Abstract：
:Oxidative stress plays a key role for the development of cardiovascular, metabolic, and neurodegenerative disease. This concept has been proven by using the approach of genetic deletion of reactive oxygen and nitrogen species (RONS) producing, pro-oxidant enzymes as well as by the overexpression of RONS detoxifying, antioxidant enzymes leading to an amelioration of the severity of diseases. Vice versa, the development and progression of cardiovascular diseases is aggravated by overexpression of RONS producing enzymes as well as deletion of RONS detoxifying enzymes. We have previously identified cross talk mechanisms between different sources of RONS, which can amplify the oxidative stress-mediated damage. Here, the pathways and potential mechanisms leading to this cross talk are analyzed in detail and highlighted by selected examples from the current literature and own data including hypoxia, angiotensin II (AT-II)-induced hypertension, nitrate tolerance, aging, and others. The general concept of redox-based activation of RONS sources via "kindling radicals" and enzyme-specific "redox switches" as well as the interaction with redox-sensitive inflammatory pathways are discussed. Here, we present evidence for the existence of such cross talk mechanisms in the setting of diabetes and critically assess their contribution to the severity of diabetic complications.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Daiber A,Steven S,Vujacic-Mirski K,Kalinovic S,Oelze M,Di Lisa F,Münzel Tdoi
10.3390/ijms21103405subject
Has Abstractpub_date
2020-05-12 00:00:00issue
10issn
1422-0067pii
ijms21103405journal_volume
21pub_type
杂志文章,评审abstract：:Glioblastoma (GBM) present with an abundant and aberrant tumor neo-vasculature. While rapid growth of solid tumors depends on the initiation of tumor angiogenesis, GBM also progress by infiltrative growth and vascular co-option. The angiogenic factor apelin (APLN) and its receptor (APLNR) are upregulated in GBM patien...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21114179
更新日期：2020-06-11 00:00:00
abstract：:The plant hormone auxin plays pivotal roles in many aspects of plant growth and development. The auxin/indole-3-acetic acid (Aux/IAA) gene family encodes short-lived nuclear proteins acting on auxin perception and signaling, but the evolutionary history of this gene family remains to be elucidated. In this study, the ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18102107
更新日期：2017-10-08 00:00:00
abstract：:Plant phenolics have shown to activate apoptotic cell death in different tumourigenic cell lines. In this study, we evaluated the effects of juniper berry extract (Juniperus communis L.) on p53 protein, gene expression and DNA fragmentation in human neuroblastoma SH-SY5Y cells. In addition, we analyzed the phenolic co...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17071113
更新日期：2016-07-13 00:00:00
abstract：:Paired box gene 3 (Pax3) and cAMP responsive element-binding protein (CREB) directly interact with the cis-acting elements on the promoter of microphthalmia-associated transcription factor isoform M (MITF-M) for transcriptional activation in the melanogenic process. Tyrosinase (Tyro) is a target gene of MITF-M, and fu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-12-17 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-03-03 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-09-18 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2017-03-28 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20112748
更新日期：2019-06-04 00:00:00
abstract：:Hypoxia, a common factor ruling the microenvironment composition, leads to tumor progression. In this hypoxic context, cytokines and cells cooperate to favor cancer development and metastasis. Tumor hypoxia is heterogeneously distributed. Oxygen gradients depend on the vicinity, functionality of blood vessels, and oxy...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-12-14 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-06-10 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2018-04-26 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-12-15 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-10-09 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-06-18 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-01-15 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9081393
更新日期：2008-08-01 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20082043
更新日期：2019-04-25 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19010012
更新日期：2017-12-21 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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pub_type： 临床试验,杂志文章,多中心研究
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journal_title：International journal of molecular sciences
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更新日期：2019-09-19 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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