Abstract：
:This study aimed to examine whether inhibition of hexokinase (HK)-II activity enhances the efficacy of sorafenib in in-vivo models of hepatocellular carcinoma (HCC), and to evaluate the prognostic implication of HK-II expression in patients with HCC. We used 3-bromopyruvate (3-BP), a HK-II inhibitor to target HK-II. The human HCC cell line was tested as both subcutaneous and orthotopic tumor xenograft models in BALB/c nu/nu mice. The prognostic role of HK-II was evaluated in data from HCC patients in The Cancer Genome Atlas (TCGA) database and validated in patients treated with sorafenib. Quantitative real-time PCR, western blot analysis, and immunohistochemical staining revealed that HK-II expression is upregulated in the presence of sorafenib. Further analysis of the endoplasmic reticulum-stress network model in two different murine HCC models showed that the introduction of additional stress by 3-BP treatment synergistically increased the in vivo/vitro efficacy of sorafenib. We found that HCC patients with increased HK-II expression in the TCGA database showed poor overall survival, and also confirmed similar results for TCGA database HCC patients who had undergone sorafenib treatment. These results suggest that HK-II is a promising therapeutic target to enhance the efficacy of sorafenib and that HK-II expression might be a prognostic factor in HCC.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Yoo JJ,Yu SJ,Na J,Kim K,Cho YY,Lee YB,Cho EJ,Lee JH,Kim YJ,Youn H,Yoon JHdoi
10.3390/ijms20061292subject
Has Abstractpub_date
2019-03-14 00:00:00issue
6issn
1422-0067pii
ijms20061292journal_volume
20pub_type
杂志文章abstract：:Ionic liquids (ILs), entirely composed of cations and anions, are liquid solvents at room temperature. They are interesting due to their low vapor pressure, high polarity and thermostability, and also for the possibility to fine-tune their physicochemical properties through modification of the chemical structures of t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms150712196
更新日期：2014-07-09 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19010120
更新日期：2018-01-02 00:00:00
abstract：:Due to a typesetting error during layout, several references were incorrectly listed in [...]. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,已发布勘误
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更新日期：2019-05-29 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2008-09-01 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-01-22 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2017-05-06 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-11-08 00:00:00
abstract：:Experiments were carried out to investigate the effects of various factors on the activity and conformation of recombinant leucine aminopeptidase of Bacillus kaustophilus CCRC 11223 (BkLAP) and potential utilization of BkLAP in the hydrolysis of anchovy protein. Optimal temperature and pH of BkLAP were 70 °C and 8.0 i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12117609
更新日期：2011-01-01 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms16035254
更新日期：2015-03-06 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21103481
更新日期：2020-05-14 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20061375
更新日期：2019-03-19 00:00:00
abstract：:Drought is one of the major environmental factors limiting biomass and seed yield production in agriculture. In this research, we focused on plants from the Fabaceae family, which has a unique ability for the establishment of symbiosis with nitrogen-fixing bacteria, and are relatively susceptible to water limitation. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051204
更新日期：2019-03-09 00:00:00
abstract：:Epidemiological studies on workers employed at the Mayak plutonium enrichment plant have demonstrated an association between external gamma ray exposure and an elevated risk of ischemic heart disease (IHD). In a previous study using fresh-frozen post mortem samples of the cardiac left ventricle of Mayak workers and no...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21186832
更新日期：2020-09-17 00:00:00
abstract：:Glioblastoma (GBM) is an extremely aggressive tumor of the central nervous system, with a prognosis of 12-15 months and just 3-5% of survival over 5 years. This is mainly because most patients suffer recurrence after treatment that currently consists in maximal resection followed by radio- and chemotherapy with temozo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-06-04 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2018-12-14 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-08-27 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082233
更新日期：2018-07-31 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-12-30 00:00:00
abstract：:Sex reversal has been used as a breeding strategy by salmonid fish to produce genetically and phenotypically single sex populations. Production of all-female fish has great importance for the creation of monosex female triploids of salmonid fish, which are valued for their sterility, lack of female maturation, and lar...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2021-01-19 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2017-09-12 00:00:00
abstract：:In the present work, we investigated the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the monophenolase and diphenolase activity of mushroom tyrosinase. The results showed that diflunisal and indomethacin inhibited both monophenolase and diphenolase activity. For monophenolase activity, the lag time was...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12063998
更新日期：2011-01-01 00:00:00
abstract：:Sulfur (S) is an essential element for all forms of life. It is involved in numerous essential processes because S is considered as the primary source of one of the essential amino acids, methionine, which plays an important role in biological events. For the control and regulation of sulfate in a metabolic network th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-04-07 00:00:00
abstract：:Cardiovascular disease is the leading cause of morbidity and mortality in the Western and developing world, and the incidence of cardiovascular disease is increasing with the longer lifespan afforded by our modern lifestyle. Vascular diseases including coronary heart disease, high blood pressure, and stroke comprise t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-06-25 00:00:00
abstract：:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most frequent human enzymopathy, affecting over 400 million people globally. Worldwide, 217 mutations have been reported at the genetic level, and only 19 have been found in Mexico. The objective of this work was to contribute to the knowledge of the function ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-04-15 00:00:00
abstract：:Transforming growth factor beta (TGF-β) proteins are multifunctional cytokines whose neural functions are increasingly recognized. The machinery of TGF-β signaling, including the serine kinase type transmembrane receptors, is present in the central nervous system. However, the 3 mammalian TGF-β subtypes have distinct ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13078219
更新日期：2012-01-01 00:00:00
