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Carnosine as a Possible Drug for Zinc-Induced Neurotoxicity and Vascular Dementia.

Abstract：

:Increasing evidence suggests that the metal homeostasis is involved in the pathogenesis of various neurodegenerative diseases including senile type of dementia such as Alzheimer's disease, dementia with Lewy bodies, and vascular dementia. In particular, synaptic Zn2+ is known to play critical roles in the pathogenesis of vascular dementia. In this article, we review the molecular pathways of Zn2+-induced neurotoxicity based on our and numerous other findings, and demonstrated the implications of the energy production pathway, the disruption of calcium homeostasis, the production of reactive oxygen species (ROS), the endoplasmic reticulum (ER)-stress pathway, and the stress-activated protein kinases/c-Jun amino-terminal kinases (SAPK/JNK) pathway. Furthermore, we have searched for substances that protect neurons from Zn2+-induced neurotoxicity among various agricultural products and determined carnosine (β-alanyl histidine) as a possible therapeutic agent for vascular dementia.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Kawahara M,Sadakane Y,Mizuno K,Kato-Negishi M,Tanaka KI

doi

10.3390/ijms21072570

subject

Has Abstract

pub_date

2020-04-07 00:00:00

issue

7

issn

1422-0067

pii

ijms21072570

journal_volume

21

pub_type

杂志文章,评审

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