Abstract:
:The genetics of domestication has been extensively studied ever since the rediscovery of Mendel's law of inheritance and much has been learned about the genetic control of trait differences between crops and their ancestors. Here, we ask how domestication has altered genetic architecture by comparing the genetic architecture of 18 domestication traits in maize and its ancestor teosinte using matched populations. We observed a strongly reduced number of QTL for domestication traits in maize relative to teosinte, which is consistent with the previously reported depletion of additive variance by selection during domestication. We also observed more dominance in maize than teosinte, likely a consequence of selective removal of additive variants. We observed that large effect QTL have low minor allele frequency (MAF) in both maize and teosinte. Regions of the genome that are strongly differentiated between teosinte and maize (high FST) explain less quantitative variation in maize than teosinte, suggesting that, in these regions, allelic variants were brought to (or near) fixation during domestication. We also observed that genomic regions of high recombination explain a disproportionately large proportion of heritable variance both before and after domestication. Finally, we observed that about 75% of the additive variance in both teosinte and maize is "missing" in the sense that it cannot be ascribed to detectable QTL and only 25% of variance maps to specific QTL. This latter result suggests that morphological evolution during domestication is largely attributable to very large numbers of QTL of very small effect.
journal_name
PLoS Genetjournal_title
PLoS geneticsauthors
Chen Q,Samayoa LF,Yang CJ,Bradbury PJ,Olukolu BA,Neumeyer MA,Romay MC,Sun Q,Lorant A,Buckler ES,Ross-Ibarra J,Holland JB,Doebley JFdoi
10.1371/journal.pgen.1008791subject
Has Abstractpub_date
2020-05-14 00:00:00pages
e1008791issue
5eissn
1553-7390issn
1553-7404pii
PGENETICS-D-20-00254journal_volume
16pub_type
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