Abstract：
:Increasing evidences have shown that long noncoding RNAs (lncRNAs) play critical regulatory roles in cancer biology. However, the contributions of lncRNAs to colorectal cancer remain largely unknown. Here, we identify a lncRNA AFAP1-AS1 that facilitates colorectal cancer, where it is upregulated. AFAP1-AS1 expression was associated with colorectal cancer patient survival. AFAP1-AS1 knockdown inhibited cell proliferation, cell cycle, and tumorigenesis in an subcutaneous mouse xenograft model system. Further data demonstrated that AFAP1-AS1 was associated with enhancer of zeste homolog 2 (EZH2) and that this association was required for the repression of EZH2 target genes. Our findings indicate that AFAP1-AS1 is an oncogenic lncRNA that promotes tumor progression and may be a novel prognostic factor in colorectal cancer. Targeting AFAP1-AS1 might be a potential therapeutic strategy for colorectal cancer treatment.
journal_name
Am J Cancer Resjournal_title
American journal of cancer researchauthors
Tang J,Zhong G,Wu J,Chen H,Jia Ysubject
Has Abstractpub_date
2018-05-01 00:00:00pages
892-902issue
5issn
2156-6976journal_volume
8pub_type
杂志文章abstract：:Due to the refractory and partial sensitive treatments to malignant cancers, immunotherapy has increasingly become a hotspot in effective anti-tumor research. However, at present, existing animal models could not accurately describe the interaction between human tissue and tumor cells for preclinical trials. Furthermo...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2020-12-01 00:00:00
abstract：:Urokinase plasminogen activator receptor (uPAR) is a GPI anchored cell surface protein that is closely associated with invasion, migration, and metastasis of cancer cells. Many functional extracellular proteins and transmembrane receptors interact with uPAR. However, few studies have examined the association of uPAR w...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-11-19 00:00:00
abstract：:The high-mobility group A protein 2 (HMGA2) is a non-histone chromatin factor highly expressed in fetal tissue and malignant tumors but rarely detected within normal adult tissues. The clinical implications and biological functions of HMGA2 in endometrial carcinoma are largely unknown. Here we report that HMGA2 expres...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-01-15 00:00:00
abstract：:Hepatitis B virus X protein (HBx) is involved in the pathogenesis of hepatocellular carcinoma (HCC). Overexpression of the transcripts from the P3 and P4 promoters of the insulin-like growth factor-II (IGF-II) gene is observed in HCC. The present study investigated the involvement of HBx in IGF-II overexpression and i...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-02-15 00:00:00
abstract：:In addition to direct oncolysis, oncolytic viruses trigger immunogenic cell death (ICD) and primes antitumor immunity. We have previously shown that oncolytic Newcastle disease virus (NDV), strain FMW (NDV/FMW), induces apoptosis and/or autophagy in cancer cells. In this study, we investigated whether oncolytic NDV ca...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-08-01 00:00:00
abstract：:Castration-resistant prostate cancer (CRPC) ultimately occurs after a period of treatment with androgen deprivation therapy. Furthermore, CRPC patients can only derive limited survival benefits from traditional cytotoxic drugs. HSP90, which is a molecular chaperone, plays a vital role in client protein processing and ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-09-15 00:00:00
abstract：:2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) is a dietary mutagenic carcinogen that has been shown not only to induce the formation of DNA adducts, but is capable of inducing tumors in the colon, mammary, and prostate glands. The normal development and maturation of the prostate gland, as well as early progre...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-12-15 00:00:00
abstract：:Understanding mechanisms of cancer metastasis is crucial for reduction of cancer mortality. Acyl-CoA medium-chain synthetase 3 (ACSM3) is an acyl-CoA synthetase which takes part in the first step of fatty acid metabolism. However, the expression, clinical significance and biological function of ACSM3 remain unknown in...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-03-01 00:00:00
abstract：:Promoter methylation acts as an important alternative to genetic alterations for gene inactivation in gastric carcinogenesis. Although a number of gastric cancer-associated genes have been found to be methylated in gastric cancer, valuable methylation markers for early diagnosis and prognostic evaluation of this cance...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:CBX7 is a polycomb protein that participates in the formation of polycomb repressive complex 1. Apart from few exceptions, CBX7 expression is lost in human malignant neoplasias and a clear correlation between its downregulated expression and a cancer aggressiveness and poor prognosis has been observed. These findings ...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2015-04-15 00:00:00
abstract：:Cancer stem cells play a major role in tumor initiation, progression, and tumor relapse of prostate cancer (PCa). Recent studies suggest that Translationally Controlled Tumor Protein (TCTP) is a critical survival factor of stem cells including cancer stem cells. Here, we aimed to determine whether the TCTP inhibitor s...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-07-01 00:00:00
abstract：:Epidemiological evidence supports a protective effect of physical activity for breast cancer but pre-clinical studies are needed to help define the underlying mechanisms in an age-related manner. We utilized 18-month old BALB/c mice injected in the mammary fat pad with syngeneic 4T1 tumor cells as a model of invasive ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-07-16 00:00:00
abstract：:This study aims to elucidate the effects of microRNA-27a (miR-27a) on the proliferation and invasion of gastric cancer (GC) cells by targeting SFRP1 via Wnt/β-catenin signaling pathway. GC and normal adjacent tissues were collected from 273 GC patients. Human gastric cancer cell line (MGC803) and normal human gastric ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-03-01 00:00:00
abstract：:Osteosarcoma (OS) is the most common primary bone tumor in adolescents. Dysregulation of long noncoding RNAs (lncRNAs) is associated with the cancer progression, of which cancer susceptibility candidate 11 (CASC11) has been indicated as an oncogene in several human cancers. However, the underlying mechanisms by which ...
journal_title：American journal of cancer research
pub_type： 杂志文章,收录出版
doi：
更新日期：2019-02-01 00:00:00
abstract：:Oral squamous cell carcinoma (OSCC) remains to be a challenging public health problem worldwide. However, the underlying molecular mechanism regulating the carcinogenesis of OSCC is poorly known. Gene expression profiles of GSE13601, GSE30784, GSE37991 and The Cancer Genome Atlas (TCGA) head and neck cancer were downl...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-03-01 00:00:00
abstract：:Endometrial cancer (EC) is the most common gynecological malignancy in women and is the leading cause of cancer-related deaths worldwide. Estrogenic stimulation significantly increases endometrial cell proliferation, and both insulin resistance and hyperinsulinemia are associated with the development of EC in women. I...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-01-15 00:00:00
abstract：:A role for the minichromosome maintenance (MCM) proteins in cancer initiation and progression is slowly emerging. Functioning as a complex to ensure a single chromosomal replication per cell cycle, the six family members have been implicated in several neoplastic disease states, including breast cancer. Our study aim ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-12-15 00:00:00
abstract：BACKGROUND:The function of iASPP (inhibitory member of the ASPP family) in cervical adenocarcinoma remains unknown. The aim of this study was to explore the expression and clinical relevance of iASPP in early stage cervical adenocarcinoma. Methods The clinical data of 75 patients with FIGO stage IA2-IIA cervical adenoc...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-02-15 00:00:00
abstract：:Gastric carcinoma is one of the most lethal malignancies of cancers and its prognosis remains dismal due to the paucity of effective therapeutic targets. Herein, we showed that HRAS is markedly up-regulated in gastric carcinoma. Prognostic analysis indicated that HRAS expression might be a prognostic indicator for the...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-09-01 00:00:00
abstract：:EGFR-mutant lung cancer is an important molecular subtype in Asia considering that almost 40%-50% of patients with lung adenocarcinoma in Asian carry the active EGFR mutaiton. People have greatly anticipated the efficacy of PD-1/PD-L1 monoclonal antibody in lung cancer treatment but anti-PD-1/PD-L1 treatment failed to...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-10-01 00:00:00
abstract：:We have previous found a positive correlation between post-therapy TCR repertoire normalization and remission of colorectal cancer (CRC) patients following fluorouracil, leucovorin, and irinotecan (FOLFIRI) plus bevacizumab or Rh-endostatin therapy. To further define the TCR repertoire diversity changes following trea...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-11-19 00:00:00
abstract：:Evidence is accumulating that long non-coding RNAs (lncRNAs) exert crucial roles in the incidence and progression of tumors. HOXD cluster antisense RNA 1 (HOXD-AS1), a cancer-related lncRNA, has been frequently reported to be involved in tumorigenesis and dysregulated in multiple types of human cancers; however, littl...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
abstract：:Amplification of human Her2 and its aberrant signaling in 20-30% of early breast cancer patients is responsible for highly aggressive tumors with poor outcome. Grb7 is reported to be co-amplified with Her2. We report a concurrent high expression of mRNA (from FFPE tumor samples; mRNA correlation, Pearson r(2)= 0.806),...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2013-04-03 00:00:00
abstract：:Pancreatic cancer (PC) is one of the most common gastrointestinal malignancies that are highly aggressive with a low 5-year survival rate. Accumulated evidence has indicated that decoy receptor 3 (DcR3) is involved in several pathologic processes and various cancers. However, the mechanisms underlying dysregulated DcR...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-12-01 00:00:00
abstract：:Many cancer management approaches including immunotherapies can not achieve desirable therapeutic efficacies if targeting tumors alone or could not effectively reach tumor cells. The concept of tumor microenvironment and its induced gene reprogramming have largely extended our current understandings on the determinant...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2019-05-01 00:00:00
abstract：:Visfatin, a newly discovered adipocytokine, is a pro-inflammatory cytokine. This study aimed to evaluate the predictive value of visfatin on prognosis of patients with upper tract urothelial carcinoma. One-hundred and five patients (median age=64, range=24-84 years) were included in this study. Visfatin expression in ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-07-15 00:00:00
abstract：:Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors that arising from the adrenal medulla or extra-adrenal autonomic ganglia. Traditionally, PPGL was classified as benign or malignant based on the presence of distant metastasis at the time of initial surgery. However, according to WHO 2017 Classif...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2020-03-01 00:00:00
abstract：:miRNA, which involves in pathogenesis of thyroid cancer via different targets, has been found aberrantly expressed in thyroid cancer. Modes of actions of miR-26a in papillary thyroid carcinoma (PTC), however, have not been fully understood to this date. In vitro results obtained from this research confirmed miR-26a wa...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-06-01 00:00:00
abstract：:Human transcriptional positive cofactor 4 (PC4) is a novel marker for diagnosis and treatment of advanced human cancers metastasis. In human lung adenocarcinoma, tumor lymphangiogenesis, an important early event, can promotes lymphatic metastasis, while it has been reported that VEGF-C/VEGF-D/VEGFR-3 axis plays an imp...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-05-15 00:00:00
abstract：:RABEX-5 has been studied in various solid tumors, but its role in non-small-cell lung cancer (NSCLC) remains unknown. This study is aimed to investigate the expression, the potential relevance to clinicopathological characters and prognostic significance of RABEX-5 in patients with NSCLC. A total of 120 NSCLC patients...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-08-15 00:00:00
