Abstract:
:Qsp1 is a secreted quorum sensing peptide required for virulence of the fungal meningitis pathogen Cryptococcus neoformans. Qsp1 functions to control cell wall integrity in vegetatively growing cells and also functions in mating. Rather than acting on a cell surface receptor, Qsp1 is imported to act intracellularly via the predicted oligopeptide transporter Opt1. Here, we identify a transcription factor network as a target of Qsp1. Using whole-genome chromatin immunoprecipitation, we find Qsp1 controls the genomic associations of three transcription factors to genes whose outputs are regulated by Qsp1. One of these transcription factors, Cqs2, is also required for the action of Qsp1 during mating, indicating that it might be a shared proximal target of Qsp1. Consistent with this hypothesis, deletion of CQS2 impacts the binding of other network transcription factors specifically to Qsp1-regulated genes. These genetic and genomic studies illuminate mechanisms by which an imported peptide acts to modulate eukaryotic gene expression.
journal_name
PLoS Genetjournal_title
PLoS geneticsauthors
Summers DK,Perry DS,Rao B,Madhani HDdoi
10.1371/journal.pgen.1008744subject
Has Abstractpub_date
2020-09-21 00:00:00pages
e1008744issue
9eissn
1553-7390issn
1553-7404pii
PGENETICS-D-20-00459journal_volume
16pub_type
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