Abstract：
:Self-assembling peptides have been employed as biotemplates for biomineralization, as the morphologies and sizes of the inorganic materials can be easily controlled. We synthesized two types of highly ordered self-assembling peptides with different secondary structures and investigated the effects of secondary structures on hydroxyapatite (HAp) biomineralization of peptide templates. All as-synthesized HAp-peptides have a selective protein adsorption capacity for basic protein (e.g., cytochrome c and lysozyme). Moreover, the selectivity was improved as peptide amounts increased. In particular, peptide-HAp templated on β-sheet peptides adsorbed more cytochrome c than peptide-HAp with α-helix structures, due to the greater than 2-times carboxyl group density at their surfaces. It can be expected that self-assembled peptide-templated HAp may be used as carriers for protein immobilization in biosensing and bioseparation applications and as enzyme-stabilizing agents.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Kojima S,Nakamura H,Lee S,Nagata F,Kato Kdoi
10.3390/ijms20184650subject
Has Abstractpub_date
2019-09-19 00:00:00issue
18issn
1422-0067pii
ijms20184650journal_volume
20pub_type
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