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New antifungal pyranoisoflavone from Ficus tikoua Bur.

Abstract：

:Considering the undesirable attributes of synthetic fungicides and the availability of Ficus species in China, the stem of Ficus tikoua Bur. was investigated. One new antifungal pyranoisoflavone, 5,3',4'-trihydroxy-2″,2″-dimethylpyrano (5″,6″:7,8) isoflavone (1), together with two known isoflavones, wighteone (2) and lupiwighteone (3) (with previously reported antifungal activities), were isolated from ethyl acetate extract by bioassay-guided fractionation. Their structures were determined by spectroscopic analysis, such as NMR ((1)H-(1)H COSY, HMQC, HMBC and NOESY), IR, UV and HRMS, as well as ESI-MS(n) analyses. The antifungal activities of 1-3 against Phytophthora infestans were evaluated by direct spore germination assay, and the IC(50) values were 262.442, 198.153 and 90.365 μg·mL(-1), respectively.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Wei S,Wu W,Ji Z

doi

10.3390/ijms13067375

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

7375-82

issue

6

issn

1422-0067

pii

ijms-13-07375

journal_volume

13

pub_type

杂志文章

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