Soft-MS and Computational Mapping of Oleuropein.

Abstract:

:Olive oil and table olives are rich sources of biophenols, which provides a unique taste, aroma and potential health benefits. Specifically, green olive drupes are enriched with oleuropein, a bioactive biophenol secoiridoid. Olive oil contains hydrolytic derivatives such as hydroxytyrosol, oleacein and elenolate from oleuropein as well as tyrosol and oleocanthal from ligstroside. Biophenol secoiridoids are categorized by the presence of elenoic acid or its derivatives in their molecular structure. Medical studies suggest that olive biophenol secoiridoids could prevent cancer, obesity, osteoporosis, and neurodegeneration. Therefore, understanding the biomolecular dynamics of oleuropein can potentially improve olive-based functional foods and nutraceuticals. This review provides a critical assessment of oleuropein biomolecular mechanism and computational mapping that could contribute to nutrigenomics.

journal_name

Int J Mol Sci

authors

Gentile L,Uccella NA,Sivakumar G

doi

10.3390/ijms18050992

subject

Has Abstract

pub_date

2017-05-06 00:00:00

issue

5

issn

1422-0067

pii

ijms18050992

journal_volume

18

pub_type

杂志文章,评审
  • Bio-guided isolation of the cytotoxic terpenoids from the roots of Euphorbia kansui against human normal cell lines L-O2 and GES-1.

    abstract::The dried roots of Euphorbia kansui (kansui) have been used for centuries in China as a herbal medicine for edema, ascites, and asthma. The 95% ethanol extract showed a significant inhibition of cell proliferation against human normal cell lines L-O2 and GES-1. Bioassay-guided separation of the 95% ethanol extract fro...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms130911247

    authors: Zhang L,Gao L,Li Z,Yan X,Yang Y,Tang Y,Cao Y,Ding A

    更新日期:2012-01-01 00:00:00

  • Brassinosteroid Signaling in Plant⁻Microbe Interactions.

    abstract::As sessile organisms, plants are frequently exposed to different stress conditions caused by either biotic or abiotic factors. Understanding the mechanisms that underlie plant interaction with the biotic and abiotic environments is fundamental to both plant biotechnology and sustainable agriculture. Brassinosteroids (...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19124091

    authors: Yu MH,Zhao ZZ,He JX

    更新日期:2018-12-17 00:00:00

  • Dynamic nature of noncoding RNA regulation of adaptive immune response.

    abstract::Immune response plays a fundamental role in protecting the organism from infections; however, dysregulation often occurs and can be detrimental for the organism, leading to a variety of immune-mediated diseases. Recently our understanding of the molecular and cellular networks regulating the immune response, and, in p...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms140917347

    authors: Curtale G,Citarella F

    更新日期:2013-08-22 00:00:00

  • NET4 Modulates the Compactness of Vacuoles in Arabidopsis thaliana.

    abstract::The dimension of the plants largest organelle-the vacuole-plays a major role in defining cellular elongation rates. The morphology of the vacuole is controlled by the actin cytoskeleton, but molecular players remain largely unknown. Recently, the Networked (NET) family of membrane-associated, actin-binding proteins ha...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20194752

    authors: Kaiser S,Eisa A,Kleine-Vehn J,Scheuring D

    更新日期:2019-09-25 00:00:00

  • Identifying Common Features in the Activation of Melanocortin-2 Receptors: Studies on the Xenopus tropicalis Melanocortin-2 Receptor.

    abstract::The interaction between the pituitary hormone, adrenocorticotropin (ACTH), and melanocortin-2 receptor (MC2R) orthologs involves the H6 F7 R8 W9 and R/K15 K16 R17 R18 motifs in ACTH making contact with corresponding contact sites on MC2R. Earlier studies have localized the common HFRW binding site of all melanocortin ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20174166

    authors: Davis PE,Wilkinson EC,Dores RM

    更新日期:2019-08-26 00:00:00

  • Can We Prevent Mitochondrial Dysfunction and Diabetic Cardiomyopathy in Type 1 Diabetes Mellitus? Pathophysiology and Treatment Options.

    abstract::Type 1 diabetes mellitus is a disease involving changes to energy metabolism. Chronic hyperglycemia is a major cause of diabetes complications. Hyperglycemia induces mechanisms that generate the excessive production of reactive oxygen species, leading to the development of oxidative stress. Studies with animal models ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21082852

    authors: Cieluch A,Uruska A,Zozulinska-Ziolkiewicz D

    更新日期:2020-04-19 00:00:00

  • Enhancement of Biomimetic Enzymatic Mineralization of Gellan Gum Polysaccharide Hydrogels by Plant-Derived Gallotannins.

    abstract::Mineralization of hydrogel biomaterials with calcium phosphate (CaP) is considered advantageous for bone regeneration. Mineralization can be both induced by the enzyme alkaline phosphatase (ALP) and promoted by calcium-binding biomolecules, such as plant-derived polyphenols. In this study, ALP-loaded gellan gum (GG) h...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21072315

    authors: Douglas TEL,Keppler JK,Vandrovcová M,Plencner M,Beranová J,Feuereisen M,Parakhonskiy BV,Svenskaya Y,Atkin V,Ivanova A,Ricquier P,Balcaen L,Vanhaecke F,Schieber A,Bačáková L,Skirtach AG

    更新日期:2020-03-27 00:00:00

  • Genome-Wide Organization and Expression Profiling of the SBP-Box Gene Family in Chinese Jujube (Ziziphus jujuba Mill.).

    abstract::Transcription factors play vital roles in the developmental processes of plants. The SQUAMOSA promoter binding protein (SBP) genes encode a family of plant-specific transcription factors and plays many crucial roles in plant development. In this study, 16 SBP-box gene family members were identified in Ziziphus jujuba ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18081734

    authors: Song S,Zhou H,Sheng S,Cao M,Li Y,Pang X

    更新日期:2017-08-15 00:00:00

  • Barley β-glucans-containing food enhances probiotic performances of beneficial bacteria.

    abstract::Currently, the majority of prebiotics in the market are derived from non-digestible oligosaccharides. Very few studies have focused on non-digestible long chain complex polysaccharides in relation to their potential as novel prebiotics. Cereals β-glucans have been investigated for immune-modulating properties and bene...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms15023025

    authors: Arena MP,Caggianiello G,Fiocco D,Russo P,Torelli M,Spano G,Capozzi V

    更新日期:2014-02-20 00:00:00

  • Homogenized finite element analysis on effective elastoplastic mechanical behaviors of composite with imperfect interfaces.

    abstract::A three-dimensional (3D) representative volume element (RVE) model was developed for analyzing effective mechanical behavior of fiber-reinforced ceramic matrix composites with imperfect interfaces. In the model, the fiber is assumed to be perfectly elastic until its tensile strength, and the ceramic material is modele...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms151223389

    authors: Jiang WG,Zhong RZ,Qin QH,Tong YG

    更新日期:2014-12-16 00:00:00

  • Fluence Rate Differences in Photodynamic Therapy Efficacy and Activation of Epidermal Growth Factor Receptor after Treatment of the Tumor-Involved Murine Thoracic Cavity.

    abstract::Photodynamic therapy (PDT) of the thoracic cavity can be performed in conjunction with surgery to treat cancers of the lung and its pleura. However, illumination of the cavity results in tissue exposure to a broad range of fluence rates. In a murine model of intrathoracic PDT, we studied the efficacy of 2-(1-hexyloxye...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms17010101

    authors: Grossman CE,Carter SL,Czupryna J,Wang L,Putt ME,Busch TM

    更新日期:2016-01-14 00:00:00

  • Gold Nanoparticles with Different Particle Sizes for the Quantitative Determination of Chlorpyrifos Residues in Soil by SERS.

    abstract::Chlorpyrifos (CPF) is widely used in the prevention and control of crop pests and diseases in agriculture. However, the irrational utilization of pesticides not only causes environmental pollution but also threatens human health. Compared with the conventional techniques for the determination of pesticides in soil, su...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20112817

    authors: He Y,Xiao S,Dong T,Nie P

    更新日期:2019-06-10 00:00:00

  • Low prostate concentration of lycopene is associated with development of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia.

    abstract::Prostate cancer (PC) is a frequent male malignancy and represents the second most diagnosed cancer in men. Since pre-cancerous lesions, i.e., the high-grade prostatic intraepithelial neoplasia (HGPIN), can be detected years before progression to PC, early diagnosis and chemoprevention are targeted strategies to reduce...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms15011433

    authors: Mariani S,Lionetto L,Cavallari M,Tubaro A,Rasio D,De Nunzio C,Hong GM,Borro M,Simmaco M

    更新日期:2014-01-21 00:00:00

  • Spike Activator 1, Encoding a bHLH, Mediates Axillary Bud Development and Spike Initiation in Phalaenopsis aphrodite.

    abstract::Double-spikes Phalaenopsis orchids have greater market value than those with single-spike. In this study, a gene designated as Spike Activator 1 (SPK1), which encodes a basic helix-loop-helix (bHLH) transcription factor, was isolated and characterized from Phalaenopsis aphrodite (moth orchid). SPK1 was highly expresse...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20215406

    authors: Lin YJ,Li MJ,Hsing HC,Chen TK,Yang TT,Ko SS

    更新日期:2019-10-30 00:00:00

  • Heterogeneous Network Model to Identify Potential Associations Between Plasmodium vivax and Human Proteins.

    abstract::Integration of multiple sources and data levels provides a great insight into the complex associations between human and malaria systems. In this study, a meta-analysis framework was developed based on a heterogeneous network model for integrating human-malaria protein similarities, a human protein interaction network...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21041310

    authors: Suratanee A,Plaimas K

    更新日期:2020-02-15 00:00:00

  • Genetic Risk Profiling in Parkinson's Disease and Utilizing Genetics to Gain Insight into Disease-Related Biological Pathways.

    abstract::Parkinson's disease (PD) is a complex disorder underpinned by both environmental and genetic factors. The latter only began to be understood around two decades ago, but since then great inroads have rapidly been made into deconvoluting the genetic component of PD. In particular, recent large-scale projects such as gen...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21197332

    authors: Hall A,Bandres-Ciga S,Diez-Fairen M,Quinn JP,Billingsley KJ

    更新日期:2020-10-04 00:00:00

  • Development of 101 gene-based single nucleotide polymorphism markers in sea cucumber, Apostichopus japonicus.

    abstract::Single nucleotide polymorphisms (SNPs) are currently the marker of choice in a variety of genetic studies. Using the high resolution melting (HRM) genotyping approach, 101 gene-based SNP markers were developed for Apostichopus japonicus, a sea cucumber species with economic significance for the aquaculture industry in...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms13067080

    authors: Du H,Bao Z,Yan J,Tian M,Mu X,Wang S,Lu W

    更新日期:2012-01-01 00:00:00

  • Role of GOLPH3 and TPX2 in Neuroblastoma DNA Damage Response and Cell Resistance to Chemotherapy.

    abstract::Neuroblastoma (NB) is an aggressive, relapse-prone infancy tumor of the sympathetic nervous system and is the leading cause of death among preschool age diseases, so the search for novel therapeutic targets is crucial. Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development, and in the DNA ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20194764

    authors: Ognibene M,Podestà M,Garaventa A,Pezzolo A

    更新日期:2019-09-25 00:00:00

  • Celebrating 25 Years of MicroRNA Research: From Discovery to Clinical Application.

    abstract::In 1993, the Ambros lab reported the cloning and developmental function of lin-4, the first microRNA [...]. ...

    journal_title:International journal of molecular sciences

    pub_type: 社论

    doi:10.3390/ijms20081987

    authors: Sempere LF

    更新日期:2019-04-23 00:00:00

  • Current Proceedings in the Molecular Dissection of Hepatocellular Adenomas: Review and Hands-on Guide for Diagnosis.

    abstract::Molecular dissection of hepatocellular adenomas has brought forward a diversity of well-defined entities. Their distinction is important for routine practice, since prognosis is tightly related to the individual subgroup. Very recent activity has generated new details on the molecular background of hepatocellular aden...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms160920994

    authors: Goltz D,Fischer HP

    更新日期:2015-09-02 00:00:00

  • Enhanced production of a novel cyclic hexapeptide antibiotic (NW-G01) by Streptomyces alboflavus 313 using response surface methodology.

    abstract::NW-G01, produced by Streptomyces alboflavus 313, is a novel cyclic hexapeptide antibiotic with many potential applications, including antimicrobial activity and antitumor agents. This study developed a system for optimizing medium components in order to enhance NW-G01 production. In this study, Plackett-Burman design ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms13045230

    authors: Guo Z,Shen L,Ji Z,Wu W

    更新日期:2012-01-01 00:00:00

  • BCL11A mRNA Targeting by miR-210: A Possible Network Regulating γ-Globin Gene Expression.

    abstract::The involvement of microRNAs in the control of repressors of human γ-globin gene transcription has been firmly demonstrated, as described for the miR-486-3p mediated down-regulation of BCL11A. On the other hand, we have reported that miR-210 is involved in erythroid differentiation and, possibly, in γ-globin gene up-r...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18122530

    authors: Gasparello J,Fabbri E,Bianchi N,Breveglieri G,Zuccato C,Borgatti M,Gambari R,Finotti A

    更新日期:2017-11-26 00:00:00

  • HGF/c-MET: A Promising Therapeutic Target in the Digestive System Cancers.

    abstract::The HGF/c-MET pathway is active in the development of digestive system cancers, indicating that inhibition of HGF/c-MET signaling may have therapeutic potential. Various HGF/c-MET signaling inhibitors, mainly c-MET inhibitors, have been tested in clinical trials. The observed efficacy and adverse events of some c-MET ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19113295

    authors: Zhang H,Feng Q,Chen WD,Wang YD

    更新日期:2018-10-23 00:00:00

  • Pharmacological Chaperones: A Therapeutic Approach for Diseases Caused by Destabilizing Missense Mutations.

    abstract::The term "pharmacological chaperone" was introduced 20 years ago. Since then the approach with this type of drug has been proposed for several diseases, lysosomal storage disorders representing the most popular targets. The hallmark of a pharmacological chaperone is its ability to bind a protein specifically and stabi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21020489

    authors: Liguori L,Monticelli M,Allocca M,Hay Mele B,Lukas J,Cubellis MV,Andreotti G

    更新日期:2020-01-13 00:00:00

  • Vortioxetine Subchronically Activates Serotonergic Transmission via Desensitization of Serotonin 5-HT1A Receptor with 5-HT3 Receptor Inhibition in Rats.

    abstract::Vortioxetine is a novel, multimodal antidepressant with unique targets, including the inhibition of the serotonin transporter (SET), of serotonin 5-HT3 (5-HT3R), and of 5-HT7 (5-HT7R) receptors and partial agonism to serotonin 5-HT1A (5-HT1AR) receptors in humans. Vortioxetine has a lower affinity to 5-HT1AR and 5-HT7...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20246235

    authors: Okada M,Okubo R,Fukuyama K

    更新日期:2019-12-10 00:00:00

  • Real-Time 3D Imaging and Inhibition Analysis of Various Amyloid Aggregations Using Quantum Dots.

    abstract::Amyloidosis refers to aggregates of protein that accumulate and are deposited as amyloid fibrils into plaques. When these are detected in organs, they are the main hallmark of Alzheimer's disease, Parkinson's disease, and other related diseases. Recent medical advances have shown that many precursors and proteins can ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21061978

    authors: Lin X,Galaqin N,Tainaka R,Shimamori K,Kuragano M,Noguchi TQP,Tokuraku K

    更新日期:2020-03-13 00:00:00

  • Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study.

    abstract::In the present study, we evaluated tumor-infiltrating lymphocytes (TILs) and blood regulatory T lymphocyte (Tregs, CD4+/CD25+/FoxP3+) expression in bladder cancer patients. The number of CD4+, CD8+, CD25+, FoxP3+ and CD20+ TILs was analyzed in association with clinico-pathomorphological features. In more advanced meta...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms17030285

    authors: Jóźwicki W,Brożyna AA,Siekiera J,Slominski AT

    更新日期:2016-02-25 00:00:00

  • Trypanosoma brucei Interaction with Host: Mechanism of VSG Release as Target for Drug Discovery for African Trypanosomiasis.

    abstract::The protozoan Trypanosoma brucei, responsible for animal and human trypanosomiasis, has a family of major surface proteases (MSPs) and phospholipase-C (PLC), both involved in some mechanisms of virulence during mammalian infections. During parasitism in the mammalian host, this protozoan is exclusively extracellular a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20061484

    authors: Moreno CJG,Temporão A,Torres T,Sousa Silva M

    更新日期:2019-03-25 00:00:00

  • Histone Deacetylase (HDAC) Gene Family in Allotetraploid Cotton and Its Diploid Progenitors: In Silico Identification, Molecular Characterization, and Gene Expression Analysis under Multiple Abiotic Stresses, DNA Damage and Phytohormone Treatments.

    abstract::Histone deacetylases (HDACs) play a significant role in a plant's development and response to various environmental stimuli by regulating the gene transcription. However, HDACs remain unidentified in cotton. In this study, a total of 29 HDACs were identified in allotetraploid Gossypium hirsutum, while 15 and 13 HDACs ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21010321

    authors: Imran M,Shafiq S,Naeem MK,Widemann E,Munir MZ,Jensen KB,Wang RR

    更新日期:2020-01-03 00:00:00

  • Glycemic variability and oxidative stress: a link between diabetes and cardiovascular disease?

    abstract::Diabetes is associated with a two to three-fold increase in risk of cardiovascular disease. However, intensive glucose-lowering therapy aiming at reducing HbA1c to a near-normal level failed to suppress cardiovascular events in recent randomized controlled trials. HbA1c reflects average glucose level rather than glyce...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms151018381

    authors: Saisho Y

    更新日期:2014-10-13 00:00:00