Abstract：
:Marek's Disease (MD) is a highly contagious pathogenic and oncogenic disease primarily affecting chickens. Chicken Lines 63 and 72, as well as their recombinant congenic strains (RCS) with varied susceptibility to MD, are ideal models to study the complex mechanisms of genetic resistance to MD. In this study, we investigated copy number variation (CNV) in these inbred chicken lines using the Affymetrix Axiom HD 600 K SNP genotyping array. We detected 393 CNV segments across all ten chicken lines, of which 12 CNVs were specifically identified in Line 72. We then assessed genetic structure based on CNV and observed markedly different patterns. Finally, we validated two deletion events in Line 72 and correlated them with genes expression using qPCR and RNA-seq, respectively. Our combined results indicated that these two CNV deletions were likely to contribute to MD susceptibility.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Xu L,He Y,Ding Y,Sun G,Carrillo JA,Li Y,Ghaly MM,Ma L,Zhang H,Liu GE,Song Jdoi
10.3390/ijms18051020subject
Has Abstractpub_date
2017-05-09 00:00:00issue
5issn
1422-0067pii
ijms18051020journal_volume
18pub_type
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