当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > JNK Signaling as a Key Modulator of Soft Connective Tissue Physiology, Pathology, and Healing.

JNK Signaling as a Key Modulator of Soft Connective Tissue Physiology, Pathology, and Healing.

Abstract：

:In healthy individuals, the healing of soft tissues such as skin after pathological insult or post injury follows a relatively predictable and defined series of cell and molecular processes to restore tissue architecture and function(s). Healing progresses through the phases of hemostasis, inflammation, proliferation, remodeling, and concomitant with re-epithelialization restores barrier function. Soft tissue healing is achieved through the spatiotemporal interplay of multiple different cell types including neutrophils, monocytes/macrophages, fibroblasts, endothelial cells/pericytes, and keratinocytes. Expressed in most cell types, c-Jun N-terminal kinases (JNK) are signaling molecules associated with the regulation of several cellular processes involved in soft tissue wound healing and in response to cellular stress. A member of the mitogen-activated protein kinase family (MAPK), JNKs have been implicated in the regulation of inflammatory cell phenotype, as well as fibroblast, stem/progenitor cell, and epithelial cell biology. In this review, we discuss our understanding of JNKs in the regulation of cell behaviors related to tissue injury, pathology, and wound healing of soft tissues. Using models as diverse as Drosophila, mice, rats, as well as human tissues, research is now defining important, but sometimes conflicting roles for JNKs in the regulation of multiple molecular processes in multiple different cell types central to wound healing processes. In this review, we focus specifically on the role of JNKs in the regulation of cell behavior in the healing of skin, cornea, tendon, gingiva, and dental pulp tissues. We conclude that while parallels can be drawn between some JNK activities and the control of cell behavior in healing, the roles of JNK can also be very specific modes of action depending on the tissue and the phase of healing.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Nikoloudaki G,Brooks S,Peidl AP,Tinney D,Hamilton DW

doi

10.3390/ijms21031015

subject

Has Abstract

pub_date

2020-02-04 00:00:00

issue

issn

1422-0067

pii

ijms21031015

journal_volume

pub_type

杂志文章,评审

在线工具

JNK Signaling as a Key Modulator of Soft Connective Tissue Physiology, Pathology, and Healing.