Abstract：
:CD8+ T cells are crucial adaptive immune effectors and express receptors (T cell receptors, TCRs) that specifically recognize and eradicate tumor cells. The diversity of the TCR repertoire is generated by specialized genetic diversification mechanisms, which lead to an extremely variable TCR repertoire that is capable of recognizing a wide range of antigens. However, the variations in CD8+ TCR diversity and their clinical implications in acute myeloid leukemia (AML) patients remain unknown. CD8+ T cells were enriched from 10 healthy donors and 31 AML patients at diagnosis and after chemotherapy, and TCRβ deep sequencing was performed to analyze CD8+ T cell clonal expansion and TCR repertoire diversity. Diminished TCR repertoire diversity and increased T cell clone expansion were noted in the bone marrow of AML patients. In relapsed patients, T cells were found to be more clonally expanded after chemotherapy than at new diagnosis. Moreover, significantly more expanded TCRβ clonotypes were noted in CD8+ PD-1+ T cells than in CD8+ PD-1- T cells regardless of the time of examination. Our systematic T cell repertoire analysis may help better characterize CD8+ T cells before and after chemotherapy in AML, which may provide insights into therapeutic strategies for hematological malignancies.
journal_name
Am J Cancer Resjournal_title
American journal of cancer researchauthors
Feng Z,Fang Q,Kuang X,Liu X,Chen Y,Ma D,Wang Jsubject
Has Abstractpub_date
2020-11-01 00:00:00pages
3973-3989issue
11issn
2156-6976journal_volume
10pub_type
杂志文章abstract：:Clear cell renal cell carcinoma (ccRCC) is characterized by stabilization of hypoxia-inducible factor (HIF1), and mutations in von Hippel-Lindau (VHL) gene. Additionally, in about 40% of ccRCC cases the mutation in PBRM1 (POLYBROMO1) gene coding for a non-core subunit of SWI/SNF chromatin remodeling complex was found ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-11-01 00:00:00
abstract：:Angiopoietin-like 4 (ANGPLT4) regulates lipid metabolism by inhibiting lipoprotein lipase. Abnormal ANGTPL4 levels are associated with metabolic syndrome, atherosclerosis, inflammation, and cancer. We show here that ANGPTL4-deficient mice have abnormally large numbers of macrophages in the spleen, and that these macro...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-02-01 00:00:00
abstract：:SOX2 is an embryonic stem cell marker that in prostate cancer has been associated not only with tumorigenesis but also metastasis. Furthermore hypoxia in primary tumors has been linked to poor prognosis and outcomes in this disease. The goal of the present study was to investigate the impact of hypoxia on SOX2 express...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-05-01 00:00:00
abstract：:Factors within the tissue of breast cancer (BC) may shift the polarization of CD4+ T cells towards Th2 direction. This tendency can promote tumor development and be enhanced by the use of tamoxifen during the treatment. Thus, the patients with low levels of tumor-induced Th2 polarization prior to tamoxifen treatment m...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-01-15 00:00:00
abstract：:Human transcriptional positive cofactor 4 (PC4) is a novel marker for diagnosis and treatment of advanced human cancers metastasis. In human lung adenocarcinoma, tumor lymphangiogenesis, an important early event, can promotes lymphatic metastasis, while it has been reported that VEGF-C/VEGF-D/VEGFR-3 axis plays an imp...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-05-15 00:00:00
abstract：:In this study, we investigated the role of cancer-associated fibroblasts (CAFs) in hepatocellular carcinoma (HCC) progression. We showed that CAFs secrete high levels of IL-6, which promoted stem cell-like properties in HCC cells by activating Notch signaling through STAT3 Tyr705 phosphorylation. These effects were ab...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2018-02-01 00:00:00
abstract：:The link between high-risk human Papillomavirus (HR-HPV) and other sexually transmitted diseases (STDs) in the risk of developing cervical cancer still unclear. Thus, in this report we investigated the rates of co-infections between HPV and other important non-HPV STDs in different cervical findings using a multiplex ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-06-01 00:00:00
abstract：:microRNAs (miRNAs) are frequently aberrantly expressed in osteosarcoma (OS) and are implicated in its development. Dysregulation of miR-758 has been reported in various human malignancies. However, whether miR-758 is involved in the oncogenesis and progression of OS remains unclear. In this study, reverse transcriptio...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-01-01 00:00:00
abstract：:Menin, a protein encoded by the MEN1 gene, suppresses cancers associated with multiple endocrine neoplasia type 1 (MEN1), but promotes the development of a subset of leukemia induced by mixed lineage leukemia (MLL)-derived fusion proteins (MLL-FPs). The crystal structure of menin indicates that it acts as a scaffold p...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-08-01 00:00:00
abstract：:Metastasis is a crucial hallmark of cancer progression and remains the primary cause of patient deaths. Metastasis-associated proteases contribute to cancer progression by disrupting the extracellular matrix interaction to facilitate the spreading of cancer cells to other organs. ADAM9, a type of metalloprotease, has ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2020-11-01 00:00:00
abstract：:Yes-associated protein (YAP), the central mediator of Hippo pathway, not only regulates a diversity of cellular processes during development but also plays a pivotal role in tumorigenesis. YAP is overexpressed in many types of human cancers with its expression level being associated with patient outcomes. Thus, inhibi...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-12-15 00:00:00
abstract：:Glioblastoma multiforme (GBM) is the deadliest and most common form of malignant primary brain tumor in humans. However, until now, little is known about the glioma genesis and progression at the molecular level. Here we report that overexpression of sine oculis homeobox homolog 1 (Six1), a developmental transcription...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-04-15 00:00:00
abstract：:Tumor-associated NADH oxidase (tNOX, ENOX2), which belongs to a family of growth-related NADH oxidases, was originally identified as a plasma membrane protein of rat hepatoma and is inhibited or downregulated by several anti-cancer drugs. The objective of this study was to evaluate the anti-tumor effects of tNOX used ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-04-01 00:00:00
abstract：:Pancreatic cancer (PC) is one of the most malignant tumors. Rho GTPases can affect several types of human cancers, including PC. In this study, we investigated the role of Ras homolog family member T1 (RHOT1), a new member of Rho GTPases in PC. IHC results showed that RHOT1 was expressed significantly higher in PC tis...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2015-03-15 00:00:00
abstract：:[This retracts the article on p. 2865 in vol. 5, PMID: 26609492.]. ...
journal_title：American journal of cancer research
pub_type： 撤回出版物
doi：
更新日期：2015-12-15 00:00:00
abstract：:Cancer is a diverse class of diseases characterized by uncontrolled cell growth with the potential to invade and spread to other parts of the body, and continues to be one of the leading causes of death worldwide. Conventional cancer treatment modalities include antitumor drugs, surgical resection, locally targeted th...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2019-08-01 00:00:00
abstract：:MicroRNA-122 (miR-122) has been implicated in tumor development and progression in various types of cancers. However, the biological function and regulatory mechanisms of miR-122 in gastric cancer (GC) remain largely unknown. We aimed to determine the biological role and underlying mechanism of miR-122 in GC. Real tim...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:malignant peritoneal mesothelioma (MPM) is a rare peritoneal mesothelial neoplasm. Ki67 and BCL2 are established prognostic markers in several cancers. High Ki67 expression indicates tumour progression, whilst similar expression of BCL2 retards tumour replication. Traditionally, prognosis in MPM is gauged wi...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2013-08-14 00:00:00
abstract：:Pancreatic cancer (PC) is one of the most common gastrointestinal malignancies that are highly aggressive with a low 5-year survival rate. Accumulated evidence has indicated that decoy receptor 3 (DcR3) is involved in several pathologic processes and various cancers. However, the mechanisms underlying dysregulated DcR...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-12-01 00:00:00
abstract：:Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine that serves many roles in inflammation and immunity; however, it is also involved in carcinogenesis. This is a review of the clinical and experimental data published on MIF and its role in various types of cancers such as glioblastomas, lung canc...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-12-01 00:00:00
abstract：:Chronic inflammation is a well-recognized pathogenic factor in tumor initiation and progression. Mice lacking the pro-oncogenic transcription factor STAT3 were shown to be protected from both colitis-associated and epidermal cancers induced by the AOM/DSS and DMBA/TPA protocols, respectively. However, these murine mod...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-09-06 00:00:00
abstract：:The development of new cancer therapeutics would benefit from incorporating efficient tumor models that mimic human disease. We have developed a subcutaneous bladder tumor regeneration system that recapitulates primary human bladder tumor architecture by recombining benign human fetal bladder stromal cells with SW780 ...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Thyroid cancer is the most common endocrine malignancy. Although an association between inflammation and thyroid cancer has long been recognized, a cause-effect relationship at the molecular level has yet to be elucidated. We explored how inflammation could contribute to thyroid carcinogenesis in ThrbPV/PVPten+/- mice...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-07-01 00:00:00
abstract：:The high-mobility group A protein 2 (HMGA2) is a non-histone chromatin factor highly expressed in fetal tissue and malignant tumors but rarely detected within normal adult tissues. The clinical implications and biological functions of HMGA2 in endometrial carcinoma are largely unknown. Here we report that HMGA2 expres...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-01-15 00:00:00
abstract：:[This retracts the article on p. 314 in vol. 10, PMID: 32064170.]. ...
journal_title：American journal of cancer research
pub_type： 杂志文章,撤回出版物
doi：
更新日期：2020-08-01 00:00:00
abstract：:Gastric carcinoma is one of the most lethal malignancies of cancers and its prognosis remains dismal due to the paucity of effective therapeutic targets. Herein, we showed that HRAS is markedly up-regulated in gastric carcinoma. Prognostic analysis indicated that HRAS expression might be a prognostic indicator for the...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2016-09-01 00:00:00
abstract：:Adrenergic receptors (ARs), especially β-ARs, are constitutively expressed in most mammalian cells and are associated with various malignancies including lung cancer. Epidemiologic studies have reported that activation of β-AR signalling promotes the development and progression of lung cancer and that pharmacological ...
journal_title：American journal of cancer research
pub_type： 杂志文章,评审
doi：
更新日期：2018-11-01 00:00:00
abstract：:Despite remaining uncertainties and ongoing research it is possible to draw up a model for the role of (cancer) stem cells in both the initiation and progression of cancer towards metastasis. The cancer stem cell of origin and the cancer stem cell are, despite phenotypic similarities, genotypically different entities....
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：:Colorectal cancer is one of the most commonly diagnosed malignancies among males and females worldwide. Although China is a country with a low incidence of colorectal cancer, with the improvement of China's economy and lifestyle changes, the incidence rate in China has generally increased in recent years, and the morb...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2019-11-01 00:00:00
abstract：:Endometrial cancer (EC) is the most common gynecological malignancy in women and is the leading cause of cancer-related deaths worldwide. Estrogenic stimulation significantly increases endometrial cell proliferation, and both insulin resistance and hyperinsulinemia are associated with the development of EC in women. I...
journal_title：American journal of cancer research
pub_type： 杂志文章
doi：
更新日期：2014-01-15 00:00:00
