Abstract:
:[This corrects the article DOI: 10.1371/journal.pgen.1008367.].
journal_name
PLoS Genetjournal_title
PLoS geneticsauthors
Baker RL,Leong WF,Brock MT,Rubin MJ,Markelz RJC,Welch S,Maloof JN,Weinig Cdoi
10.1371/journal.pgen.1009131subject
Has Abstractpub_date
2020-10-08 00:00:00pages
e1009131issue
10eissn
1553-7390issn
1553-7404pii
PGENETICS-D-20-01479journal_volume
16pub_type
已发布勘误相关文献
PLoS Genetics文献大全abstract::Zinc is an essential trace element involved in a wide range of biological processes and human diseases. Zinc excess is deleterious, and animals require mechanisms to protect against zinc toxicity. To identify genes that modulate zinc tolerance, we performed a forward genetic screen for Caenorhabditis elegans mutants t...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1002013
更新日期:2011-03-01 00:00:00
abstract::Nonhomologous end-joining (NHEJ) is the primary DNA repair pathway thought to underlie chromosomal translocations and other genomic rearrangements in somatic cells. The canonical NHEJ pathway, including DNA ligase IV (Lig4), suppresses genomic instability and chromosomal translocations, leading to the notion that a po...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1002080
更新日期:2011-06-01 00:00:00
abstract::A relatively unexplored nexus in Drosophila Immune deficiency (IMD) pathway is TGF-beta Activating Kinase 1 (TAK1), which triggers both immunity and apoptosis. In a cell culture screen, we identified that Lysine at position 142 was a K63-linked Ubiquitin acceptor site for TAK1, required for signalling. Moreover, Lysin...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1004117
更新日期:2014-02-20 00:00:00
abstract::Endoreplication is a cell cycle variant that entails cell growth and periodic genome duplication without cell division, and results in large, polyploid cells. Cells switch from mitotic cycles to endoreplication cycles during development, and also in response to conditional stimuli during wound healing, regeneration, a...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008253
更新日期:2019-07-10 00:00:00
abstract::Mutations in the human LMNA gene cause muscular dystrophy by mechanisms that are incompletely understood. The LMNA gene encodes A-type lamins, intermediate filaments that form a network underlying the inner nuclear membrane, providing structural support for the nucleus and organizing the genome. To better understand t...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1005231
更新日期:2015-05-21 00:00:00
abstract::Organisms living in seasonally variable environments utilize cues such as light and temperature to induce plastic responses, enabling them to exploit favorable seasons and avoid unfavorable ones. Local adapation can result in variation in seasonal responses, but the genetic basis and evolutionary history of this varia...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1009110
更新日期:2020-11-20 00:00:00
abstract::Salt stress is an important environmental factor that significantly limits crop productivity worldwide. Studies on responses of plants to salt stress in recent years have identified novel signaling pathways and have been at the forefront of plant stress biology and plant biology in general. Thus far, research on salt ...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1003755
更新日期:2013-08-01 00:00:00
abstract::PCNA ubiquitylation on lysine 164 is required for DNA damage tolerance. In many organisms PCNA is also ubiquitylated in unchallenged S phase but the significance of this has not been established. Using Schizosaccharomyces pombe, we demonstrate that lysine 164 ubiquitylation of PCNA contributes to efficient DNA replica...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1006789
更新日期:2017-05-08 00:00:00
abstract::The Anaplastic Lymphoma Kinase (Alk) receptor tyrosine kinase (RTK) plays a critical role in the specification of founder cells (FCs) in the Drosophila visceral mesoderm (VM) during embryogenesis. Reporter gene and CRISPR/Cas9 deletion analysis reveals enhancer regions in and upstream of the Alk locus that influence t...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1006617
更新日期:2017-04-03 00:00:00
abstract::Complex traits are known to be influenced by a combination of environmental factors and rare and common genetic variants. However, detection of such multivariate associations can be compromised by low statistical power and confounding by population structure. Linear mixed effects models (LMM) can account for correlati...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008766
更新日期:2020-05-04 00:00:00
abstract::Because cohesion prevents sister-chromatid separation and spindle elongation, cohesion dissolution may trigger these two events simultaneously. However, the relatively normal spindle elongation kinetics in yeast cohesin mutants indicates an additional mechanism for the temporal control of spindle elongation. Here we s...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1003319
更新日期:2013-01-01 00:00:00
abstract::Gene expression can be highly heterogeneous in isogenic cell populations. An extreme type of heterogeneity is the so-called bistable or bimodal expression, whereby a cell can differentiate into two alternative expression states. Stochastic fluctuations of protein levels, also referred to as noise, provide the necessar...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1005047
更新日期:2015-06-25 00:00:00
abstract::The extent that both positive and negative selection vary across different portions of plant genomes remains poorly understood. Here, we sequence whole genomes of 13 Capsella grandiflora individuals and quantify the amount of selection across the genome. Using an estimate of the distribution of fitness effects, we sho...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1004622
更新日期:2014-09-25 00:00:00
abstract::Most genetic variants associated with disease occur within regulatory regions of the genome, underscoring the importance of defining the mechanisms underlying differences in regulation of gene expression between individuals. We discovered a pair of co-regulated, divergently oriented transcripts, AQY2 and ncFRE6, that ...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1005746
更新日期:2016-01-11 00:00:00
abstract::Monospermic fertilization is mediated by the extracellular zona pellucida composed of ZP1, ZP2 and ZP3. Sperm bind to the N-terminus of ZP2 which is cleaved after fertilization by ovastacin (encoded by Astl) exocytosed from egg cortical granules to prevent sperm binding. AstlNull mice lack the post-fertilization block...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1006580
更新日期:2017-01-23 00:00:00
abstract::In plants, multiple detached tissues are capable of forming a pluripotent cell mass, termed callus, when cultured on media containing appropriate plant hormones. Recent studies demonstrated that callus resembles the root-tip meristem, even if it is derived from aerial organs. This finding improves our understanding of...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1002911
更新日期:2012-08-01 00:00:00
abstract::Malaria parasites follow a complex life cycle that consists of multiple stages that span from the human host to the mosquito vector. Among the species causing malaria, Plasmodium falciparum is the most lethal, with clinical symptoms manifesting during the intraerythrocytic developmental cycle (IDC). During the IDC, P....
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008506
更新日期:2019-12-19 00:00:00
abstract::Meiotic cytokinesis influences the fertility and ploidy of gametes. However, limited information is available on the genetic control of meiotic cytokinesis in plants. Here, we identified a rice mutant with low male fertility, defective callose in meiosis 1 (dcm1). The pollen grains of dcm1 are proved to be defective i...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1007769
更新日期:2018-11-12 00:00:00
abstract::The molecular clock of neutral mutations, which represents linear mutation fixation over generations, is theoretically explained by genetic drift in fitness-steady evolution or hitchhiking in adaptive evolution. The present study is the first experimental demonstration for the molecular clock of neutral mutations in a...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1005392
更新日期:2015-07-15 00:00:00
abstract::The human pathogens N. gonorrhoeae and N. meningitidis display robust intra- and interstrain glycan diversity associated with their O-linked protein glycosylation (pgl) systems. In an effort to better understand the evolution and function of protein glycosylation operating there, we aimed to determine if other human-r...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008532
更新日期:2019-12-23 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Rare genetic mutations in genes such as Parkin, Pink1, DJ-1, α-synuclein, LRRK2 and GBA are found to be responsible for the disease in about 15% of the cases. A key u...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008352
更新日期:2019-08-26 00:00:00
abstract::Genome duplications are important evolutionary events that impact the rate and spectrum of beneficial mutations and thus the rate of adaptation. Laboratory evolution experiments initiated with haploid Saccharomyces cerevisiae cultures repeatedly experience whole-genome duplication (WGD). We report recurrent genome dup...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1007396
更新日期:2018-05-25 00:00:00
abstract::Epigenetic gene silencing plays a critical role in regulating gene expression and contributes to organismal development and cell fate acquisition in eukaryotes. In fission yeast, Schizosaccharomyces pombe, heterochromatin-associated gene silencing is known to be mediated by RNA processing pathways including RNA interf...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1005873
更新日期:2016-02-18 00:00:00
abstract::Zygotic gene expression programs control cell differentiation in vertebrate development. In Xenopus, these programs are initiated by local induction of regulatory genes through maternal signaling activities in the wake of zygotic genome activation (ZGA) at the midblastula transition (MBT). These programs lay down the ...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1006757
更新日期:2017-05-12 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pgen.1006425.]. ...
journal_title:PLoS genetics
pub_type: 杂志文章,已发布勘误
doi:10.1371/journal.pgen.1006831
更新日期:2017-06-07 00:00:00
abstract::Anti-tumor necrosis factor alpha (anti-TNF) biologic therapy is a widely used treatment for rheumatoid arthritis (RA). It is unknown why some RA patients fail to respond adequately to anti-TNF therapy, which limits the development of clinical biomarkers to predict response or new drugs to target refractory cases. To u...
journal_title:PLoS genetics
pub_type: 杂志文章,meta分析
doi:10.1371/journal.pgen.1003394
更新日期:2013-03-01 00:00:00
abstract::Considerable evidence now supports the idea that the moderate telomere lengthening produced by recombinational telomere elongation (RTE) in a Kluyveromyces lactis telomerase deletion mutant occurs through a roll-and-spread mechanism. However, it is unclear whether this mechanism can account for other forms of RTE that...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1003017
更新日期:2012-01-01 00:00:00
abstract::Human growth has an estimated heritability of about 80%-90%. Nevertheless, the underlying cause of shortness of stature remains unknown in the majority of individuals. Genome-wide association studies (GWAS) showed that both common single nucleotide polymorphisms and copy number variants (CNVs) contribute to height var...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1003365
更新日期:2013-01-01 00:00:00
abstract::Cdc6p is an essential component of the pre-replicative complex (pre-RC), which binds to DNA replication origins to promote initiation of DNA replication. Only once per cell cycle does DNA replication take place. After initiation, the pre-RC components are disassembled in order to prevent re-replication. It has been sh...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1003099
更新日期:2012-01-01 00:00:00
abstract::Using small molecule probes to understand gene function is an attractive approach that allows functional characterization of genes that are dispensable in standard laboratory conditions and provides insight into the mode of action of these compounds. Using chemogenomic assays we previously identified yeast Crg1, an un...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1002332
更新日期:2011-10-01 00:00:00