Abstract：
:Adrenergic receptors (ARs), especially β-ARs, are constitutively expressed in most mammalian cells and are associated with various malignancies including lung cancer. Epidemiologic studies have reported that activation of β-AR signalling promotes the development and progression of lung cancer and that pharmacological interference by β-AR blockers could partially reverse lung cancer progression. In this review, we mainly focus on the role of β-ARs in lung cancer and then reveal the possible application of AR blockers in anti-tumour therapy for lung cancer.
journal_name
Am J Cancer Resjournal_title
American journal of cancer researchauthors
Huang Q,Tan Q,Mao K,Yang G,Ma G,Luo P,Wang S,Mei P,Wu F,Xu J,Guo M,Lv Z,Fan J,Zhang S,Wang X,Jin Ysubject
Has Abstractpub_date
2018-11-01 00:00:00pages
2227-2237issue
11issn
2156-6976journal_volume
8pub_type
杂志文章,评审abstract：:Trifluridine/tipiracil (FTD/TPI or TFTD, also known as TAS-102) with a molar ratio of 1:0.5, is a novel combination of FTD, an antineoplastic thymidine analog, and TPI, an inhibitor of thymidine phosphorylase. It has been approved as a treatment for unresectable advanced or recurrent colorectal cancer. Irinotecan (CPT...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-12-01 00:00:00
abstract：:A role for the minichromosome maintenance (MCM) proteins in cancer initiation and progression is slowly emerging. Functioning as a complex to ensure a single chromosomal replication per cell cycle, the six family members have been implicated in several neoplastic disease states, including breast cancer. Our study aim ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-12-15 00:00:00
abstract：BACKGROUND:Long non-coding RNAs (LncRNAs) have been reported as key regulators of tumor progression in recent decades. However, the potential molecular mechanisms of breast cancer are still unclear. With the development of sequencing technology, we discovered that LINC00673 is upregulated in tumor tissues. But the main...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-07-01 00:00:00
abstract：:Sexual dimorphism in the incidence of human esophageal cancer, including both esophageal adenocarcinoma and squamous cell carcinoma, shows male dominancy. However, the mechanisms that underlie sexual dimorphism of esophageal cancer have been understudied in vivo due to the lack of sex-dimorphic mouse models. Here, we ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-02-01 00:00:00
abstract：:OSCP1/NOR1 (organic solute carrier partner 1/oxidored-nitro domain-containing protein 1) is known as a transporter of various organic solutes into cells and also is reported to act as a tumor suppressor protein. Although overexpression of OSCP1 has been shown to play multiple roles in mammalian cell lines, its biologi...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-04-15 00:00:00
abstract：:Identification of pancreatic cysts with malignant potential is important to prevent pancreatic cancer development. Integrity of cell free DNA (cfDNA) has been described as tumor biomarker, but its potential for pancreatic cancer is unclear. While normal apoptotic cells release uniformly truncated DNA, malignant tissue...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-08-01 00:00:00
abstract：:Osteosarcoma is a rare malignant bone tumor in adolescents, with high degree of malignancy, and highly incidence of recurrence and metastasis. Our study aimed to explore the role of miR-101 in osteosarcoma cells by targeting ROCK1. In the present study, reverse transcription-quantitative polymerase chain reaction data...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
abstract：:We have previous found a positive correlation between post-therapy TCR repertoire normalization and remission of colorectal cancer (CRC) patients following fluorouracil, leucovorin, and irinotecan (FOLFIRI) plus bevacizumab or Rh-endostatin therapy. To further define the TCR repertoire diversity changes following trea...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-11-19 00:00:00
abstract：:Glioma is one of the most common, rapidly progressive and fatal brain tumors, and accumulating evidence shows that microRNAs (miRNAs) play important roles in the development of cancers, including glioma. Therapeutic applications of miRNAs in Ras-driven glioma have been proposed; however, their specific functions and m...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-04-01 00:00:00
abstract：:Histone modification and chromatin remodeling are important events in response to DNA damage, and Polycomb group (PcG) proteins, catalyzing H3K27 methylation, are involved. However, the biological function and mechanism of PcG in DNA damage are not fully understood. Additionally, downstream effectors in hepatocellular...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-09-01 00:00:00
abstract：:Pancreatic cancer is the fourth most common cancer to cause death due to advanced stage at diagnosis and poor response to current treatment. Autophagy is the lysosome-mediated degradation pathway which plays a critical role in cellular defense, quality control, and energy metabolism. Targeting autophagy is now an exci...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Evidence suggests that over-expression of TWIST, an epithelial-mesenchymal transition inducer, might have a correlation with cancer progression and chemoresistance. However, its roles in radioresistance of cancer have rarely been reported. High TWIST expression was detected in nasopharyngeal carcinoma (NPC) and associ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-03-15 00:00:00
abstract：:Lung cancer stem cells (CSCs) have recently been isolated from lung cancer patient samples and have been reported to be responsible for tumor initiation, treatment resistance and tumor recurrence. We have previously shown that oncolytic Newcastle disease virus (NDV), strain FMW (NDV/FMW) induces apoptosis in drug-resi...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-11-15 00:00:00
abstract：:Pancreatic cancer (PC) is one of the most common gastrointestinal malignancies that are highly aggressive with a low 5-year survival rate. Accumulated evidence has indicated that decoy receptor 3 (DcR3) is involved in several pathologic processes and various cancers. However, the mechanisms underlying dysregulated DcR...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:TrkC, a member of neurotrophin receptor family, functions not only as an oncogene, but also act as a tumor suppressor via a manner of dependence receptor in human malignant tumors. Little is known on the action of TrkC for the clinical prognosis and the progression of breast cancer according to the availabil...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-11-19 00:00:00
abstract：:We aimed to identify interesting deleted chromosomal regions for bladder cancer diagnosis and carcinogenesis, and to evaluate the association between loss of heterozygosity (LOH) and clinico-pathological parameters. Microsatellite analysis was performed on urine sediment and tumor tissue from 43 consecutive patients w...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：:Lung adenocarcinoma (LUAD) is a common type of lung cancer characterized by a high incidence of local invasion and metastasis. Programmed cell death factor 4 (PDCD4) is a well-recognized tumor suppressor gene involved in LUAD, however its precise regulatory mechanism remains elusive. This is the first study to report ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:Human transcriptional positive cofactor 4 (PC4) is a novel marker for diagnosis and treatment of advanced human cancers metastasis. In human lung adenocarcinoma, tumor lymphangiogenesis, an important early event, can promotes lymphatic metastasis, while it has been reported that VEGF-C/VEGF-D/VEGFR-3 axis plays an imp...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-05-15 00:00:00
abstract：:[This retracts the article on p. 314 in vol. 10, PMID: 32064170.]. ...
journal_title：American journal of cancer research
pub_type： 杂志文章,撤回出版物
doi：
更新日期：2020-08-01 00:00:00
abstract：:Regulation of the Hippo pathway via phosphorylation of Yorkie (Yki), the Drosophila homolog of human Yes-associated protein 1, is conserved from Drosophila to humans. Overexpression of a non-phosphorylatable form of Yki induces severe overgrowth in adult fly eyes. Here, we show that yki mRNA associates with microsomal...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-03-01 00:00:00
abstract：:Gamma-glutamylcyclotransferase (GGCT) was originally identified as a protein highly expressed in bladder cancer tissues by proteomic analysis, and its higher expression in a variety of cancers compared to normal tissues have been shown. Depletion of GGCT in various cancer cells results in antiproliferative effects bot...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-04-01 00:00:00
abstract：:Glioblastoma (GBM) is the most frequent brain cancer with poor prognosis and few therapies and urgently requires effective treatments. Na+/K+-ATPase is considered as a target for GBM therapy and development of anticancer drugs. Cardiac glycosides bind the Na+/K+-ATPase α subunit to inhibit enzymatic activity and are p...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-06-01 00:00:00
abstract：:Circular RNAs (circRNAs) are a series of special closed circular RNA molecules with stability and conservatism. In recent years, advances in high-throughput RNA sequencing technology have led to explosive discovery of circRNAs in different types of species and cells. Moreover, circRNAs can accomplish a remarkable mult...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2018-07-01 00:00:00
abstract：:Prostate cancer (PCa) is one of the most prevalent malignancies in men. However, the molecular mechanism controlling the transformation of androgen-dependent PCa (ADPC) to castration-resistant PCa (CRPC) is largely unknown. Androgen receptor (AR) signaling has been reported to play a key role in this process; thus, se...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-05-01 00:00:00
abstract：:Prostate cancer that has progressed to metastatic disease remains largely untreatable. Nearly 90% of patients with advanced prostate cancer develop skeletal metastases, resulting in a substantial reduction in the quality of life and a drastic worsening of patient prognosis. The mechanisms involved in prostate cancer c...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：:Oral squamous cell carcinoma (OSCC) remains to be a challenging public health problem worldwide. However, the underlying molecular mechanism regulating the carcinogenesis of OSCC is poorly known. Gene expression profiles of GSE13601, GSE30784, GSE37991 and The Cancer Genome Atlas (TCGA) head and neck cancer were downl...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-03-01 00:00:00
abstract：:Early stages of melanoma can be successfully treated by surgical resection of the tumor, but there is still no effective treatment once it is progressed to metastatic phases. Although growing family of both melanoma metastasis promoting and metastasis suppressor genes have been reported be related to metastasis, the m...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-08-15 00:00:00
abstract：:Pyruvate kinase is a key enzyme in the glycolytic pathway that converts phosphoenolpyruvate to pyruvate, and the M2 isoform of pyruvate kinase (PKM2) is associated with cancer. PKM2 has been reported to function independently of its pyruvate kinase activity, which is crucial for cancer cell proliferation. Moreover, th...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-02-15 00:00:00
abstract：:The trans-activation response DNA-binding protein of 43 kDa (TDP-43) is a nuclear protein that has been shown to be involved in the growth and metastasis of breast cancer, neuroblastoma, and melanoma. However, the effect of TDP-43 on hepatocellular carcinoma (HCC) metastasis remains unclear. Here, we demonstrated that...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-10-01 00:00:00
abstract：:Paediatric glioneuronal tumour with neuropil-like islands (GTNI) is a rare neoplasm of neuronal differentiation and diffusely infiltrating astroglial and oligodendrocyte-like components. The 2007 World Health Organization classification of central nervous system tumours considered it as a pattern variation of anaplast...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-12-01 00:00:00
