Abstract：
:The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are involved in myriad cellular processes. Their distribution in various cellular compartments underlines their essential roles in cellular homeostasis. HSP90 and its co-chaperones orchestrate crucial physiological processes such as cell survival, cell cycle control, hormone signaling, and apoptosis. Conversely, HSP90, and its secreted forms, contribute to the development and progress of serious pathologies, including cancer and neurodegenerative diseases. Therefore, targeting HSP90 is an attractive strategy for the treatment of neoplasms and other diseases. This manuscript will review the general structure, regulation and function of HSP90 family and their potential role in pathophysiology.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Hoter A,El-Sabban ME,Naim HYdoi
10.3390/ijms19092560subject
Has Abstractpub_date
2018-08-29 00:00:00issue
9issn
1422-0067pii
ijms19092560journal_volume
19pub_type
杂志文章,评审abstract：:Tissue engineering is an emerging field of research which combines the use of cell-seeded biomaterials both in vitro and/or in vivo with the aim of promoting new tissue formation or regeneration. In this context, how cells colonize and interact with the biomaterial is critical in order to get a functional tissue engin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms12118217
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21020578
更新日期：2020-01-16 00:00:00
abstract：:Krüppel-like factor 4 (Klf4) plays an important role in the transition from proliferation to differentiation in a wide variety of cells. Previous studies demonstrated its critical role in the luteal transition of preovulatory granulosa cells (GCs). This study used cultured rat preovulatory GCs to investigate the mecha...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-10-06 00:00:00
abstract：:Despite improvements in diagnosis and treatment, breast cancer is still the most common cancer type among non-smoking females. TGF-β can inhibit breast cancer development by inducing cell cycle arrest in both, cancer cells and, as part of a senescence program in normal human mammary epithelial cells (HMEC). Moreover, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18071574
更新日期：2017-07-20 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2014-07-29 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 社论
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更新日期：2020-06-22 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-02-12 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-11-06 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-12-17 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-11-28 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19123855
更新日期：2018-12-03 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20040837
更新日期：2019-02-15 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-01-13 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18040170
更新日期：2017-03-23 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160921606
更新日期：2015-09-08 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-04-15 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2016-03-04 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2016-07-28 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,meta分析,评审
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更新日期：2018-09-20 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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journal_title：International journal of molecular sciences
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更新日期：2013-12-11 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2010-04-15 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-02-26 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2014-12-03 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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journal_title：International journal of molecular sciences
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更新日期：2020-05-08 00:00:00
abstract：:Hyperpolarization-activated cationic HCN channels comprise four members (HCN1-4) that control dendritic integration, synaptic transmission and action potential firing. In the kidney, HCN1, HCN2 and HCN3 are differentially expressed and contribute to the transport of sodium, potassium (K+) and ammonium into the nephron...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20204995
更新日期：2019-10-09 00:00:00
