Abstract：
:Macrophages can polarize into two different states (M1 and M2), which play contrasting roles during pathogenesis or tissue damage. M1 polarized macrophages produce pro-inflammatory cytokines and mediators resulting in inflammation, while M2 macrophages have an anti-inflammatory effect. Secretion of appropriate cytokines and chemokines from macrophages can lead to the modification of the microenvironment for bridging innate and adaptive immune responses. Increasing evidence suggests that polarized macrophages are pivotal for disease progression, and the regulation of macrophage polarization may provide a new approach in therapeutic treatment of inflammation-related diseases, including cancer, obesity and metabolic diseases, fibrosis in organs, brain damage and neuron injuries, and colorectal disease. Polarized macrophages affect the microenvironment by secreting cytokines and chemokines while cytokines or mediators that are produced by resident cells or tissues may also influence macrophages behavior. The interplay of macrophages and other cells can affect disease progression, and therefore, understanding the activation of macrophages and the interaction between polarized macrophages and disease progression is imperative prior to taking therapeutic or preventive actions. Manipulation of macrophages can be an entry point for disease improvement, but the mechanism and potential must be understood. In this review, some advanced studies regarding the role of macrophages in different diseases, potential mechanisms involved, and intervention of drugs or phytochemicals, which are effective on macrophage polarization, will be discussed.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Koh YC,Yang G,Lai CS,Weerawatanakorn M,Pan MHdoi
10.3390/ijms19082208subject
Has Abstractpub_date
2018-07-28 00:00:00issue
8issn
1422-0067pii
ijms19082208journal_volume
19pub_type
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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abstract：:n/a. ...
journal_title：International journal of molecular sciences
pub_type： 已发布勘误
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2012-12-27 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-11-05 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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abstract：:Herein, we propose newly designed and synthesized gold nanopeanuts (Au NPes) as supports for cisplatin (cPt) immobilization, dedicated to combined glioblastoma nano-chemo-radiotherapy. Au NPes offer a large active surface, which can be used for drugs immobilization. Transmission electron microscopy (TEM) revealed that...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-11-29 00:00:00
