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Regulation of miRNA expression by low-level laser therapy (LLLT) and photodynamic therapy (PDT).

Abstract：

:Applications of laser therapy, including low-level laser therapy (LLLT), phototherapy and photodynamic therapy (PDT), have been proven to be beneficial and relatively less invasive therapeutic modalities for numerous diseases and disease conditions. Using specific types of laser irradiation, specific cellular activities can be induced. Because multiple cellular signaling cascades are simultaneously activated in cells exposed to lasers, understanding the molecular responses within cells will aid in the development of laser therapies. In order to understand in detail the molecular mechanisms of LLLT and PDT-related responses, it will be useful to characterize the specific expression of miRNAs and proteins. Such analyses will provide an important source for new applications of laser therapy, as well as for the development of individualized treatments. Although several miRNAs should be up- or down-regulated upon stimulation by LLLT, phototherapy and PDT, very few published studies address the effect of laser therapy on miRNA expression. In this review, we focus on LLLT, phototherapy and PDT as representative laser therapies and discuss the effects of these therapies on miRNA expression.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Kushibiki T,Hirasawa T,Okawa S,Ishihara M

doi

10.3390/ijms140713542

subject

Has Abstract

pub_date

2013-06-27 00:00:00

pages

13542-58

issue

7

issn

1422-0067

pii

ijms140713542

journal_volume

14

pub_type

杂志文章

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