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P1G10, the Proteolytic Fraction from Vasconcellea cundinamarcensis, Stimulates Tissue Repair after Acute Exposure to Ultraviolet B Radiation.

Abstract：

BACKGROUND:P1G10 is a cysteine proteolytic fraction from Vasconcellea cundinamarcensis latex, obtained by chromatographic separation on Sephadex-G10 and ultrafiltration. This fraction enhances healing in different models of skin lesions, and displays a protective/healing effect against gastric ulcers, where it was suggested an antioxidant role. METHODS:We evaluated here the effect of topical treatment with P1G10, in mice lesions induced by UVB. RESULTS:After single exposure to 2.4 J cm-2 UVB, P1G10 reduced erythema, increased cellularity of hypodermis, enhanced MPO activity and IL1β, and inhibited COX2 levels. These results point to an anti-inflammatory effect by P1G10. This fraction displayed antioxidant activity by reversing the depletion of glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and reducing the catalase activity increased by UVB. These changes may be related to a reduction in MDA observed in groups treated with P1G10. P1G10 also inhibited MMP-9, caspase-3 and pkat while increasing p53 levels.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Freitas KM,Silva ACAE,Veloso ES,Ferreira Ê,Barcelos LS,Caliari MV,Salas CE,Lopes MTP

doi

10.3390/ijms20184373

subject

Has Abstract

pub_date

2019-09-06 00:00:00

issue

18

issn

1422-0067

pii

ijms20184373

journal_volume

20

pub_type

杂志文章

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