Characterization of Copy Number Variation's Potential Role in Marek's Disease.


:Marek's Disease (MD) is a highly contagious pathogenic and oncogenic disease primarily affecting chickens. Chicken Lines 63 and 72, as well as their recombinant congenic strains (RCS) with varied susceptibility to MD, are ideal models to study the complex mechanisms of genetic resistance to MD. In this study, we investigated copy number variation (CNV) in these inbred chicken lines using the Affymetrix Axiom HD 600 K SNP genotyping array. We detected 393 CNV segments across all ten chicken lines, of which 12 CNVs were specifically identified in Line 72. We then assessed genetic structure based on CNV and observed markedly different patterns. Finally, we validated two deletion events in Line 72 and correlated them with genes expression using qPCR and RNA-seq, respectively. Our combined results indicated that these two CNV deletions were likely to contribute to MD susceptibility.


Int J Mol Sci


Xu L,He Y,Ding Y,Sun G,Carrillo JA,Li Y,Ghaly MM,Ma L,Zhang H,Liu GE,Song J




Has Abstract


2017-05-09 00:00:00










  • Advances and Future Applications of Augmented Peripheral Nerve Regeneration.

    abstract::Peripheral nerve injuries remain a significant source of long lasting morbidity, disability, and economic costs. Much research continues to be performed in areas related to improving the surgical outcomes of peripheral nerve repair. In this review, the physiology of peripheral nerve regeneration and the multitude of e...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Jones S,Eisenberg HM,Jia X

    更新日期:2016-09-07 00:00:00

  • The Novel Roles of Connexin Channels and Tunneling Nanotubes in Cancer Pathogenesis.

    abstract::Neoplastic growth and cellular differentiation are critical hallmarks of tumor development. It is well established that cell-to-cell communication between tumor cells and "normal" surrounding cells regulates tumor differentiation and proliferation, aggressiveness, and resistance to treatment. Nevertheless, the mechani...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Valdebenito S,Lou E,Baldoni J,Okafo G,Eugenin E

    更新日期:2018-04-24 00:00:00

  • Melatonin-Mediated Regulation of Growth and Antioxidant Capacity in Salt-Tolerant Naked Oat under Salt Stress.

    abstract::Melatonin (MT; N-acetyl-5-methoxytryptamine) is a pleiotropic signaling molecule that has been demonstrated to play an important role in plant growth, development, and regulation of environmental stress responses. Studies have been conducted on the role of the exogenous application of MT in a few species, but the pote...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Gao W,Feng Z,Bai Q,He J,Wang Y

    更新日期:2019-03-07 00:00:00

  • Gadolinium Chloride Restores the Function of the Gap Junctional Intercellular Communication between Hepatocytes in a Liver Injury.

    abstract:BACKGROUND:Gadolinium chloride (GdCl3) has been reported to attenuate liver injury caused by a variety of toxicants. Gap junctional intercellular communication (GJIC) is thought to be essential in controlling liver homeostasis and pathology. Here we evaluate the effects of GdCl3 on functional GJIC and connexin expressi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Yang L,Dong C,Tian L,Ji X,Yang L,Li L

    更新日期:2019-07-31 00:00:00

  • Histone H1 Post-Translational Modifications: Update and Future Perspectives.

    abstract::Histone H1 is the most variable histone and its role at the epigenetic level is less characterized than that of core histones. In vertebrates, H1 is a multigene family, which can encode up to 11 subtypes. The H1 subtype composition is different among cell types during the cell cycle and differentiation. Mass spectrome...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Andrés M,García-Gomis D,Ponte I,Suau P,Roque A

    更新日期:2020-08-18 00:00:00

  • Metabolomics and Transcriptomics Identify Multiple Downstream Targets of Paraburkholderia phymatum σ54 During Symbiosis with Phaseolus vulgaris.

    abstract::RpoN (or σ54) is the key sigma factor for the regulation of transcription of nitrogen fixation genes in diazotrophic bacteria, which include α- and β-rhizobia. Our previous studies showed that an rpoN mutant of the β-rhizobial strain Paraburkholderia phymatum STM815T formed root nodules on Phaseolus vulgaris cv. Negro...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lardi M,Liu Y,Giudice G,Ahrens CH,Zamboni N,Pessi G

    更新日期:2018-04-01 00:00:00

  • Stability Profiles and Therapeutic Effect of Cu/Zn Superoxide Dismutase Chemically Coupled to O-Quaternary Chitosan Derivatives against Dextran Sodium Sulfate-Induced Colitis.

    abstract::Superoxide dismutase (SOD) has attracted considerable attention on treatment of reactive oxygen species (ROS)-related disorders. We previously conjugated Cu/Zn SOD to O-quaternary chitosan derivatives (O-HTCC) to yield a polymer-enzyme conjugate O-HTCC-SOD that demonstrated superior therapeutic effect to native SOD. T...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhao N,Feng Z,Shao M,Cao J,Wang F,Liu C

    更新日期:2017-05-24 00:00:00

  • Determination of Sphingosine-1-Phosphate in Human Plasma Using Liquid Chromatography Coupled with Q-Tof Mass Spectrometry.

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Egom EE,Fitzgerald R,Canning R,Pharithi RB,Murphy C,Maher V

    更新日期:2017-08-18 00:00:00

  • SwarmDock and the use of normal modes in protein-protein docking.

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Moal IH,Bates PA

    更新日期:2010-09-28 00:00:00

  • Melatonin Deficiency Confers Tolerance to Multiple Abiotic Stresses in Rice via Decreased Brassinosteroid Levels.

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Hwang OJ,Back K

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Gaur M,Dobke M,Lunyak VV

    更新日期:2017-01-20 00:00:00

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhao Q,Coughlan KA,Zou MH,Song P

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  • An Overview of ADAM9: Structure, Activation, and Regulation in Human Diseases.

    abstract::ADAM9 (A disintegrin and a metalloprotease 9) is a membrane-anchored protein that participates in a variety of physiological functions, primarily through the disintegrin domain for adhesion and the metalloprotease domain for ectodomain shedding of a wide variety of cell surface proteins. ADAM9 influences the developme...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Chou CW,Huang YK,Kuo TT,Liu JP,Sher YP

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  • Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson's Disease.

    abstract::The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation, and life span. mTOR signaling is a central regulator of autophagy by modulating multiple aspects of the autophagy process, such as initiation, process, and termination through controlling the acti...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Zhu Z,Yang C,Iyaswamy A,Krishnamoorthi S,Sreenivasmurthy SG,Liu J,Wang Z,Tong BC,Song J,Lu J,Cheung KH,Li M

    更新日期:2019-02-08 00:00:00

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


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  • Cell Fitness: More Than Push-Ups.

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


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  • Autocrine TGF-β in Cancer: Review of the Literature and Caveats in Experimental Analysis.

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Ungefroren H

    更新日期:2021-01-19 00:00:00

  • Levels of Interleukin-6 in Saliva, but Not Plasma, Correlate with Clinical Metrics in Huntington's Disease Patients and Healthy Control Subjects.

    abstract::Growing evidence suggests that inflammatory responses, in both the brain and peripheral tissues, contribute to disease pathology in Huntington's disease (HD), an inherited, progressive neurodegenerative disorder typically affecting adults in their 30-40 s. Hence, studies of inflammation-related markers in peripheral f...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Corey-Bloom J,Fischer RS,Kim A,Snell C,Parkin GM,Granger DA,Granger SW,Thomas EA

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  • Effects of Selective Substitution of Cysteine Residues on the Conformational Properties of Chlorotoxin Explored by Molecular Dynamics Simulations.

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Gregory AJ,Voit-Ostricki L,Lovas S,Watts CR

    更新日期:2019-03-13 00:00:00

  • Critical Overview of the Risk Scoring Systems to Predict Non-Responsiveness to Intravenous Immunoglobulin in Kawasaki Syndrome.

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Rigante D,Andreozzi L,Fastiggi M,Bracci B,Natale MF,Esposito S

    更新日期:2016-02-24 00:00:00

  • Regulation of Connexin Gap Junctions and Hemichannels by Calcium and Calcium Binding Protein Calmodulin.

    abstract::Connexins are the structural components of gap junctions and hemichannels that mediate the communication and exchange of small molecules between cells, and between the intracellular and extracellular environment, respectively. Connexin (Cx) 46 is predominately expressed in lens fiber cells, where they function in main...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Hu Z,Riquelme MA,Gu S,Jiang JX

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  • Resveratrol and Its Effects on the Vascular System.

    abstract::Resveratrol, the phenolic substance isolated initially from Veratrum grandiflorum and richly present in grapes, wine, peanuts, soy, and berries, has been attracting attention of scientists and medical doctors for many decades. Herein, we review its effects on the vascular system. Studies utilizing cell cultures and pr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Breuss JM,Atanasov AG,Uhrin P

    更新日期:2019-03-27 00:00:00

  • The Effects of Cobalt Protoporphyrin IX and Tricarbonyldichlororuthenium (II) Dimer Treatments and Its Interaction with Nitric Oxide in the Locus Coeruleus of Mice with Peripheral Inflammation.

    abstract::Heme oxygenase 1 (HO-1) and carbon monoxide were shown to normalize oxidative stress and inflammatory reactions induced by neuropathic pain in the central nervous system, but their effects in the locus coeruleus (LC) of animals with peripheral inflammation and their interaction with nitric oxide are unknown. In wild-t...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Moreno P,Cazuza RA,Mendes-Gomes J,Díaz AF,Polo S,Leánez S,Leite-Panissi CRA,Pol O

    更新日期:2019-05-05 00:00:00

  • ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1.

    abstract::Acetylation of nuclear apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is associated with its extracellular secretion, despite the lack of an N-terminal protein secretion signal. In this study, we investigated plasma membrane targeting and translocation of APE1/Ref-1 in HEK293T cells with enhanced ace...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lee YR,Joo HK,Lee EO,Cho HS,Choi S,Kim CS,Jeon BH

    更新日期:2019-06-28 00:00:00

  • Antibacterial Activity of Juglone against Staphylococcus aureus: From Apparent to Proteomic.

    abstract::The proportion of foodborne disease caused by pathogenic microorganisms is rising worldwide, with staphylococcal food poisoning being one of the main causes of this increase. Juglone is a plant-derived 1,4-naphthoquinone with confirmed antibacterial and antitumor activities. However, the specific mechanism underlying ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wang J,Cheng Y,Wu R,Jiang D,Bai B,Tan D,Yan T,Sun X,Zhang Q,Wu Z

    更新日期:2016-06-18 00:00:00

  • Inhibition of oxidative stress by low-molecular-weight polysaccharides with various functional groups in skin fibroblasts.

    abstract::The aim of this study was to evaluate the in cellulo inhibition of hydrogen-peroxide-induced oxidative stress in skin fibroblasts using different low-molecular-weight polysaccharides (LMPS) prepared from agar (LMAG), chitosan (LMCH) and starch (LMST), which contain various different functional groups (i.e., sulfate, a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Chen SK,Hsu CH,Tsai ML,Chen RH,Drummen GP

    更新日期:2013-09-25 00:00:00

  • Prediction of a new ligand-binding site for type 2 motif based on the crystal structure of ALG-2 by dry and wet approaches.

    abstract::ALG-2 is a penta-EF-hand Ca(2+)-binding protein and interacts with a variety of intracellular proteins. Two types of ALG-2-binding motifs have been determined: type 1, PXYPXnYP (X, variable; n = 4), in ALIX and PLSCR3; type 2, PXPGF, in Sec31A and PLSCR3. The previously solved X-ray crystal structure of the complex be...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Takahashi T,Suzuki H,Inuzuka T,Shibata H,Maki M

    更新日期:2012-01-01 00:00:00

  • Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies.

    abstract::The treatment of cancer has been slowly but steadily progressing during the last fifty years. Some tumors with a high mortality in the past are curable nowadays. However, there is one striking exception: glioblastoma multiforme. No real breakthrough has been hitherto achieved with this tumor with ominous prognosis and...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Harguindey S,Polo Orozco J,Alfarouk KO,Devesa J

    更新日期:2019-09-01 00:00:00

  • The Impact of the 'Mis-Peptidome' on HLA Class I-Mediated Diseases: Contribution of ERAP1 and ERAP2 and Effects on the Immune Response.

    abstract::The strong association with the Major Histocompatibility Complex (MHC) class I genes represents a shared trait for a group of autoimmune/autoinflammatory disorders having in common immunopathogenetic basis as well as clinical features. Accordingly, the main risk factors for Ankylosing Spondylitis (AS), prototype of th...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Tedeschi V,Paldino G,Paladini F,Mattorre B,Tuosto L,Sorrentino R,Fiorillo MT

    更新日期:2020-12-17 00:00:00

  • Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation.

    abstract::A key role of the mitochondrial Translocator Protein 18 KDa (TSPO) in neuroinflammation has been recently proposed. However, little is known about TSPO-activated pathways underlying the modulation of reactive microglia. In the present work, the TSPO activation was explored in an in vitro human primary microglia model ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Pozzo ED,Tremolanti C,Costa B,Giacomelli C,Milenkovic VM,Bader S,Wetzel CH,Rupprecht R,Taliani S,Settimo FD,Martini C

    更新日期:2019-09-10 00:00:00