New Innovations in Wound Healing and Repair.

abstract：BACKGROUND:It is well known that diabetes mellitus impairs immunity and therefore is an independent risk factor for tuberculosis. However, the influence of associated metabolic factors, such as hypertension, dyslipidemia and gout has yet to be confirmed. This study aimed to investigate whether the strong association be...

journal_title：International journal of molecular sciences

authors： Lee MY,Lin KD,Hsu WH,Chang HL,Yang YH,Hsiao PJ,Shin SJ

更新日期：2015-05-18 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) causes hemorrhagic colitis and hemolytic uremic syndrome. EHEC infection begins with bacterial adherence to the host intestine via lectin-like adhesins that bind to the intestinal wall. However, EHEC-related lectin-glycan interactions (LGIs) remain unknown. Here, we conducted ...

journal_title：International journal of molecular sciences

authors： Cho SH,Lee KM,Kim CH,Kim SS

更新日期：2020-04-12 00:00:00

abstract：:In the endoplasmic reticulum (ER), misfolded and unfolded proteins are eliminated by a process called ER-associated protein degradation (ERAD) in order to maintain cell homeostasis. In the ERAD pathway, several ER-localized E3 ubiquitin ligases target ERAD substrate proteins for ubiquitination and subsequent proteasom...

journal_title：International journal of molecular sciences

authors： Harada K,Kato M,Nakamura N

更新日期：2016-11-02 00:00:00

abstract：:In this study, we systematically investigated the process of sex reversal induced by 17-methyltestosterone (MT) feeding and MT-feeding withdrawal at the ovary differentiation stage in orange-spotted groupers, Epinephelus coioides. Gonadal histology showed that MT feeding induced a precocious sex reversal from immature...

journal_title：International journal of molecular sciences

authors： Wang Q,Huang M,Peng C,Wang X,Xiao L,Wang D,Chen J,Zhao H,Zhang H,Li S,Yang H,Liu Y,Lin H,Zhang Y

更新日期：2018-09-19 00:00:00

abstract：:Extracellular vesicles (EVs) are membrane-bound particles involved in intercellular communication. They carry proteins, lipids, and nucleotides such as microRNAs (miRNAs) from the secreting cell that can modulate target cells. We and others have previously described the presence of EVs in peripheral blood of multiple ...

journal_title：International journal of molecular sciences

authors： Sáenz-Cuesta M,Alberro A,Muñoz-Culla M,Osorio-Querejeta I,Fernandez-Mercado M,Lopetegui I,Tainta M,Prada Á,Castillo-Triviño T,Falcón-Pérez JM,Olascoaga J,Otaegui D

更新日期：2018-08-19 00:00:00

abstract：:The proliferative response of the neuroblastoma line NB69 to a 100 µT, 50 Hz magnetic field (MF) has been shown mediated by activation of the MAPK-ERK1/2 pathway. This work investigates the MF effect on the cell cycle of NB69, the participation of p38 and c-Jun N-terminal (JNK) kinases in the field-induced proliferati...

journal_title：International journal of molecular sciences

authors： Martínez MA,Úbeda A,Moreno J,Trillo MÁ

更新日期：2016-04-06 00:00:00

abstract：:We have considered the Huxley-Simmons manoeuvre. On the assumption that the quick release is an elastic process and on the basis of the isometric tension and of the stiffness of the muscle fibre we calculated that the spontaneous release of the fibre requires approximately 43 micros, which is much faster than the obse...

journal_title：International journal of molecular sciences

authors： Grazi E,Pozzati S

更新日期：2009-03-01 00:00:00

abstract：:The adsorption of amyloidogenic peptides, amyloid beta 1-40 (Aβ1-40), alpha-synuclein (α-syn), and beta 2 microglobulin (β2m), was attempted over the surface of nano-gold colloidal particles, ranging from d = 10 to 100 nm in diameter (d). The spectroscopic inspection between pH 2 and pH 12 successfully extracted the c...

journal_title：International journal of molecular sciences

authors： Yokoyama K,Brown K,Shevlin P,Jenkins J,D'Ambrosio E,Ralbovsky N,Battaglia J,Deshmukh I,Ichiki A

更新日期：2019-10-28 00:00:00

abstract：:Carotenoid cleavage dioxygenases (CCDs) selectively catalyze carotenoids, forming smaller apocarotenoids that are essential for the synthesis of apocarotenoid flavor, aroma volatiles, and phytohormone ABA/SLs, as well as responses to abiotic stresses. Here, 19, 11, and 10 CCD genes were identified in Nicotiana tabacum...

journal_title：International journal of molecular sciences

authors： Zhou Q,Li Q,Li P,Zhang S,Liu C,Jin J,Cao P,Yang Y

更新日期：2019-11-18 00:00:00

abstract：:Lonicera japonica Thunb. is a widely used medicinal plant and is rich in a variety of active ingredients. Flavonoids are one of the important components in L. japonica and their content is an important indicator for evaluating the quality of this herb. To study the regulation of flavonoid biosynthesis in L. japonica, ...

journal_title：International journal of molecular sciences

authors： Qi X,Fang H,Chen Z,Liu Z,Yu X,Liang C

更新日期：2019-09-11 00:00:00

abstract：:Recent studies have demonstrated that strigolactones (SLs) also participate in the regulation of stress adaptation; however, the regulatory mechanism remains elusive. In this study, the homolog of More Axillary Branches 2, which encodes a key component in SL signaling, in the perennial oil plant Sapium sebiferum was i...

journal_title：International journal of molecular sciences

authors： Wang Q,Ni J,Shah F,Liu W,Wang D,Yao Y,Hu H,Huang S,Hou J,Fu S,Wu L

更新日期：2019-02-15 00:00:00

abstract：:Quercetin (QCT) is flavonoid that possesses various biological functions including anti-oxidative and radical-scavenging activities. Moreover, QCT exerts some preventive actions in treatment of cardiovascular diseases. The aim of present study was to explore effects of prolonged administration of QCT on changes induce...

journal_title：International journal of molecular sciences

authors： Barteková M,Šimončíková P,Fogarassyová M,Ivanová M,Okruhlicová Ľ,Tribulová N,Dovinová I,Barančík M

更新日期：2015-04-13 00:00:00

abstract：:To decrease the cost of bioethanol production, biomass recalcitrance needs to be overcome so that the conversion of biomass to bioethanol becomes more efficient. CO(2) laser irradiation can disrupt the lignocellulosic physical structure and reduce the average size of fiber. Analyses with Fourier transform infrared spe...

journal_title：International journal of molecular sciences

authors： Tian SQ,Wang ZY,Fan ZL,Zuo LL

更新日期：2012-01-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, and thus better understanding of its molecular pathology is crucial for us to devise more effective treatment of this deadly disease. As cancer cell line remains a convenient starting point for discovery and proof-of-concept studies, here ...

journal_title：International journal of molecular sciences

authors： Shen Y,Pu K,Zheng K,Ma X,Qin J,Jiang L,Li J

更新日期：2019-09-10 00:00:00

abstract：:Forty mice were randomly divided into four groups on the basis of the diet to be fed as follows: 5% (low) fat diet (T1: LF); 20% (high) fat diet (T2: HF); 20% fat containing 1% conjugated linoleic acid (CLA) (T3: HFC); and 20% fat containing 1% CLA with 0.5% biopolymers (T4: HFCB). The high-fat with CLA diet groups (H...

journal_title：International journal of molecular sciences

authors： Hur SJ,Kim DH,Chun SC,Lee SK

更新日期：2013-03-26 00:00:00

abstract：:Hibiscus aridicola (Malvaceae) is an endangered ornamental shrub endemic to the dry-hot valleys of Jinsha River in southwest China. Only four natural populations of H. aridicola exist in the wild according to our field investigation. It can be inferred that H. aridicola is facing a very high risk of extinction in the ...

journal_title：International journal of molecular sciences

authors： Zhang L,Sun W,Wang Z,Guan K,Yang J

更新日期：2011-01-01 00:00:00

abstract：:Fibrotic diseases, such as liver, pulmonary and renal fibrosis, are common end-stage conditions and represent a major global health problem. Furthermore, effective therapeutic measures are presently unavailable. Extracellular matrix accumulation is the most prominent characteristic in the pathogenesis of fibrotic dise...

journal_title：International journal of molecular sciences

authors： Zhou TB,Drummen GP,Qin YH

更新日期：2012-12-21 00:00:00

abstract：:Carbamazepine (CBZ) binds adenosine receptors, but detailed effects of CBZ on astroglial transmission associated with adenosine receptor still need to be clarified. To clarify adenosinergic action of CBZ on astroglial transmission, primary cultured astrocytes were acutely or chronically treated with CBZ, proinflammato...

journal_title：International journal of molecular sciences

authors： Okada M,Fukuyama K,Shiroyama T,Ueda Y

更新日期：2019-07-30 00:00:00

abstract：:Dietary supplementation with polyunsaturated fatty acids (PUFA) n-3 can affect cutaneous wound healing; however, recent findings demonstrate the variable extent of their influence on the quality of healing. Here, we compare the effect of several dietary oils, containing different levels of PUFA n-3 and PUFA n-6, on wo...

journal_title：International journal of molecular sciences

authors： Komprda T,Sladek Z,Sevcikova Z,Svehlova V,Wijacki J,Guran R,Do T,Lackova Z,Polanska H,Vrlikova L,Popelkova V,Michalek P,Zitka O,Buchtova M

更新日期：2020-10-24 00:00:00

abstract：:ALG-2 is a penta-EF-hand Ca(2+)-binding protein and interacts with a variety of intracellular proteins. Two types of ALG-2-binding motifs have been determined: type 1, PXYPXnYP (X, variable; n = 4), in ALIX and PLSCR3; type 2, PXPGF, in Sec31A and PLSCR3. The previously solved X-ray crystal structure of the complex be...

journal_title：International journal of molecular sciences

authors： Takahashi T,Suzuki H,Inuzuka T,Shibata H,Maki M

更新日期：2012-01-01 00:00:00

abstract：:This review analyzes current studies of the therapeutic effects of Phoenix dactylifera, or date palm fruit, on the physiologic system. Specifically, we sought to summarize the effects of its application in preventing cell damage, improving cancer therapeutics and reducing damage caused by conventional chemotherapy. Ph...

journal_title：International journal of molecular sciences

authors： Yasin BR,El-Fawal HA,Mousa SA

更新日期：2015-12-17 00:00:00

abstract：:Type 2 transglutaminase (TG2) is a ubiquitous enzyme able to modify gliadin peptides introduced into the organism through the diet. By means of its catalytic activity, TG2 seems to have an important pathogenetic role in celiac disease (CD), an inflammatory intestinal disease caused by the ingestion of gluten-containin...

journal_title：International journal of molecular sciences

authors： Paolella G,Nanayakkara M,Sposito S,Lepretti M,Auricchio S,Esposito C,Barone MV,Martucciello S,Caputo I

更新日期：2020-02-12 00:00:00

abstract：:Macrophages can polarize into two different states (M1 and M2), which play contrasting roles during pathogenesis or tissue damage. M1 polarized macrophages produce pro-inflammatory cytokines and mediators resulting in inflammation, while M2 macrophages have an anti-inflammatory effect. Secretion of appropriate cytokin...

journal_title：International journal of molecular sciences

authors： Koh YC,Yang G,Lai CS,Weerawatanakorn M,Pan MH

更新日期：2018-07-28 00:00:00

abstract：:Timely and reliable distinction of sepsis from non-infectious systemic inflammatory response syndrome (SIRS) supports adequate antimicrobial therapy and saves lives but is clinically challenging. Blood transcriptional profiling promises to deliver insights into the pathomechanisms of SIRS and sepsis and to accelerate ...

journal_title：International journal of molecular sciences

authors： Coulibaly A,Velásquez SY,Sticht C,Figueiredo AS,Himmelhan BS,Schulte J,Sturm T,Centner FS,Schöttler JJ,Thiel M,Lindner HA

更新日期：2019-05-09 00:00:00

abstract：:Adlay (Coix larchryma-jobi L.) was the commonly used Traditional Chinese Medicine (TCM) with high content of seed storage protein. The hydrolyzed bioactive oligopeptides of adlay have been proven to be anti-hypertensive effective components. However, the structures and anti-hypertensive mechanism of bioactive oligopep...

journal_title：International journal of molecular sciences

authors： Qiao L,Li B,Chen Y,Li L,Chen X,Wang L,Lu F,Luo G,Li G,Zhang Y

更新日期：2016-12-14 00:00:00

abstract：:Riboswitches are naturally occurring RNA aptamers that control the expression of essential bacterial genes by binding to specific small molecules. The binding with both high affinity and specificity induces conformational changes. Thus, riboswitches were proposed as a possible molecular target for developing antibioti...

journal_title：International journal of molecular sciences

authors： Hu G,Li H,Xu S,Wang J

更新日期：2020-03-11 00:00:00

abstract：:Anthocyanins are the largest class of water soluble plant pigments and a common part of the human diet. They may have many potential health benefits, including antioxidant, anti-inflammatory, anti-cancer, and cardioprotective activities. However, anthocyanin metabolism is not well understood. Studies suggest that anth...

journal_title：International journal of molecular sciences

authors： Atnip AA,Sigurdson GT,Bomser J,Giusti MM

更新日期：2017-02-18 00:00:00

abstract：:Chemerin, a novel adipokine, has been associated with metabolic, inflammatory, and atherosclerotic diseases. We aimed to determine the genetic basis of chemerin levels by conducting a genome-wide association study (GWAS) and to investigate the role of RARRES2 polymorphisms and circulating chemerin levels in the long-t...

journal_title：International journal of molecular sciences

authors： Er LK,Hsu LA,Juang JJ,Chiang FT,Teng MS,Tzeng IS,Wu S,Lin JF,Ko YL

更新日期：2019-03-07 00:00:00

abstract：:Infectious diseases caused by parasites are a major threat for the entire mankind, especially in the tropics. More than 1 billion people world-wide are directly exposed to tropical parasites such as the causative agents of trypanosomiasis, leishmaniasis, schistosomiasis, lymphatic filariasis and onchocerciasis, which ...

journal_title：International journal of molecular sciences

authors： Ndjonka D,Rapado LN,Silber AM,Liebau E,Wrenger C

更新日期：2013-02-06 00:00:00

abstract：BACKGROUND:Our aim was to evaluate the feasibility of a serological assessment of gastric cancer risk in patients undergoing colonoscopy in countries with low-to-moderate incidence rates. METHODS:Serum samples were prospectively collected from 453 patients (>50 years old) undergoing colonoscopies. Of these, 279 (61.6%...

journal_title：International journal of molecular sciences

authors： Selgrad M,Bornschein J,Kandulski A,Weigt J,Roessner A,Wex T,Malfertheiner P

更新日期：2018-12-03 00:00:00