Abstract：
:The oleoresin of Copaifera trees has been widely used as a traditional medicine in Neotropical regions for thousands of years and remains a popular treatment for a variety of ailments. The copaiba resins are generally composed of a volatile oil made up largely of sesquiterpene hydrocarbons, such as β-caryophyllene, α-copaene, β-elemene, α-humulene, and germacrene D. In addition, the oleoresin is also made up of several biologically active diterpene acids, including copalic acid, kaurenoic acid, alepterolic acid, and polyalthic acid. This review presents a summary of the ecology and distribution of Copaifera species, the traditional uses, the biological activities, and the phytochemistry of copaiba oleoresins. In addition, several biomolecular targets relevant to the bioactivities have been implicated by molecular docking methods.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
da Trindade R,da Silva JK,Setzer WNdoi
10.3390/ijms19051511subject
Has Abstractpub_date
2018-05-18 00:00:00issue
5issn
1422-0067pii
ijms19051511journal_volume
19pub_type
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