (ARs), especially β-ARs, are constitutively expressed in most mammalian cells and are associated with various malignancies including lung cancer. Epidemiologic studies have reported that activation of β-AR signalling promotes the development and progression of lung cancer and that pharmacological ...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2018-11-01 00:00:00
abstract：:The de novo fatty acid synthesis catalyzed by key lipogenic enzymes, including fatty acid synthase (FASN) has emerged as one of the novel targets of anti-cancer approaches. The present study explored the possible inhibitory efficacy of [6]-gingerol on de novo fatty acid synthesis associated with mitochondrial-dependen...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-03-15 00:00:00
abstract：:Mismatch repair (MMR) plays a key role in maintaining genomic stability. Mismatch repair deficiency (MMR-D) causes a molecular feature of microsatellite instability (MSI) and contributes to the development of human cancers and genetic diseases with cancer predisposition such as Lynch syndrome. Recent studies have show...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Long non-coding RNAs (LncRNAs) have been reported as key regulators of tumor progression in recent decades. However, the potential molecular mechanisms of breast cancer are still unclear. With the development of sequencing technology, we discovered that LINC00673 is upregulated in tumor tissues. But the main...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-07-01 00:00:00
abstract：:Despite recent advances in surgical technique and treatment strategies for esophageal cancer (EC), to effectively manage the advanced (metastatic or disseminated) and recurrent EC still remain a great challenge. The aim of this study was to determine the feasibility of using intra-esophagus radiofrequency hyperthermia...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-09-01 00:00:00
abstract：:Pyruvate kinase is a key enzyme in the glycolytic pathway that converts phosphoenolpyruvate to pyruvate, and the M2 isoform of pyruvate kinase (PKM2) is associated with cancer. PKM2 has been reported to function independently of its pyruvate kinase activity, which is crucial for cancer cell proliferation. Moreover, th...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-02-15 00:00:00
abstract：BACKGROUND:Tumor-associated macrophages (TAMs) are a key component of the inflammatory microenvironment. Their role in prostate cancer development and progression remains unclear. We examined whether the amount of TAMs in prostate cancer is: 1) higher than prostatic intraepithelial neoplasia (PIN) and benign tissue 2) ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2013-11-01 00:00:00
abstract：:SOX2 is an embryonic stem cell marker that in prostate cancer has been associated not only with tumorigenesis but also metastasis. Furthermore hypoxia in primary tumors has been linked to poor prognosis and outcomes in this disease. The goal of the present study was to investigate the impact of hypoxia on SOX2 express...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-05-01 00:00:00
abstract：:MYO10 is an actin-based motor protein and correlates with cancer metastasis. However, the regulation of MYO10 by tumor microenvironment is unknown. In the current study, we found that the expression of protease activated receptor 2 (PAR2) was highly correlated with that of MYO10 in colorectal carcinoma (CRC) specimens...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-09-01 00:00:00
abstract：:The aim of this study was to evaluate the role of miR-146a in the drug resistance of chronic myelogenous leukemia (CML) cells (K562/ADM) and to investigate the reversal effect of physcion, a natural compound, on the multidrug-resistance in CML. Our results showed that miR-146a was significantly downregulated in drug-r...
journal_title：American journal of cancer research
pub_type： 杂志文章,收录出版
doi：
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVES:The composition and structure of site-specific microbiota have been investigated as potential biomarkers for a variety of chronic inflammatory diseases and cancers. While many studies have focused on the changes in the airway microbiota using respiratory specimens from patients with various respiratory disea...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-09-01 00:00:00
abstract：:Increasing evidences have shown that long noncoding RNAs (lncRNAs) play critical regulatory roles in cancer biology. However, the contributions of lncRNAs to colorectal cancer remain largely unknown. Here, we identify a lncRNA AFAP1-AS1 that facilitates colorectal cancer, where it is upregulated. AFAP1-AS1 expression ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-05-01 00:00:00
abstract：:Sphingosine 1-phosphate (S1P) rheostat is considered as a key signal that determines cell fate. This study aimed to report that hispidulin, a polyphenolic flavonoid, exerted anti-growth and anti-metastasis effects against renal cell carcinoma (RCC) by modulating the balance of ceramide-S1P. In vitro studies showed tha...
journal_title：American journal of cancer research
pub_type： 杂志文章,收录出版
doi：
更新日期：2017-07-01 00:00:00
abstract：:This study aims to elucidate the effects of microRNA-27a (miR-27a) on the proliferation and invasion of gastric cancer (GC) cells by targeting SFRP1 via Wnt/β-catenin signaling pathway. GC and normal adjacent tissues were collected from 273 GC patients. Human gastric cancer cell line (MGC803) and normal human gastric ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-03-01 00:00:00
abstract：:Gamma-glutamylcyclotransferase (GGCT) was originally identified as a protein highly expressed in bladder cancer tissues by proteomic analysis, and its higher expression in a variety of cancers compared to normal tissues have been shown. Depletion of GGCT in various cancer cells results in antiproliferative effects bot...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-04-01 00:00:00
abstract：:We have previous found a positive correlation between post-therapy TCR repertoire normalization and remission of colorectal cancer (CRC) patients following fluorouracil, leucovorin, and irinotecan (FOLFIRI) plus bevacizumab or Rh-endostatin therapy. To further define the TCR repertoire diversity changes following trea...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-11-19 00:00:00
abstract：:miRNA, which involves in pathogenesis of thyroid cancer via different targets, has been found aberrantly expressed in thyroid cancer. Modes of actions of miR-26a in papillary thyroid carcinoma (PTC), however, have not been fully understood to this date. In vitro results obtained from this research confirmed miR-26a wa...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-06-01 00:00:00
abstract：:Endoscopic submucosal dissection (ESD) is a minimally invasive alternative to esophagectomy for early esophageal squamous cell carcinoma (EESCC). The aim of this study was to compare the efficacy and safety of ESD and esophagectomy in EESCC with different depth of invasion. The data of EESCC patients who received ESD ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-09-01 00:00:00
