解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Hypercholesterolemia is a causal and modifiable risk factor for atherosclerotic cardiovascular disease. A critical pathway regulating cholesterol homeostasis involves the receptor-mediated endocytosis of low-density lipoproteins into hepatocytes, mediated by the LDL receptor. We applied genome-scale CRISPR screening t...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1009285
更新日期:2021-01-29 00:00:00
abstract::Although kinetochores normally play a key role in sister chromatid separation and segregation, chromosome fragments lacking kinetochores (acentrics) can in some cases separate and segregate successfully. In Drosophila neuroblasts, acentric chromosomes undergo delayed, but otherwise normal sister separation, revealing ...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1009304
更新日期:2021-01-29 00:00:00
abstract::70 kDa heat shock proteins (Hsp70) are essential chaperones of the protein quality control network; vital for cellular fitness and longevity. The four cytosolic Hsp70's in yeast, Ssa1-4, are thought to be functionally redundant but the absence of Ssa1 and Ssa2 causes a severe reduction in cellular reproduction and acc...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008951
更新日期:2021-01-11 00:00:00
abstract::Studies of the severely pancytopenic scat mouse model first demonstrated the crucial role of RASA3, a dual RAS and RAP GTPase activating protein (GAP), in hematopoiesis. RASA3 is required for survival in utero; germline deletion is lethal at E12.5-13.5 due to severe hemorrhage. Here, conditional deletion in hematopoie...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008857
更新日期:2020-12-28 00:00:00
abstract::Most B cell lymphomas originate from B cells that have germinal center (GC) experience and bear chromosome translocations and numerous point mutations. GC B cells remodel their immunoglobulin (Ig) genes by somatic hypermutation (SHM) and class switch recombination (CSR) in their Ig genes. Activation Induced Deaminase ...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008960
更新日期:2020-12-23 00:00:00
abstract::The genetic origin of human skin pigmentation remains an open question in biology. Several skin disorders and diseases originate from mutations in conserved pigmentation genes, including albinism, vitiligo, and melanoma. Teleosts possess the capacity to modify their pigmentation to adapt to their environmental backgro...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1009244
更新日期:2020-12-10 00:00:00
abstract::Organisms living in seasonally variable environments utilize cues such as light and temperature to induce plastic responses, enabling them to exploit favorable seasons and avoid unfavorable ones. Local adapation can result in variation in seasonal responses, but the genetic basis and evolutionary history of this varia...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1009110
更新日期:2020-11-20 00:00:00
abstract::Although DNA methylation is the best characterized epigenetic mark, the mechanism by which it is targeted to specific regions in the genome remains unclear. Recent studies have revealed that local DNA methylation profiles might be dictated by cis-regulatory DNA sequences that mainly operate via DNA-binding factors. Co...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1009189
更新日期:2020-11-20 00:00:00
abstract::Many studies have demonstrated the clinical utility and importance of epilepsy gene panel testing to confirm the specific aetiology of disease, enable appropriate therapeutic interventions, and inform accurate family counselling. Previously, SCN9A gene variants, in particular a c.1921A>T p.(Asn641Tyr) substitution, ha...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1009161
更新日期:2020-11-20 00:00:00
abstract::Mitotic divisions depend on the timely assembly and proper orientation of the mitotic spindle. Malfunctioning of these processes can considerably delay mitosis, thereby compromising tissue growth and homeostasis, and leading to chromosomal instability. Loss of functional Mms19 drastically affects the growth and develo...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008913
更新日期:2020-11-19 00:00:00
abstract::Polygenic scores are increasingly powerful predictors of educational achievement. It is unclear, however, how sets of polygenic scores, which partly capture environmental effects, perform jointly with sets of environmental measures, which are themselves heritable, in prediction models of educational achievement. Here,...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1009153
更新日期:2020-11-17 00:00:00
abstract::Phenotypes extracted from Electronic Health Records (EHRs) are increasingly prevalent in genetic studies. EHRs contain hundreds of distinct clinical laboratory test results, providing a trove of health data beyond diagnoses. Such lab data is complex and lacks a ubiquitous coding scheme, making it more challenging than...
journal_title:PLoS genetics
pub_type: 杂志文章,meta分析
doi:10.1371/journal.pgen.1009077
更新日期:2020-11-11 00:00:00
abstract::The liver possesses a remarkable regenerative capacity based partly on the ability of hepatocytes to re-enter the cell cycle and divide to replace damaged cells. This capability is substantially reduced upon chronic damage, but it is not clear if this is a cause or consequence of liver disease. Here, we investigate wh...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1009084
更新日期:2020-11-04 00:00:00
abstract::Orienting the causal relationship between pairs of traits is a fundamental task in scientific research with significant implications in practice, such as in prioritizing molecular targets and modifiable risk factors for developing therapeutic and interventional strategies for complex diseases. A recent method, called ...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1009105
更新日期:2020-11-02 00:00:00
abstract::Adult skeletal muscles are maintained during homeostasis and regenerated upon injury by muscle stem cells (MuSCs). A heterogeneity in self-renewal, differentiation and regeneration properties has been reported for MuSCs based on their anatomical location. Although MuSCs derived from extraocular muscles (EOM) have a hi...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1009022
更新日期:2020-10-30 00:00:00
abstract::Blood vessels are vital to sustain life in all vertebrates. While it is known that mural cells (pericytes and smooth muscle cells) regulate vascular integrity, the contribution of other cell types to vascular stabilization has been largely unexplored. Using zebrafish, we identified sclerotome-derived perivascular fibr...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008800
更新日期:2020-10-26 00:00:00
abstract::The 2,2,7-trimethylguanosine (TMG) cap is one of the first identified modifications on eukaryotic RNAs. TMG, synthesized by the conserved Tgs1 enzyme, is abundantly present on snRNAs essential for pre-mRNA splicing. Results from ex vivo experiments in vertebrate cells suggested that TMG ensures nuclear localization of...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1009098
更新日期:2020-10-21 00:00:00
abstract::Mating-type switching is a complex mechanism that promotes sexual reproduction in Saccharomycotina. In the model species Saccharomyces cerevisiae, mating-type switching is initiated by the Ho endonuclease that performs a site-specific double-strand break (DSB) at MAT, repaired by homologous recombination (HR) using on...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008627
更新日期:2020-10-15 00:00:00
abstract::Genetic surveillance of malaria parasites supports malaria control programmes, treatment guidelines and elimination strategies. Surveillance studies often pose questions about malaria parasite ancestry (e.g. how antimalarial resistance has spread) and employ statistical methods that characterise parasite population st...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1009037
更新日期:2020-10-09 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pgen.1008367.]. ...
journal_title:PLoS genetics
pub_type: 已发布勘误
doi:10.1371/journal.pgen.1009131
更新日期:2020-10-08 00:00:00
abstract::The requirements for oocyte meiotic cytokinesis during polar body extrusion are not well understood. In particular, the relationship between the oocyte meiotic spindle and polar body contractile ring dynamics remains largely unknown. We have used live cell imaging and spindle assembly defective mutants lacking the fun...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008751
更新日期:2020-10-07 00:00:00
abstract::Qsp1 is a secreted quorum sensing peptide required for virulence of the fungal meningitis pathogen Cryptococcus neoformans. Qsp1 functions to control cell wall integrity in vegetatively growing cells and also functions in mating. Rather than acting on a cell surface receptor, Qsp1 is imported to act intracellularly vi...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008744
更新日期:2020-09-21 00:00:00
abstract::Some imprinted genes exhibit parental origin specific expression bias rather than being transcribed exclusively from one copy. The physiological relevance of this remains poorly understood. In an analysis of brain-specific allele-biased expression, we identified that Trappc9, a cellular trafficking factor, was express...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008916
更新日期:2020-09-02 00:00:00
abstract::The ascomycete Trichoderma reesei is a highly prolific cellulase producer. While XYR1 (Xylanase regulator 1) has been firmly established to be the master activator of cellulase gene expression in T. reesei, its precise transcriptional activation mechanism remains poorly understood. In the present study, TrGAL11, a com...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008979
更新日期:2020-09-02 00:00:00
abstract::Identifying regions of positive selection in genomic data remains a challenge in population genetics. Most current approaches rely on comparing values of summary statistics calculated in windows. We present an approach termed SURFDAWave, which translates measures of genetic diversity calculated in genomic windows to f...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008896
更新日期:2020-08-27 00:00:00
abstract::High glucose diets are unhealthy, although the mechanisms by which elevated glucose is harmful to whole animal physiology are not well understood. In Caenorhabditis elegans, high glucose shortens lifespan, while chemically inflicted glucose restriction promotes longevity. We investigated the impact of glucose metaboli...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008982
更新日期:2020-08-25 00:00:00
abstract::Genome-wide association studies (GWAS) have successfully identified tens of thousands of genetic variants associated with various phenotypes, but together they explain only a fraction of heritability, suggesting many variants have yet to be discovered. Recently it has been recognized that incorporating functional info...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008947
更新日期:2020-08-24 00:00:00
abstract::Apolipoprotein B-containing lipoproteins (B-lps) are essential for the transport of hydrophobic dietary and endogenous lipids through the circulation in vertebrates. Zebrafish embryos produce large numbers of B-lps in the yolk syncytial layer (YSL) to move lipids from yolk to growing tissues. Disruptions in B-lp produ...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008941
更新日期:2020-08-06 00:00:00
abstract::Mitochondrial translation defects can be due to mutations affecting mitochondrial- or nuclear-encoded components. The number of known nuclear genes involved in mitochondrial translation has significantly increased in the past years. RCC1L (WBSCR16), a putative GDP/GTP exchange factor, has recently been described to in...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008923
更新日期:2020-07-31 00:00:00
abstract::Neurofibromatosis type 1 is a monogenetic disorder that predisposes individuals to tumor formation and cognitive and behavioral symptoms. The neuronal circuitry and developmental events underlying these neurological symptoms are unknown. To better understand how mutations of the underlying gene (NF1) drive behavioral ...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008920
更新日期:2020-07-22 00:00:00
abstract::Transposable elements (TEs) are genomic parasites that selfishly replicate at the expense of host fitness. Fifty years of evolutionary studies of TEs have concentrated on the deleterious genetic effects of TEs, such as their effects on disrupting genes and regulatory sequences. However, a flurry of recent work suggest...
journal_title:PLoS genetics
pub_type: 杂志文章,评审
doi:10.1371/journal.pgen.1008872
更新日期:2020-07-16 00:00:00
abstract::Fpr1 (FK506-sensitive proline rotamase 1), a protein of the FKBP12 (FK506-binding protein 12 kDa) family in Saccharomyces cerevisiae, is a primary target for the immunosuppressive agents FK506 and rapamycin. Fpr1 inhibits calcineurin and TORC1 (target of rapamycin complex 1) when bound to FK506 and rapamycin, respecti...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008865
更新日期:2020-06-30 00:00:00
abstract::Meiotic crossovers (COs) are important for reshuffling genetic information between homologous chromosomes and they are essential for their correct segregation. COs are unevenly distributed along chromosomes and the underlying mechanisms controlling CO localization are not well understood. We previously showed that mei...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008894
更新日期:2020-06-29 00:00:00
abstract::Cytosine methylation is an ancient epigenetic modification yet its function and extent within genomes is highly variable across eukaryotes. In mammals, methylation controls transposable elements and regulates the promoters of genes. In insects, DNA methylation is generally restricted to a small subset of transcribed g...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008864
更新日期:2020-06-25 00:00:00
abstract::The circadian clocks in chlorophyte algae have been studied in two model organisms, Chlamydomonas reinhardtii and Ostreococcus tauri. These studies revealed that the chlorophyte clocks include some genes that are homologous to those of the angiosperm circadian clock. However, the genetic network architectures of the c...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008814
更新日期:2020-06-17 00:00:00
abstract::In metazoan germlines, the piRNA pathway acts as a genomic immune system, employing small RNA-mediated silencing to defend host DNA from the harmful effects of transposable elements (TEs). Expression of genomic TEs is proposed to initiate self regulation by increasing the production of repressive piRNAs, thereby "adap...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008861
更新日期:2020-06-11 00:00:00
abstract::Insecticide resistance in malaria vectors threatens to reverse recent gains in malaria control. Deciphering patterns of gene flow and resistance evolution in malaria vectors is crucial to improving control strategies and preventing malaria resurgence. A genome-wide survey of Anopheles funestus genetic diversity Africa...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008822
更新日期:2020-06-04 00:00:00
abstract::Late-Onset Alzheimer's disease (LOAD) is a common, complex genetic disorder well-known for its heterogeneous pathology. The genetic heterogeneity underlying common, complex diseases poses a major challenge for targeted therapies and the identification of novel disease-associated variants. Case-control approaches are o...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008775
更新日期:2020-06-03 00:00:00
abstract::Hormone-dependent activation of enhancers includes histone hyperacetylation and mediator recruitment. Histone hyperacetylation is mostly explained by a bimodal switch model, where histone deacetylases (HDACs) disassociate from chromatin, and histone acetyl transferases (HATs) are recruited. This model builds on decade...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008770
更新日期:2020-05-26 00:00:00
abstract::The genetics of domestication has been extensively studied ever since the rediscovery of Mendel's law of inheritance and much has been learned about the genetic control of trait differences between crops and their ancestors. Here, we ask how domestication has altered genetic architecture by comparing the genetic archi...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008791
更新日期:2020-05-14 00:00:00