abstract：:Stimulation of thermogenesis in brown adipose tissue (BAT) could have far-reaching health benefits in combatting obesity and obesity-related complications. Apolipoprotein A-IV (ApoA-IV), produced by the gut and the brain in the presence of dietary lipids, is a well-known short-term satiating protein. While our previou...

journal_title：International journal of molecular sciences

authors： Pence S,LaRussa Z,Shen Z,Liu M,Coschigano KT,Shi H,Lo CC

更新日期：2021-01-27 00:00:00

abstract：:Nowadays, it is well accepted that inflammation is a critical player in cancer, being, in most cases, the main character of the process. Different types of tumor arise from sites of infection or chronic inflammation. This non-resolving inflammation is responsible for tumor development at different levels: it promotes ...

journal_title：International journal of molecular sciences

authors： Digifico E,Balinzo S,Belgiovine C

更新日期：2021-01-27 00:00:00

abstract：:Background: To evaluate the distribution of the transforming growth factor-beta induced (TGFBI) corneal dystrophies in a multi-ethnic population in Singapore, and to present the different phenotypes with the same genotype. Methods: This study included 32 patients. Slit lamp biomicroscopy was performed for each patient...

journal_title：International journal of molecular sciences

authors： Han SB,Anandalakshmi V,Wong CW,Ng SR,Mehta JS

更新日期：2021-01-27 00:00:00

abstract：:In advanced cirrhosis, the TNFα-mediated intestinal inflammation and bacteria dysbiosis are involved in the development of inflammation and vasoconstriction-related renal dysfunction. In colitis and acute kidney injury models, activation of SIRT1 attenuates the TNFα-mediated intestinal and renal abnormalities. This st...

journal_title：International journal of molecular sciences

authors： Chou YT,Liu TT,Yang UC,Huang CC,Liu CW,Huang SF,Li TH,Liu HM,Lin MW,Yang YY,Lee TY,Huang YH,Hou MC,Lin HC

更新日期：2021-01-27 00:00:00

abstract：BACKGROUND:A growing body of data indicates that the physiology of the liver is sex-hormone dependent, with some types of liver failure occurring more frequently in males, and some in females. In males, in physiological conditions, testosterone acts via androgen receptors (AR) to increase insulin receptor (IR) expressi...

journal_title：International journal of molecular sciences

authors： Kur P,Kolasa-Wołosiuk A,Grabowska M,Kram A,Tarnowski M,Baranowska-Bosiacka I,Rzeszotek S,Piasecka M,Wiszniewska B

更新日期：2021-01-27 00:00:00

abstract：:Down syndrome (DS) or trisomy of chromosome 21 (Hsa21) is characterized by impaired hippocampal-dependent learning and memory. These alterations are due to defective neurogenesis and to neuromorphological and functional anomalies of numerous neuronal populations, including hippocampal granular cells (GCs). It has been...

journal_title：International journal of molecular sciences

authors： Puente-Bedia A,Berciano MT,Tapia O,Martínez-Cué C,Lafarga M,Rueda N

更新日期：2021-01-27 00:00:00

abstract：:Recent studies have identified cyclic GMP-AMP synthase (cGAS) as an important target for treating autoimmune diseases, and several inhibitors of human cGAS (hcGAS) and their structures in complexation with hcGAS have been reported. However, the mechanisms via which these inhibitors interact with hcGAS are not complete...

journal_title：International journal of molecular sciences

authors： Wang X,Li W

更新日期：2021-01-25 00:00:00

abstract：:In previous work, a 93-mer aptamer was selected against the anaphylactic allergen, β-conglutin and truncated to an 11-mer, improving the affinity by two orders of magnitude, whilst maintaining the specificity. This 11-mer was observed to fold in a G-quadruplex, and preliminary results indicated the existence of a comb...

journal_title：International journal of molecular sciences

authors： Sullivan CKO,Mairal T,Jauset-Rubio M,Svobodova M,Skouridou V,Esposito V,Virgilio A,Galeone A

更新日期：2021-01-24 00:00:00

abstract：:Soluble receptors are widely understood to be freestanding moieties formed via cleavage from their membrane-bound counterparts. They have unique structures, are found among various receptor families, and have intriguing mechanisms of generation and release. Soluble receptors' ability to exhibit pleiotropic action by r...

journal_title：International journal of molecular sciences

authors： Bhattacharya A,Ashouri R,Fangman M,Mazur A,Garett T,Doré S

更新日期：2021-01-23 00:00:00

abstract：:Chronic immune response to bone implant may lead to delayed healing and its failure. Thus, newly developed biomaterials should be characterized by high biocompatibility. Moreover, it is well known that macrophages play a crucial role in the controlling of biomaterial-induced inflammatory response. Immune cells synthes...

journal_title：International journal of molecular sciences

authors： Kazimierczak P,Koziol M,Przekora A

更新日期：2021-01-23 00:00:00

abstract：:The silencing of thyroid-related genes presents difficulties in radioiodine therapy for anaplastic thyroid cancers (ATCs). Tunicamycin (TM), an N-linked glycosylation inhibitor, is an anticancer drug. Herein, we investigated TM-induced restoration of responsiveness to radioiodine therapy in radioiodine refractory ATCs...

journal_title：International journal of molecular sciences

authors： Choi YJ,Lee JE,Ji HD,Lee BR,Lee SB,Kim KS,Lee IK,Chin J,Cho SJ,Lee J,Lee SW,Ha JH,Jeon YH

更新日期：2021-01-22 00:00:00

abstract：:Patients harbouring mutations in genes encoding C-type natriuretic peptide (CNP; NPPC) or its receptor guanylyl cyclase B (GC-B, NPR2) suffer from severe growth phenotypes; loss-of-function mutations cause achondroplasia, whereas gain-of-function mutations cause skeletal overgrowth. Although most of the effects of CNP...

journal_title：International journal of molecular sciences

authors： Mirczuk SM,Scudder CJ,Read JE,Crossley VJ,Regan JT,Richardson KM,Simbi B,McArdle CA,Church DB,Fenn J,Kenny PJ,Volk HA,Wheeler-Jones CP,Korbonits M,Niessen SJ,McGonnell IM,Fowkes RC

更新日期：2021-01-22 00:00:00

abstract：:The majority of the human genome is comprised of non-protein-coding genes, but the relevance of non-coding RNAs in complex diseases has yet to be fully elucidated. One class of non-coding RNAs is long non-coding RNAs or lncRNAs, many of which have been identified to play a range of roles in transcription and translati...

journal_title：International journal of molecular sciences

authors： Wilson C,Kanhere A

更新日期：2021-01-22 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs with a known role as mediators of gene expression in crucial biological processes, which converts them into high potential contenders in the ongoing search for effective therapeutic strategies. However, extracellular RNAs are unstable and rapidly degraded, reducing the poss...

journal_title：International journal of molecular sciences

authors： Del Pozo-Acebo L,Hazas MLL,Tomé-Carneiro J,Gil-Cabrerizo P,San-Cristobal R,Busto R,García-Ruiz A,Dávalos A

更新日期：2021-01-22 00:00:00

abstract：:Bacterial pathogens expose on the cell surface a variety of complex carbohydrate molecules. Gram-negative bacteria produce lipopolysaccharides, which are the main components of the outer membrane of bacterial envelopes and play a major role in host-pathogen interactions. B. pertussis, B. parapertussis, B. bronchisepti...

journal_title：International journal of molecular sciences

authors： Ucieklak K,Koj S,Niedziela T

更新日期：2021-01-21 00:00:00

abstract：:Amyloid A (AA) amyloidosis is a condition in which amyloid fibrils characterized by a linear morphology and a cross-β structure accumulate and are deposited extracellularly in organs, resulting in chronic inflammatory diseases and infections. The incidence of AA amyloidosis is high in humans and several animal species...

journal_title：International journal of molecular sciences

authors： Lin X,Watanabe K,Kuragano M,Tokuraku K

更新日期：2021-01-21 00:00:00

abstract：:Calcium-dependent protein kinase (CDPK or CPK) and CDPK-related kinase (CRK) play an important role in plant growth, development, and adaptation to environmental stresses. However, their gene families had been yet inadequately investigated in Medicago truncatula. In this study, six MtCRK genes were computationally ide...

journal_title：International journal of molecular sciences

authors： Zhao P,Liu Y,Kong W,Ji J,Cai T,Guo Z

更新日期：2021-01-21 00:00:00

abstract：:The insulin signaling (IIS) pathway plays an important role in the metabolism, growth, development, reproduction, and longevity of an organism. As a key member of the IIS pathway, insulin-like growth factor binding proteins (IGFBPs) are widely distributed a family in invertebrates and vertebrates that are critical in ...

journal_title：International journal of molecular sciences

authors： Pang Y,Zhang X,Yuan J,Zhang X,Xiang J,Li F

更新日期：2021-01-21 00:00:00

abstract：:Inflammasomes are components of the innate immune response that have recently emerged as crucial controllers of tissue homeostasis. In particular, the nucleotide-binding domain, leucine-rich-containing (NLR) family pyrin domain containing 3 (NLRP3) inflammasome is a complex platform involved in the activation of caspa...

journal_title：International journal of molecular sciences

authors： De Miguel C,Pelegrín P,Baroja-Mazo A,Cuevas S

更新日期：2021-01-21 00:00:00

abstract：:The introduction of Clearfield technology allows the use of imidazolinone (IMI) herbicides to control weedy rice. Imidazolinone herbicides stop the acetolactate synthase (ALS) enzyme from synthesizing branched-chain amino acids, resulting in the death of the plant. Since the launch of Clearfield technology in Malaysia...

journal_title：International journal of molecular sciences

authors： Yean RA,Dilipkumar M,Rahman S,Song BK

更新日期：2021-01-20 00:00:00

abstract：:Protein inhibitors of proteases are an important tool of nature to regulate and control proteolysis in living organisms under physiological and pathological conditions. In this review, we analyzed the mechanisms of inhibition of cysteine proteases on the basis of structural information and compiled kinetic data. The g...

journal_title：International journal of molecular sciences

authors： Tušar L,Usenik A,Turk B,Turk D

更新日期：2021-01-20 00:00:00

abstract：:Proteins have been used as building blocks to provide various supramolecular structures in efforts to develop nano-biomaterials possessing broad biological functionalities. A series of unique structures have been obtained from the engineering of hemoproteins which contain the iron porphyrin known as heme, as a prosthe...

journal_title：International journal of molecular sciences

authors： Soon JW,Oohora K,Hirayama S,Hayashi T

更新日期：2021-01-20 00:00:00

abstract：:Although the role of platelet-rich plasma (PRP) in tissue regeneration has been confirmed in many studies, the mechanism of this process is still not fully understood. Human keratinocytes (HaCaT) cells were used as an experimental model for studies on the effects of PRP on cell proliferation, migration, collagen biosy...

journal_title：International journal of molecular sciences

authors： Misiura M,Guszczyn T,Oscilowska I,Baszanowska W,Palka J,Miltyk W

更新日期：2021-01-19 00:00:00

abstract：:The forced swim stress test (FST) is widely used for screening pharmacological or non-pharmacological strategies with potential antidepressant activities. Recent data have suggested that repeated FST for five consecutive days (i.e., 5d-RFSS) could be used to generate a robust depressive-like phenotype in mice. However...

journal_title：International journal of molecular sciences

authors： Bullich S,Delcourte S,Haddjeri N,Guiard BP

更新日期：2021-01-19 00:00:00

abstract：:Traumatic brain injury (TBI) modelled by lateral fluid percussion-induction (LFPI) in rats is a widely used experimental rodent model to explore and understand the underlying cellular and molecular alterations in the brain caused by TBI in humans. Current improvements in imaging with positron emission tomography (PET)...

journal_title：International journal of molecular sciences

authors： Ghosh KK,Padmanabhan P,Yang CT,Wang Z,Palanivel M,Ng KC,Lu J,Carlstedt-Duke J,Halldin C,Gulyás B

更新日期：2021-01-19 00:00:00

abstract：:Sex reversal has been used as a breeding strategy by salmonid fish to produce genetically and phenotypically single sex populations. Production of all-female fish has great importance for the creation of monosex female triploids of salmonid fish, which are valued for their sterility, lack of female maturation, and lar...

journal_title：International journal of molecular sciences

authors： Judycka S,Nynca J,Hliwa P,Ciereszko A

更新日期：2021-01-19 00:00:00

abstract：:Controlling the differentiation potential of adipose-derived stem cells (ADSCs) is attracting attention as a new strategy for the prevention and treatment of obesity. Here, we aimed to observe the effect of exercise training (TR) and high-fat diet (HFD) on the metabolic profiles of ADSCs-derived adipocytes. The rats w...

journal_title：International journal of molecular sciences

authors： Osawa S,Kato H,Maeda Y,Takakura H,Ogasawara J,Izawa T

更新日期：2021-01-19 00:00:00

abstract：:Magnesium (Mg)-based biomaterials hold considerable promise for applications in regenerative medicine. However, the degradation of Mg needs to be reduced to control toxicity caused by its rapid natural corrosion. In the process of developing new Mg alloys with various surface modifications, an efficient assessment of ...

journal_title：International journal of molecular sciences

authors： Hartjen P,Wegner N,Ahmadi P,Matthies L,Nada O,Fuest S,Yan M,Knipfer C,Gosau M,Walther F,Smeets R

更新日期：2021-01-19 00:00:00

abstract：:The protein phosphatase PP2A is essential for the control of integrated eukaryotic cell functioning. Several cellular and developmental events, e.g., plant growth regulator (PGR) mediated signaling pathways are regulated by reversible phosphorylation of vesicle traffic proteins. Reviewing present knowledge on the rele...

journal_title：International journal of molecular sciences

authors： Máthé C,M-Hamvas M,Freytag C,Garda T

更新日期：2021-01-19 00:00:00

abstract：:Autocrine signaling is defined as the production and secretion of an extracellular mediator by a cell followed by the binding of that mediator to receptors on the same cell to initiate signaling. Autocrine stimulation often operates in autocrine loops, a type of interaction, in which a cell produces a mediator, for wh...

journal_title：International journal of molecular sciences

authors： Ungefroren H

更新日期：2021-01-19 00:00:00

abstract：:It has been increasingly recognized that SNAIL1 and SNAIL2, as major EMT-inducers, might also be involved in drug resistance of cancer cells. We sought to determine a relation between SNAIL1/2, E-cadherin and N-cadherin expression, as well as ovarian cancer cells' resistance to cisplatin and EMT markers' level. Thus, ...

journal_title：International journal of molecular sciences

authors： Kielbik M,Szulc-Kielbik I,Klink M

更新日期：2021-01-19 00:00:00

abstract：:Treatment with 1-methylcyclopropylene (1-MCP) is an effective technique to preserve fruits, but inappropriate treatment with 1-MCP causes a ripening disorder (rubbery texture) in papaya fruit. In this study, a combined metabolomic and transcriptomic analysis was conducted to reveal the possible mechanism of the ripeni...

journal_title：International journal of molecular sciences

authors： Zheng S,Hao Y,Fan S,Cai J,Chen W,Li X,Zhu X

更新日期：2021-01-18 00:00:00

abstract：:We herein investigated the detection frequency and clinical relevance of circulating tumor cells (CTCs) in chemotherapy-naïve stage IIIB/IV non-small cell lung cancer (NSCLC), by using the CellSearch and real-time CEACAM5mRNA assays. Blood samples from 43 patients were obtained at different time points during first-li...

journal_title：International journal of molecular sciences

authors： Papadaki MA,Messaritakis I,Fiste O,Souglakos J,Politaki E,Kotsakis A,Georgoulias V,Mavroudis D,Agelaki S

更新日期：2021-01-18 00:00:00

abstract：:We aimed to validate the effect of non-canonical splice site variants in the RPGR gene in five patients from four families diagnosed with retinitis pigmentosa. Four variants located in intron 2 (c.154 + 3_154 + 6del), intron 3 (c.247 + 5G>A), intron 7 (c.779-5T>G), and intron 13 (c.1573-12A>G), respectively, were anal...

journal_title：International journal of molecular sciences

authors： Kortüm F,Kieninger S,Mazzola P,Kohl S,Wissinger B,Prokisch H,Stingl K,Weisschuh N

更新日期：2021-01-16 00:00:00

abstract：:Extracellular vesicles (EVs) are lipid bilayer vesicles which are released from cells and play multifaceted roles in cellular communication in health and disease. EVs can be isolated from various body fluids, including serum and plasma, and are usable biomarkers as they can inform health status. Studies on EVs are an ...

journal_title：International journal of molecular sciences

authors： Magnadóttir B,Kraev I,Dodds AW,Lange S

更新日期：2021-01-16 00:00:00

abstract：:Citrus fruit are sensitive to chilling injury (CI) during cold storage, a peel disorder that causes economic losses. C-repeat binding factors (CBFs) are related to cold acclimation and tolerance in different plants. To explore the role of Citrus CBFs in fruit response to cold, an in silico study was performed, reveali...

journal_title：International journal of molecular sciences

authors： Salvo M,Rey F,Arruabarrena A,Gambetta G,Rodrigo MJ,Zacarías L,Lado J

更新日期：2021-01-15 00:00:00

abstract：:Ethanol abuse is a common issue in individuals with sedentary lifestyles, unbalanced diets, and metabolic syndrome. Both ethanol abuse and metabolic syndrome have negative impacts on the central nervous system, with effects including cognitive impairment and brain oxidative status deterioration. The combined effects o...

journal_title：International journal of molecular sciences

authors： Baliño P,Romero-Cano R,Muriach M

更新日期：2021-01-15 00:00:00

abstract：:Fear extinction requires coordinated neural activity within the amygdala and medial prefrontal cortex (mPFC). Any behavior has a transcriptomic signature that is modified by environmental experiences, and specific genes are involved in functional plasticity and synaptic wiring during fear extinction. Here, we investig...

journal_title：International journal of molecular sciences

authors： Laricchiuta D,Sciamanna G,Gimenez J,Termine A,Fabrizio C,Caioli S,Balsamo F,Panuccio A,De Bardi M,Saba L,Passarello N,Cutuli D,Mattioni A,Zona C,Orlando V,Petrosini L

更新日期：2021-01-15 00:00:00

abstract：:IKAROS, encoded by the IKZF1 gene, is a DNA-binding protein that functions as a tumor suppressor in T cell acute lymphoblastic leukemia (T-ALL). Recent studies have identified IKAROS's novel function in the epigenetic regulation of gene expression in T-ALL and uncovered many genes that are likely to be directly regula...

journal_title：International journal of molecular sciences

authors： Dovat E,Song C,Hu T,Rahman MA,Dhanyamraju PK,Klink M,Bogush D,Soliman M,Kane S,McGrath M,Ding Y,Desai D,Sharma A,Gowda C

更新日期：2021-01-15 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are a promising therapy to improve vascular repair, yet their role in ischemic retinopathy is not fully understood. The aim of this study is to investigate the impact of modulating the neurotrophin receptor; p75NTR on the vascular protection of MSCs in an acute model of retinal ischemia/r...

journal_title：International journal of molecular sciences

authors： Elshaer SL,Park HS,Pearson L,Hill WD,Longo FM,El-Remessy AB

更新日期：2021-01-15 00:00:00