Abstract：
:The combination of an antifungal agent and drug carrier with adjunctive antimicrobial properties represents novel strategy of complex therapy in pharmaceutical technology. The goal of this study was to investigate the unmodified and ion cross-linked chitosan's influence on anti-Candida activity of clotrimazole used as a model drug in hydrogels. It was particularly crucial to explore whether the chitosans' structure modification by β-glycerophosphate altered its antifungal properties. Antifungal studies (performed by plate diffusion method according to CLSI reference protocol) revealed that hydrogels obtained with chitosan/β-glycerophosphate displayed lower anti-Candida effect, probably as a result of weakened polycationic properties of chitosan in the presence of ion cross-linker. Designed chitosan hydrogels with clotrimazole were found to be more efficient against tested Candida strains and showed more favorable drug release profile compared to commercially available product. These observations indicate that novel chitosan formulations may be considered as promising semi-solid delivery system of clotrimazole.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Szymańska E,Winnicka K,Wieczorek P,Sacha PT,Tryniszewska EAdoi
10.3390/ijms151017765subject
Has Abstractpub_date
2014-09-30 00:00:00pages
17765-77issue
10issn
1422-0067pii
ijms151017765journal_volume
15pub_type
杂志文章abstract：:Marine environments harbor a wide range of microorganisms from the three domains of life. These microorganisms have great potential to enable discovery of new enzymes and bioactive compounds for industrial use. However, only ~1% of microorganisms from the environment can currently be identified through cultured isolat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2015-11-27 00:00:00
abstract：:Biomarkers for the early detection of pancreatic cancer are urgently needed. The aim of this pilot study was to evaluate changes in serum N-glycoproteins and their glycosylation status prior to clinical presentation of pancreatic cancer that may be potential biomarkers. Prediagnosis serum samples pooled according to f...
journal_title：International journal of molecular sciences
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abstract：:Acute liver failure (ALF) leads to neurological symptoms defined as hepatic encephalopathy (HE). Although accumulation of ammonia and neuroinflammation are generally accepted as main contributors to HE pathomechanism, a buildup of bile acids (BA) in the blood is a frequent component of liver injury in HE patients. Rec...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2019-09-27 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2020-12-28 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-05-21 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2015-05-18 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-04-07 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-09-19 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-08-28 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-10-26 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms12031605
更新日期：2011-01-01 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-01-01 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2020-03-25 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-03-07 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-06-25 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2009-09-10 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2012-01-01 00:00:00
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journal_title：International journal of molecular sciences
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