Abstract：
:Growth hormone (GH), mostly through its peripheral mediator, the insulin-like growth factor 1(IGF1), in addition to carrying out its fundamental action to promote linear bone growth, plays an important role throughout life in the regulation of intermediate metabolism, trophism and function of various organs, especially the cardiovascular, muscular and skeletal systems. Therefore, if a prepubertal GH secretory deficiency (GHD) is responsible for short stature, then a deficiency in adulthood identifies a nosographic picture classified as adult GHD syndrome, which is characterized by heart, muscle, bone, metabolic and psychic abnormalities. A GHD may occur in patients with pituitary autoimmunity; moreover, GHD may also be one of the features of some genetic syndromes in association with other neurological, somatic and immune alterations. This review will discuss the impact of pituitary autoimmunity on GHD and the occurrence of GHD in the context of some genetic disorders. Moreover, we will discuss some genetic alterations that cause GH and IGF-1 insensitivity and the arguments in favor and against the influence of GH/IGF-1 on longevity and cancer in the light of the papers on these issues that so far appear in the literature.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Bellastella G,Maiorino MI,Longo M,Cirillo P,Scappaticcio L,Vietri MT,Bellastella A,Esposito K,De Bellis Adoi
10.3390/ijms21041392subject
Has Abstractpub_date
2020-02-19 00:00:00issue
4issn
1422-0067pii
ijms21041392journal_volume
21pub_type
杂志文章,评审abstract：:Sabicea species are used in the Amazon for treatment of fever and malaria, which suggests that its chemical constituents may have some effect on pain and inflammation. Phytochemical analysis of the hexane fraction obtained from the crude ethanol extract from Sabicea grisea var. grisea Cham. & Schltdl (Rubiaceae), an e...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13021598
更新日期：2012-01-01 00:00:00
abstract：:Two new ergostane-type sterols; (22E)-5α,6α-epoxyergosta-8,14,22-triene-3β,7β-diol (1) and 5α,6α-epoxyergost-8(14)-ene-3β,7α-diol (2) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with eight known compounds (3-10). All isolated compounds were evaluated for their inhibitory ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18112479
更新日期：2017-11-21 00:00:00
abstract：:Intravenous iron preparations are typically classified as non-dextran-based or dextran/dextran-based complexes. The carbohydrate shell for each of these preparations is unique and is key in determining the various physicochemical properties, the metabolic pathway, and the immunogenicity of the iron-carbohydrate comple...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17071185
更新日期：2016-07-21 00:00:00
abstract：:Photodynamic therapy (PDT) is a cancer treatment modality that requires three components, namely light, dioxygen and a photosensitizing agent. After light excitation, the photosensitizer (PS) in its excited state transfers its energy to oxygen, which leads to photooxidation reactions. In order to improve the selectivi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161024059
更新日期：2015-10-12 00:00:00
abstract：:The domestic ferret (Mustela putorius furo) is an important model organism for the study of avian influenza and other diseases of humans and animals, as well as a popular pet animal. In order to evaluate genetic diversity and study disease relationships in ferrets, 22 nuclear microsatellite loci (17 dinucleotide and 5...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms131216592
更新日期：2012-12-05 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2012-12-24 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15045874
更新日期：2014-04-08 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 社论
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更新日期：2019-04-08 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20122972
更新日期：2019-06-18 00:00:00
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pub_type： 杂志文章,撤回出版物
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更新日期：2016-05-20 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2021-01-15 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18091862
更新日期：2017-08-28 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21144841
更新日期：2020-07-08 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19092532
更新日期：2018-08-27 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071719
更新日期：2019-04-06 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20174080
更新日期：2019-08-21 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19124097
更新日期：2018-12-18 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21082659
更新日期：2020-04-11 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2016-01-21 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18071533
更新日期：2017-07-15 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-10-24 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-08-09 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2017-05-09 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19051390
更新日期：2018-05-07 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19102984
更新日期：2018-09-30 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249629
更新日期：2020-12-17 00:00:00
abstract：:Hormonal dynamics after Plasmodiophora brassicae infection were compared in two Brassica napus cultivars-more resistant SY Alister and more sensitive Hornet, in order to elucidate responses associated with efficient defense. Both cultivars responded to infection by the early transient elevation of active cytokinins (p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19124024
更新日期：2018-12-13 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 临床试验,杂志文章
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更新日期：2019-09-23 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2018-08-06 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140714185
更新日期：2013-07-09 00:00:00
