Abstract：
:The pandemic of coronavirus disease 2019 (COVID-19), with rising numbers of patients worldwide, presents an urgent need for effective treatments. To date, there are no therapies or vaccines that are proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several potential candidates or repurposed drugs are under investigation, including drugs that inhibit SARS-CoV-2 replication and block infection. The most promising therapy to date is remdesivir, which is US Food and Drug Administration (FDA) approved for emergency use in adults and children hospitalized with severe suspected or laboratory-confirmed COVID-19. Herein we summarize the general features of SARS-CoV-2's molecular and immune pathogenesis and discuss available pharmacological strategies, based on our present understanding of SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) infections. Finally, we outline clinical trials currently in progress to investigate the efficacy of potential therapies for COVID-19.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Zhand S,Saghaeian Jazi M,Mohammadi S,Tarighati Rasekhi R,Rostamian G,Kalani MR,Rostamian A,George J,Douglas MWdoi
10.3390/ijms21155559subject
Has Abstractpub_date
2020-08-03 00:00:00issue
15issn
1422-0067pii
ijms21155559journal_volume
21pub_type
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