Abstract：
:Endometriosis is characterized by the presence of endometrial tissue outside the uterus. While endometriotic tissue is commonly localized in the pelvic cavity, it can also be found in distant sites, including the brain. The origin and pathophysiology of tissue migration is poorly understood; retrograde menstruation is thought to be the cause, although the presence of endometrium at distant sites is not explained by this hypothesis. To determine whether dissemination occurs via the bloodstream in women with endometriosis, we analyzed circulating blood for the presence of endometrial cells. Circulating endometrial stromal cells were identified only in women with endometriosis but not in controls, while endometrial epithelial cells were not identified in the circulation of either group. Our results support the hypothesis that endometrial stromal cells may migrate through circulation and promote the pathophysiology of endometriosis. The detection of these cells in circulation creates avenues for the development of less invasive diagnostic tools for the disease, and opens possibilities for further study of the origin of endometriosis.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Vallvé-Juanico J,López-Gil C,Ballesteros A,Santamaria Xdoi
10.3390/ijms20153740subject
Has Abstractpub_date
2019-07-31 00:00:00issue
15issn
1422-0067pii
ijms20153740journal_volume
20pub_type
杂志文章abstract：:Glu-1Ay, one of six genes encoding a high molecular weight glutenin subunit (HMW-GS), is frequently silenced in hexaploid common wheat. Here, an active allele of Glu-1Ay was integrated from wild emmer wheat (Triticum turgidum ssp. dicoccoides) accession D97 into the common wheat (Triticum aestivum) cultivar Chuannong ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19040923
更新日期：2018-03-21 00:00:00
abstract：:The p53 family of transcription factors plays key roles in development, genome stability, senescence and tumor development, and p53 is the most important tumor suppressor protein in humans. Although intensively investigated for many years, its initial evolutionary history is not yet fully elucidated. Using bioinformat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010006
更新日期：2019-12-18 00:00:00
abstract：:TCDD-inducible poly-ADP-ribose polymerase (TIPARP) is an aryl hydrocarbon receptor (AHR) target gene that functions as part of a negative feedback loop to repress AHR activity. Tiparp-/- mice exhibit increased sensitivity to the toxicological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), including lethal wast...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092312
更新日期：2019-05-10 00:00:00
abstract：:The aim of this study was to develop and evaluate matrix assisted LASER desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry imaging (MSI) of blood smear. Integrated light microscope and MALDI IT-TOF mass spectrometer, together with a matrix sublimation device, were used for analysis of blood smears co...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020585
更新日期：2021-01-08 00:00:00
abstract：:Primary biliary cholangitis (PBC) is an immune-mediated cholestatic disease. Vitamin D receptor (VDR)-dependent signaling constrains an inflammatory response by targeting the miRNA155-SOCS1 (suppressor of cytokine signaling 1) axis. The VDR-miRNA155-SOCS1 pathway was investigated in the context of the autoimmune respo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020289
更新日期：2017-01-29 00:00:00
abstract：:Cholangiocarcinoma (CCA) is the second most common type of liver cancer, and is highly aggressive with very poor prognosis. CCA is classified into intrahepatic cholangiocarcinoma (iCCA) and extra-hepatic cholangiocarcinoma (eCCA), which is further stratified into perihilar (pCCA) and distal (dCCA). Cancer stem cells (...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20174154
更新日期：2019-08-25 00:00:00
abstract：:Immunomodulation is increasingly being recognised as a part of mental diseases. Here, we examined whether levels of immunological protein markers changed with depression, age, or the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). An analysis of plasma samples from patients with a major depressive episode ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246172
更新日期：2019-12-06 00:00:00
abstract：:Powdery mildew caused by Blumeria graminis f. sp. tritici (Bgt) is one of many severe diseases that threaten bread wheat (Triticum aestivum L.) yield and quality worldwide. The discovery and deployment of powdery mildew resistance genes (Pm) can prevent this disease epidemic in wheat. In a previous study, we transferr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010322
更新日期：2020-01-03 00:00:00
abstract：:Anthraquinones (AQs) and phenolic compounds are important phytochemicals that are biosynthesized in cell suspension cultures of Polygonum multiflorum. We wanted to optimize the effects of plant growth regulators (PGRs), media, sucrose, l-glutamine, jasmonic acid (JA), and salicylic acid (SA) for the production of phyt...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17111912
更新日期：2016-11-16 00:00:00
abstract：:Cell therapy is an innovative strategy for tissue repair, since adult stem cells could have limited regenerative ability as in the case of myocardial damage. This leads to a local contractile dysfunction due to scar formation. For these reasons, refining strategy approaches for "in vitro" stem cell commitment, prepara...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082324
更新日期：2018-08-08 00:00:00
abstract：:The aim of this study was to select effective and safe microbiocides for the disinfection and protection of historical wooden surfaces at the former Auschwitz II-Birkenau concentration and extermination camp. We tested seven active compounds against bacteria and moulds, of which didecyldimethylammonium chloride and N-...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17081364
更新日期：2016-08-22 00:00:00
abstract：:Transcription factors are proteins able to bind DNA and induce the transcription of specific genes. Consequently, they play a pivotal role in multiple cellular pathways and are frequently over-expressed or dysregulated in cancer. Here, we will focus on a specific "signal transducer and activator of transcription" (STA...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19061591
更新日期：2018-05-28 00:00:00
abstract：:Chronic infection with hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC). Novel treatments with direct-acting antivirals achieve high rates of sustained virologic response; however, the HCC risk remains elevated in cured patients, especially those with advanced liver disease. Long-term HCV inf...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21093057
更新日期：2020-04-26 00:00:00
abstract：:The objective of this article was to document the energy-transducing and regulatory interactions in supramolecular complexes such as motor, pump, and clock ATPases. The dynamics and structural features were characterized by motion and distance measurements using spin-labeling electron paramagnetic resonance (EPR) spec...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21020672
更新日期：2020-01-20 00:00:00
abstract：:Although mitochondrial dysfunction has been implicated in aging, physical function decline, and several age-related diseases, an accessible and affordable measure of mitochondrial health is still lacking. In this study we identified the proteomic signature of muscular mitochondrial oxidative capacity in plasma. In 165...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249540
更新日期：2020-12-15 00:00:00
abstract：:Chlorogenic acid (CGA) is a widely applied traditional Chinese medicine ingredient which can be used for the treatment of osteoporosis. In this experiment, we investigated the potential therapeutic effect of chlorogenic acid on thiram-induced tibial dyschondroplasia (TD) and explored the underlying mechanisms that hav...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20133160
更新日期：2019-06-28 00:00:00
abstract：:Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the acid β-glucosidase gene (GBA1). Besides causing GD, GBA1 mutations constitute the main genetic risk factor for developing Parkinson's disease. The molecular basis of neurological manifestations in GD remain elusive. Ho...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093268
更新日期：2020-05-05 00:00:00
abstract：:Regulation of melanogenesis has been the focus of treatment for hyperpigmentary skin disorders. Although hesperidin is one of the most well-known, naturally occurring flavonoids with antioxidant and anti-inflammatory effect, its anti-melanogenic effect is not known. The present study aims to determine the anti-melanog...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160818384
更新日期：2015-08-07 00:00:00
abstract：BACKGROUND:Although particular matter (PM) increases incidence and severity of idiopathic pulmonary fibrosis, the underlying mechanism remains elusive. METHODS:The effects of PM were evaluated in a murine model of bleomycin-induced pulmonary fibrosis. Mice were divided into four groups, receiving: (1) Saline (control)...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010227
更新日期：2019-12-28 00:00:00
abstract：:Phenolic compounds, which are secondary plant metabolites, are considered an integral part of the human diet. Physiological properties of dietary polyphenols have come to the attention in recent years. Especially, proanthocyanidins (ranging from dimers to decamers) have demonstrated potential interactions with biologi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020376
更新日期：2017-02-10 00:00:00
abstract：:Chemoradiation-based bladder preservation therapy (BPT) is currently a curative option for non-metastatic muscle-invasive bladder cancer (MIBC) patients at favorable risk or an alternative to radical cystectomy (RC) for those who are unfit for RC. In BPT, only patients who achieve complete response (CR) after chemorad...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19092777
更新日期：2018-09-15 00:00:00
abstract：:For bone regeneration, a biocompatible thermo-gelling hydrogel, hyaluronic acid-g-chitosan-g-poly(N-isopropylacrylamide) (HA-CPN) was used as a three-dimensional organic gel matrix for entrapping rabbit adipose-derived stem cells (rASCs). Biphasic calcium phosphate (BCP) ceramic microparticles were embedded within the...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092537
更新日期：2018-08-27 00:00:00
abstract：:Biblical references aside, restoring vision to the blind has proven to be a major technical challenge. In recent years, considerable advances have been made towards this end, especially when retinal degeneration underlies the vision loss such as occurs with retinitis pigmentosa. Under these conditions, optogenetic the...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020522
更新日期：2020-01-14 00:00:00
abstract：:Pectin methylesterase inhibitor genes (PMEIs) are a large multigene family and play crucial roles in cell wall modifications in plant growth and development. Here, a comprehensive analysis of the PMEI gene family in Brassicacampestris, an important leaf vegetable, was performed. We identified 100 BrassicacampestrisPME...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19051338
更新日期：2018-05-02 00:00:00
abstract：:The current knowledge about neuroprotective mechanisms in humans after status epilepticus is scarce. One reason is the difficulty to measure possible mediators of these neuroprotective mechanisms. The dawn of microRNA detection in the cerebrospinal fluid (CSF) and the recent advancements in measuring proteins in the C...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18030490
更新日期：2017-02-24 00:00:00
abstract：:Spinocerebellar ataxia type 3 (SCA3) is a devastating neurodegenerative disease for which there is currently no cure, nor effective treatment strategy. One of nine polyglutamine disorders known to date, SCA3 is clinically heterogeneous and the main feature is progressive ataxia, which in turn affects speech, balance a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215434
更新日期：2019-10-31 00:00:00
abstract：:Compared to solid tumors, the role of PD-L1 in hematological malignancies is less explored, and the knowledge in this area is mostly limited to lymphomas. However, several studies indicated that PD-L1 is also overexpressed in myeloid malignancies. Successful treatment of the acute myeloid leukemia (AML) is likely asso...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20112823
更新日期：2019-06-10 00:00:00
abstract：:Accurate prediction of the potential hepatotoxic nature of new pharmaceuticals remains highly challenging. Therefore, novel in vitro models with improved external validity are needed to investigate hepatic metabolism and timely identify any toxicity of drugs in humans. In this study, we examined the effects of diclofe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17040584
更新日期：2016-04-16 00:00:00
abstract：:The spleen plays an important role in coordinating both adaptive and innate immune responses. Here, the transcriptional response to T. gondii infection in the murine spleen was characterized concerning inflammasome sensors (two different models: seven days after oral or four weeks after intraperitoneal infection). Add...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18061245
更新日期：2017-06-10 00:00:00
abstract：:The progression of cancer is associated with increases in amino acid uptake by cancer cells. Upon their entry into cells through specific transporters, exogenous amino acids are used to synthesize proteins, nucleic acids and lipids and to generate ATP. The essential amino acid leucine is also important for maintaining...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19082373
更新日期：2018-08-12 00:00:00
