Abstract:
:Elongation of very-long-chain fatty acids 1 (ELOVL1) is a ubiquitously expressed gene that belongs to the ELOVL family and regulates the synthesis of very-long-chain fatty acids (VLCFAs) and sphingolipids, from yeast to mammals. Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of cell metabolism and is associated with fatty acids synthesis. In this study, we cloned the cDNA that encodes Cashmere goat (Capra hircus) ELOVL1 (GenBank Accession number KF549985) and investigated its expression in 10 tissues. ELOVL1 cDNA was 840 bp, encoding a deduced protein of 279 amino acids, and ELOVL1 mRNA was expressed in a wide range of tissues. Inhibition of mTORC1 by rapamycin decreased ELOVL1 expression and fatty acids synthesis in Cashmere goat fetal fibroblasts. These data show that ELOVL1 expression is regulated by mTORC1 and that mTORC1 has significant function in fatty acids synthesis in Cashmere goat.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Wang W,He Q,Guo Z,Yang L,Bao L,Bao W,Zheng X,Wang Y,Wang Zdoi
10.3390/ijms160716440subject
Has Abstractpub_date
2015-07-20 00:00:00pages
16440-53issue
7issn
1422-0067pii
ijms160716440journal_volume
16pub_type
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