Abstract：
:Poly-γ-glutamic acid (γ-PGA) is a biodegradable biopolymer produced by several bacteria, including Bacillus subtilis and other Bacillus species; it has good biocompatibility, is non-toxic, and has various potential biological applications in the food, pharmaceutical, cosmetic, and other industries. In this review, we have described the mechanisms of γ-PGA synthesis and gene regulation, its role in fermentation, and the phylogenetic relationships among various pgsBCAE, a biosynthesis gene cluster of γ-PGA, and pgdS, a degradation gene of γ-PGA. We also discuss potential applications of γ-PGA and highlight the established genetic recombinant bacterial strains that produce high levels of γ-PGA, which can be useful for large-scale γ-PGA production.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Hsueh YH,Huang KY,Kunene SC,Lee TYdoi
10.3390/ijms18122644subject
Has Abstractpub_date
2017-12-07 00:00:00issue
12issn
1422-0067pii
ijms18122644journal_volume
18pub_type
杂志文章,评审abstract：:Protein kinase is a novel therapeutic target for human diseases. The off-target and side effects of ATP-competitive inhibitors preclude them from the clinically relevant drugs. The compounds targeting the druggable allosteric sites outside the highly conversed ATP binding pocket have been identified as promising alter...
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journal_title：International journal of molecular sciences
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