Abstract:
:Ethanol abuse is a common issue in individuals with sedentary lifestyles, unbalanced diets, and metabolic syndrome. Both ethanol abuse and metabolic syndrome have negative impacts on the central nervous system, with effects including cognitive impairment and brain oxidative status deterioration. The combined effects of ethanol abuse and metabolic syndrome at a central level have not yet been elucidated in detail. Thus, this work aims to determine the effects of ethanol intake on a mouse model of metabolic syndrome at the behavioral and biochemical levels. Seven-week-old male control (B6.V-Lep ob/+JRj) and leptin-deficient (metabolic syndrome) (B6.V-Lep ob/obJRj) mice were used in the study. Animals were divided into four groups: control, ethanol, obese, and obese-ethanol. Ethanol consumption was monitored for 6 weeks. Basal glycemia, insulin, and glucose overload tests were performed. To assess short- and long-term memory, an object recognition test was used. In order to assess oxidative status in mouse brain samples, antioxidant enzyme activity was analyzed with regard to glutathione peroxidase, glutathione reductase, glutathione, glutathione disulfide, lipid peroxidation products, and malondialdehyde. Ethanol intake modulated the insulin response and impaired the oxidative status in the ob mouse brain.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Baliño P,Romero-Cano R,Muriach Mdoi
10.3390/ijms22020807subject
Has Abstractpub_date
2021-01-15 00:00:00issue
2issn
1422-0067pii
ijms22020807journal_volume
22pub_type
杂志文章abstract::The interactions of chemokines with their G protein-coupled receptors promote the migration of leukocytes during normal immune function and as a key aspect of the inflammatory response to tissue injury or infection. This review summarizes the major cellular and biochemical mechanisms by which the interactions of chemo...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18020342
更新日期:2017-02-07 00:00:00
abstract::Increasing evidence suggests that the metal homeostasis is involved in the pathogenesis of various neurodegenerative diseases including senile type of dementia such as Alzheimer's disease, dementia with Lewy bodies, and vascular dementia. In particular, synaptic Zn2+ is known to play critical roles in the pathogenesis...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21072570
更新日期:2020-04-07 00:00:00
abstract::Tea (Camellia sinensis L.) is recalcitrant to Agrobacterium-mediated genetic transformation largely due to the bactericidal effects of tea polyphenols and phenolics oxidation induced by necrosis of explant tissue over the process of transformation. In this study, different antioxidants/adsorbents were added as supplem...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17071132
更新日期:2016-07-15 00:00:00
abstract::The molecular mechanism regulating embryo development under reduced oxygen tension remains elusive. This study aimed to identify the molecular mechanism impacting embryo development under low oxygen conditions. Buffalo embryos were cultured under 5% or 20% oxygen and were evaluated according to their morphological par...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21061996
更新日期:2020-03-14 00:00:00
abstract::The present study was performed to investigate the effects of chronic administration of nonylphenol (NP) on the expression of inflammation-related genes in the brains of mice. NP was given orally by gavages at 0, 50, 100, and 200 mg/kg/d. The expression of inflammatory enzymes, inducible nitric oxide synthase (iNOS) a...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms9101977
更新日期:2008-10-01 00:00:00
abstract::The aim of the experiment was to evaluate the effect of preconditioning based on changes in inspiratory oxygen fraction on endothelial function in the model of ischemia-reperfusion injury of the myocardium in the condition of cardiopulmonary bypass. The prospective randomized study included 32 rabbits divided into fou...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21155336
更新日期:2020-07-27 00:00:00
abstract::The importance of zinc for male fertility only emerged recently, being propelled in part by consumer interest in nutritional supplements containing ionic trace minerals. Here, we review the properties, biological roles and cellular mechanisms that are relevant to zinc function in the male reproductive system, survey a...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19124097
更新日期:2018-12-18 00:00:00
abstract:BACKGROUND:Dp71 is the most abundant dystrophin (DMD) gene product in the nervous system. Mutation in the Dp71 coding region is associated with cognitive disturbances in Duchenne muscular dystrophy (DMD) patients, but the function of dystrophin Dp71 in tumor progression remains to be established. This study investigate...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20215429
更新日期:2019-10-31 00:00:00
abstract::Stress-associated proteins (SAPs) are novel A20/AN1 zinc finger domain-containing proteins that are now favorable targets to improve abiotic stress tolerance in plants. However, the SAP gene family and their biological functions have not been identified in the important fruit crop apple (Malus × domestica Borkh.). We ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19092478
更新日期:2018-08-21 00:00:00
abstract::The global spread of bacterial resistance to antibiotics promotes a search for alternative approaches to eradication of pathogenic bacteria. One alternative is using photosensitizers for inhibition of Gram-positive and Gram-negative bacteria under illumination. Due to low penetration of visible light into tissues, app...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20133196
更新日期:2019-06-29 00:00:00
abstract::Extracellular matrix protein turnover may play an important role in left atrial (LA) remodelling. The aim is to investigate the associations between matrix metalloproteinase (MMPs), tissue inhibitor of metalloproteinase (TIMP-1) and LA volume index (LAVI) and if these associations are independent of TIMP-1 levels. Par...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21144944
更新日期:2020-07-13 00:00:00
abstract::C-type lectin receptors and their adaptor molecules are involved in the recognition of glycosylated self-antigens and pathogens. However, little is known about the species- and organ-specific expression profiles of these molecules. We therefore determined the mRNA expression levels of Dectin-1, MR1, MR2, DC-SIGN, Syk,...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms130810113
更新日期:2012-01-01 00:00:00
abstract::Recently, we used a recombinant produced C-terminus (D194-F319) of the Clostridium perfringens enterotoxin (C-CPE) to functionalize gold nanoparticles (AuNPs) for a subsequent specific killing of claudin expressing tumor cells using the gold nanoparticle-mediated laser perforation (GNOME-LP) technique. For a future in...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20174248
更新日期:2019-08-30 00:00:00
abstract::Our laboratory and others previously showed that Annexin A2 knockout (A2KO) mice had impaired blood-brain barrier (BBB) development and elevated pro-inflammatory response in macrophages, implying that Annexin A2 (AnxA2) might be one of the key endogenous factors for maintaining homeostasis of the neurovascular unit in...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20246125
更新日期:2019-12-05 00:00:00
abstract::Osteoarthritis (OA) remains one of the common degenerative joint diseases and a major cause of pain and disability in older adult individuals. Oral administration of non-steroidal anti-inflammatory drugs (NSAIDs) (such as diclofenac, DIC) or intra-articular injected gluco-corticosteroids (such as dexamethasone, DEX) w...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22020665
更新日期:2021-01-11 00:00:00
abstract::Variegated plants are valuable materials for investigating leaf color regulated mechanisms. To unveil the role of posttranslational modification in the variegated phenotype, we conducted global quantitative phosphoproteomic analysis on different leaf color sectors of Maiyuanjinqiu and the corresponding of Catalpa farg...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20081895
更新日期:2019-04-17 00:00:00
abstract::Nanoscience and nanotechnology shows immense interest in various areas of research and applications, including biotechnology, biomedical sciences, nanomedicine, and veterinary medicine. Studies and application of nanotechnology was explored very extensively in the human medical field and also studies undertaken in rod...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19113299
更新日期:2018-10-24 00:00:00
abstract::In the absence of visible mucosal damage, it is hypothesized that the esophageal mucosal barrier is functionally impaired in patients with non-erosive reflux disease (NERD). The aim of the present study was to perform an exploratory analysis of the mucosal barrier in NERD compared to erosive esophagitis (EE) and contr...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18051091
更新日期:2017-05-19 00:00:00
abstract::Plant phenolics have been for many years a theme of major scientific and applied interest. Grape berry phenolics contribute to organoleptic properties, color and protection against environmental challenges. Climate change has already caused significant warming in most grape-growing areas of the world, and the climatic...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms140918711
更新日期:2013-09-11 00:00:00
abstract::Alzheimer's disease (AD) is the leading cause of dementia worldwide. It involves progressive impairment of cognitive function. A growing number of neuroprotective compounds have been identified with potential anti-AD properties through in vitro and in vivo models of AD. Quercetin, a natural flavonoid contained in a wi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21020493
更新日期:2020-01-13 00:00:00
abstract::Sunflower (Helianthus annuus L.) oil remains under-utilised albeit one of the major seed oils produced world-wide. Moreover, the high oleic sunflower varieties make the oil attractive for applications requiring high temperature processes and those targeting the C=C double bond functionality. Herein an overview of the ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms9081393
更新日期:2008-08-01 00:00:00
abstract::Acute lung injury (ALI) is a life-threatening syndrome characterized by acute and severe hypoxemic respiratory failure. Visfatin, which is known as an obesity-related cytokine with pro-inflammatory activities, plays a role in regulation of inflammatory cytokines. The mechanisms of ALI remain unclear in critically ill ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20071678
更新日期:2019-04-04 00:00:00
abstract:BACKGROUND:We determined relationships of cholesterol efflux capacity (CEC), plasma cholesterol esterification (EST) and cholesteryl ester transfer (CET) with anti-c-terminus apoA-1 (Ac-terAA1) and anti-apolipoprotein (apo)-1 (AAA1) autoantibodies in subjects with and without Type 2 diabetes mellitus (T2D). METHODS:In...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20030732
更新日期:2019-02-09 00:00:00
abstract::The pathogenesis of type 2 diabetes (T2D) involves chronic hyperinsulinemia due to systemic and hepatic insulin resistance (IR), which if uncorrected, will lead to progressive pancreatic beta cell failure in predisposed individuals. Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of fatty (simple stea...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms17030355
更新日期:2016-03-09 00:00:00
abstract::Growth hormone (GH), mostly through its peripheral mediator, the insulin-like growth factor 1(IGF1), in addition to carrying out its fundamental action to promote linear bone growth, plays an important role throughout life in the regulation of intermediate metabolism, trophism and function of various organs, especiall...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21041392
更新日期:2020-02-19 00:00:00
abstract::Pinellia ternata is an important traditional Chinese medicinal plant. The growth of P. ternata is sensitive to high temperatures. To gain a better understanding of heat stress responses in P. ternata, we performed a comparative proteomic analysis. P. ternata seedlings were subjected to a temperature of 38 °C and sampl...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms141020614
更新日期:2013-10-15 00:00:00
abstract::Long noncoding RNA (lncRNA), circular RNA (circRNA), and microRNA (miRNA) are important in the regulation of life activities. However, their function is unclear in Paulownia fortunei. To identify lncRNAs, circRNAs, and miRNA, and investigate their roles in the infection progress of Paulownia witches' broom (PaWB) dise...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19082463
更新日期:2018-08-20 00:00:00
abstract::To investigate Fe deficiency tolerance in tomato cultivars, quantification of proteins and genes involved in Fe metabolism and antioxidant mechanisms were performed in "Roggusanmaru" and "Super Doterang". Fe deficiency (Moderate, low and -Fe) significantly decreased the biomass, total, and apoplastic Fe concentration ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms161226086
更新日期:2015-11-25 00:00:00
abstract::Bioelectrochemical systems (BES) are groups of bioelectrochemical technologies and platforms that could facilitate versatile environmental and biological applications. The performance of BES is mainly determined by the key process of electron transfer at the bacteria and electrode interface, which is known as extracel...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18010090
更新日期:2017-01-04 00:00:00
abstract::Peritoneal dialysis effluent (PDE) potentially carries an archive of peptides relevant to pathological processes in abdominal and surrounding tissues. Magnetic beads and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry is one such approach that offers a unique tool for profiling of peptides...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15011162
更新日期:2014-01-16 00:00:00