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D-(+)-galactose-conjugated single-walled carbon nanotubes as new chemical probes for electrochemical biosensors for the cancer marker galectin-3.

Abstract：

:D-(+)-Galactose-conjugated single-walled carbon nanotubes (SWCNTs) were synthesized for use as biosensors to detect the cancer marker galectin-3. To investigate the binding of galectin-3 to the d-(+)-galactose-conjugated SWCNTs, an electrochemical biosensor was fabricated by using molybdenum electrodes. The binding affinities of the conjugated SWCNTs to galectin-3 were quantified using electrochemical sensitivity measurements based on the differences in resistance together with typical I-V characterization. The electrochemical sensitivity measurements of the d-(+)-galactose-conjugated SWCNTs differed significantly between the samples with and without galectin-3. This indicates that d-(+)-galactose-conjugated SWCNTs are potentially useful electrochemical biosensors for the detection of cancer marker galectin-3.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Park YK,Bold B,Lee WK,Jeon MH,An KH,Jeong SY,Shim YK

doi

10.3390/ijms12052946

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

2946-57

issue

5

issn

1422-0067

pii

ijms-12-02946

journal_volume

12

pub_type

杂志文章

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