Abstract：
:Intracranial malignancies, such as primary brain cancers and brain-localized metastases derived from peripheral cancers, are particularly difficult to treat with therapeutic agents, because the blood-brain barrier (BBB) effectively minimizes brain entry of the vast majority of agents arriving from the systemic circulation. Intranasal administration of cancer drugs has the potential to reach the brain via direct nose-to-brain transport, thereby circumventing the obstacle posed by the BBB. However, in the field of cancer therapy, there is a paucity of studies reporting positive results with this type of approach. A remarkable exception is the natural compound perillyl alcohol (POH). Its potent anticancer activity was convincingly established in preclinical studies, but it nonetheless failed in subsequent clinical trials, where it was given orally and displayed hard-to-tolerate gastrointestinal side effects. Intriguingly, when switched to intranasal delivery, POH yielded highly promising activity in recurrent glioma patients and was well tolerated. As of 2018, POH is the only intranasally delivered compound in the field of cancer therapy (outside of cancer pain) that has advanced to active clinical trials. In the following, we will introduce this compound, summarize its molecular mechanisms of action, and present the latest data on its clinical evaluation as an intranasally administered agent for glioma.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Chen TC,da Fonseca CO,Schönthal AHdoi
10.3390/ijms19123905subject
Has Abstractpub_date
2018-12-06 00:00:00issue
12issn
1422-0067pii
ijms19123905journal_volume
19pub_type
杂志文章,评审abstract：:The floral development in an important legume crop yellow lupine (Lupinus luteus L., Taper cv.) is often affected by the abscission of flowers leading to significant economic losses. Small non-coding RNAs (sncRNAs), which have a proven effect on almost all developmental processes in other plants, might be of key playe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205122
更新日期：2019-10-16 00:00:00
abstract：:Several studies show that triple-negative breast cancer (TNBC) patients have the lowest vitamin D concentration among all breast cancer types, suggesting that this vitamin may induce a protective effect against TNBC. This effect of the active metabolite of vitamin D, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D), can be attr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21103670
更新日期：2020-05-23 00:00:00
abstract：:Though Cnidium officinale Makino (COM) was known to have anti-angiogenic, anti-oxidant, neuroprotective, and anti-cancer effects, the underlying anticancer mechanism of COM using endoplasmic reticulum (ER) stress and miRNA remained unclear until now. Thus, in the current study, the inhibitory mechanism of COM in lymph...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19030865
更新日期：2018-03-15 00:00:00
abstract：:Emotional and cognitive information processing represent higher-order brain functions. They require coordinated interaction of specialized brain areas via a complex spatial and temporal equilibrium among neuronal cell-autonomous, circuitry, and network mechanisms. The delicate balance can be corrupted by stressful exp...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21207455
更新日期：2020-10-09 00:00:00
abstract：:Following herbivore attacks, plants modify a blend of volatiles organic compounds (VOCs) released, resulting in the attraction of their antagonists. However, volatiles released constitutively may affect herbivores and natural enemies' fitness too. In tomato there is still a lack of information on the genetic bases res...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092748
更新日期：2018-09-13 00:00:00
abstract：BACKGROUND:Autologous fat transfer in the form of lipoaspirates for the reconstruction of the breast after breast cancer surgery is a commonly used procedure in plastic surgery. However, concerns regarding the oncologic risk of nutrient-rich fat tissue are widely debated. Previous studies have primarily focused on stud...
journal_title：International journal of molecular sciences
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doi：10.3390/ijms21239171
更新日期：2020-12-01 00:00:00
abstract：:The regeneration of dental tissues is a still an unmet clinical need; in fact, no therapies have been completely successful in regenerating dental tissue complexes such as periodontium, which is also due to the lack of scaffolds that are able to guide and direct cell fate towards the reconstruction of different minera...
journal_title：International journal of molecular sciences
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doi：10.3390/ijms19113604
更新日期：2018-11-15 00:00:00
abstract：:The insulin-like growth factor 2 (IGF2) mRNA binding protein IMP2 (IGF2BP2) is an oncogenic protein known to be overexpressed in different tumor types. Pancreatic cancer is a very lethal cancer that requires early diagnosis and new treatment options. The aim of our study was to investigate the role of IMP2 in the init...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20133204
更新日期：2019-06-29 00:00:00
abstract：:The medicinal herbal plant has been commonly used for prevention and intervention of disease and health promotions worldwide. Brazilein is a bioactive compound extracted from Caesalpinia sappan Linn. Several studies have showed that brazilein exhibited the immune suppressive effect and anti-oxidative function. However...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161126048
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms21196988
更新日期：2020-09-23 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2018-01-23 00:00:00
abstract：:Psychedelic and stimulating phenethylamines belong to the family of new psychoactive substances (NPS). The acute toxicity framework has begun to be investigated, while studies showing genotoxic potential are very limited or not available. Therefore, in order to fill this gap, the aim of the present work was to evaluat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249616
更新日期：2020-12-17 00:00:00
abstract：:Outbred female rats were exposed to inhalation of lead oxide nanoparticle aerosol produced right then and there at a concentration of 1.30 ± 0.10 mg/m3 during 5 days for 4 h a day in a nose-only setup. A control group of rats were sham-exposed in parallel under similar conditions. Even this short-time exposure of a re...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030690
更新日期：2020-01-21 00:00:00
abstract：:Demands for safe depigmentation compounds are constantly increasing in the pharmaceutical and cosmetic industry, since the numerous relevant compounds reported to date have shown undesirable side effects or low anti-melanogenic effects. In this study, we reported three novel inhibitors of tyrosinase, which is the key ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093144
更新日期：2020-04-29 00:00:00
abstract：:Fluorescent silica nanoparticles (FSNPs) can provide high-intensity and photostable fluorescent signals as a probe for biomedical analysis. In this study, FSNPs hybridized with aggregation-induced emission (AIE) luminogens (namely FSNP-SD) were successfully fabricated by a surfactant-free sol-gel method. The FSNP-SD w...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14011080
更新日期：2013-01-07 00:00:00
abstract：:The propagation of hard-branch cuttings of tetraploid Robinia pseudoacacia (black locust) is restricted by the low rooting rate; however, etiolated juvenile tetraploid black locust branches result in a significantly higher rooting rate of cuttings compared with non-etiolated juvenile tetraploid branches. To identify p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15046674
更新日期：2014-04-21 00:00:00
abstract：:Non-melanomatous skin cancers (NMSCs), which include basal and squamous cell carcinoma (BCC and SCC respectively), represent a significant burden on the population, as well as an economic load to the health care system; yet treatments of these preventable cancers remain ineffective. Studies estimate that there has bee...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18071369
更新日期：2017-06-27 00:00:00
abstract：:Octamer-binding transcription factor 4 (Oct4) is a member of POU (Pit-Oct-Unc) transcription factor family Class V that plays a crucial role in maintaining the pluripotency and self-renewal of stem cells. Though it has been deeply investigated in mammals, its lower vertebrate homologue, especially in the marine fish, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18010231
更新日期：2017-01-23 00:00:00
abstract：:Extranodal NK/T-cell lymphoma, nasal type (ENKTL), is an aggressive malignancy with a poor prognosis. While the introduction of L-asparaginase in the treatment of this disease has significantly improved the prognosis, the outcome of patients relapsing after asparaginase-based chemotherapy, which occurs in up to 50% of...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19071931
更新日期：2018-06-30 00:00:00
abstract：:Development of antivirals has focused primarily on vaccines and on treatments for specific viral agents. Although effective, these approaches may be limited in situations where the etiologic agent is unknown or when the target virus has undergone mutation, recombination or reassortment. Augmentation of the innate immu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9091561
更新日期：2008-09-01 00:00:00
abstract：:Elongation of very-long-chain fatty acids 1 (ELOVL1) is a ubiquitously expressed gene that belongs to the ELOVL family and regulates the synthesis of very-long-chain fatty acids (VLCFAs) and sphingolipids, from yeast to mammals. Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of cell metabolism...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160716440
更新日期：2015-07-20 00:00:00
abstract：:In previous studies we produced autism like behavioral changes in mice by Valproic acid (VPA) with significant differences between genders. S-adenosine methionine (SAM) prevented the autism like behavior in both genders. The expression of 770 genes of pathways involved in neurophysiology and neuropathology was studied...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215278
更新日期：2019-10-24 00:00:00
abstract：:The present study was performed to investigate the effects of chronic administration of nonylphenol (NP) on the expression of inflammation-related genes in the brains of mice. NP was given orally by gavages at 0, 50, 100, and 200 mg/kg/d. The expression of inflammatory enzymes, inducible nitric oxide synthase (iNOS) a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9101977
更新日期：2008-10-01 00:00:00
abstract：:Protein inhibitors of proteases are an important tool of nature to regulate and control proteolysis in living organisms under physiological and pathological conditions. In this review, we analyzed the mechanisms of inhibition of cysteine proteases on the basis of structural information and compiled kinetic data. The g...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22030997
更新日期：2021-01-20 00:00:00
abstract：:The presence of lysine (Lys) or arginine (Arg) and tryptophan (Trp) are important for the antimicrobial effects of cationic peptides. Therefore, we designed and synthesized a series of antimicrobial peptides with various numbers of Lys (or Arg) and Trp repeats [(KW and RW)(n)-NH(2), where n equals 2, 3, 4, or 5]. Anti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms131115042
更新日期：2012-11-15 00:00:00
abstract：:Electric field stimulation is known to affect various cellular processes, including cell fate specification and differentiation, particularly towards neuronal lineages. This makes it a promising therapeutic strategy to stimulate regeneration of neuronal tissues. Retinal ganglion cells (RGCs) is a type of neural cells ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20112661
更新日期：2019-05-30 00:00:00
abstract：:A psychrotolerant bacterium, strain T-3 (identified as Psychrobacter piscatorii), that exhibited an extraordinarily high catalase activity was isolated from the drain pool of a plant that uses H(2)O(2) as a bleaching agent. Its cell extract exhibited a catalase activity (19,700 U·mg protein(-1)) that was higher than t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13021733
更新日期：2012-01-01 00:00:00
abstract：:Collaterals are unique blood vessels present in the microcirculation of most tissues that, by cross-connecting a small fraction of the outer branches of adjacent arterial trees, provide alternate routes of perfusion. However, collaterals are especially susceptible to rarefaction caused by aging, other vascular risk fa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20153608
更新日期：2019-07-24 00:00:00
abstract：:Plant mitochondrial NAD-malic enzyme (NAD-ME), which is composed of α- and β-subunits in many species, participates in many plant biosynthetic pathways and in plant respiratory metabolism. However, little is known about the properties of woody plant NAD-MEs. In this study, we analyzed four NAD-ME genes (PtNAD-ME1 thro...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140712994
更新日期：2013-06-24 00:00:00
abstract：:MicroRNAs (miRNAs) are short, non-coding post-transcriptional gene regulators. In mammalian cells, mature miRNAs are produced from primary precursors (pri-miRNAs) using canonical protein machinery, which includes Drosha/DGCR8 and Dicer, or the non-canonical mirtron pathway. In plant cells, mature miRNAs are excised fr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19124075
更新日期：2018-12-17 00:00:00
