Abstract：
:Outbred female rats were exposed to inhalation of lead oxide nanoparticle aerosol produced right then and there at a concentration of 1.30 ± 0.10 mg/m3 during 5 days for 4 h a day in a nose-only setup. A control group of rats were sham-exposed in parallel under similar conditions. Even this short-time exposure of a relatively low level was associated with nanoparticles retention demonstrable by transmission electron microscopy in the lungs and the olfactory brain. Some impairments were found in the organism's status in the exposed group, some of which might be considered lead-specific toxicological outcomes (in particular, increase in reticulocytes proportion, in δ-aminolevulinic acid (δ-ALA) urine excretion, and the arterial hypertension's development).
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Sutunkova MP,Solovyeva SN,Chernyshov IN,Klinova SV,Gurvich VB,Shur VY,Shishkina EV,Zubarev IV,Privalova LI,Katsnelson BAdoi
10.3390/ijms21030690subject
Has Abstractpub_date
2020-01-21 00:00:00issue
3issn
1422-0067pii
ijms21030690journal_volume
21pub_type
杂志文章abstract：:Oral squamous cell carcinoma (OSCC) typically migrates and metastasizes. Interleukin-6 (IL-6) is a multifunctional cytokine associated with disease status and cancer outcomes. The effect of IL-6 on human OSCC cells, however, is unknown. Here, we showed that IL-6 increased cell migration and Intercellular adhesion mole...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15010545
更新日期：2014-01-06 00:00:00
abstract：:Androgen insensitivity syndrome (AIS), manifesting incomplete virilization in 46,XY individuals, is caused mostly by androgen receptor (AR) gene mutations. Therefore, a search for AR mutations is a routine approach in AIS diagnosis. However, some AIS patients lack AR mutations, which complicates the diagnosis. Here, w...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-11-09 00:00:00
abstract：:In addition to its role in ribosome biogenesis, ribosomal protein S3 (RPS3), a component of the 40S ribosomal subunit, has been suggested to possess several extraribosomal functions, including an apoptotic function. In this study, we demonstrated that in the mouse brain, the protein levels of RPS3 were altered by the ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092723
更新日期：2018-09-12 00:00:00
abstract：:The synergistic anticancer effect of docetaxel (DTX) and curcumin (CCM) has emerged as an attractive therapeutic candidate for lung cancer treatment. However, the lack of optimal bioavailability because of high toxicity, low stability, and poor solubility has limited their clinical success. Given this, an aerosolized ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124357
更新日期：2020-06-19 00:00:00
abstract：:The development of stimulus-responsive photosensitizer delivery systems that carry a high payload of photosensitizers is of great importance in photodynamic therapy. In this study, redox-responsive polysilsesquioxane nanoparticles (PSilQNPs) built by a reverse microemulsion approach using 5,10,15,20-tetrakis(carboxyph...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17010056
更新日期：2015-12-31 00:00:00
abstract：:Synthesis of the CCA end of essential tRNAs is performed either by CCA-adding enzymes or as a collaboration between enzymes restricted to CC- and A-incorporation. While the occurrence of such tRNA nucleotidyltransferases with partial activities seemed to be restricted to Bacteria, the first example of such split CCA-a...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2017-11-28 00:00:00
abstract：:Epigenetic alterations by promoter DNA hypermethylation and gene silencing in cancer have been reported over the past few decades. DNA hypermethylation has great potential to serve as a screening marker, a prognostic marker, and a therapeutic surveillance marker in cancer clinics. Some bodily fluids, such as stool or ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2017-03-30 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2017-06-26 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2009-07-10 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-08-17 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-09-11 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2018-07-08 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-12-25 00:00:00
