Abstract：
:HD-Zip proteins are unique to plants, and contain a homeodomain closely linked to a leucine zipper motif, which are involved in dimerization and DNA binding. Based on homology in the HD-Zip domain, gene structure and the presence of additional motifs, HD-Zips are divided into four families, HD-Zip I⁻IV. Phylogenetic analysis of HD-Zip genes using transcriptomic and genomic datasets from a wide range of plant species indicate that the HD-Zip protein class was already present in green algae. Later, HD-Zips experienced multiple duplication events that promoted neo- and sub-functionalizations. HD-Zip proteins are known to control key developmental and environmental responses, and a growing body of evidence indicates a strict link between members of the HD-Zip II and III families and the auxin machineries. Interactions of HD-Zip proteins with other hormones such as brassinolide and cytokinin have also been described. More recent data indicate that members of different HD-Zip families are directly involved in the regulation of abscisic acid (ABA) homeostasis and signaling. Considering the fundamental role of specific HD-Zip proteins in the control of key developmental pathways and in the cross-talk between auxin and cytokinin, a relevant role of these factors in adjusting plant growth and development to changing environment is emerging.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Sessa G,Carabelli M,Possenti M,Morelli G,Ruberti Idoi
10.3390/ijms19124047subject
Has Abstractpub_date
2018-12-14 00:00:00issue
12issn
1422-0067pii
ijms19124047journal_volume
19pub_type
杂志文章,评审abstract：:Generally, the prevalence of epilepsy does not exceed 0.9% of the population and approximately 70% of epilepsy patients may be adequately controlled with antiepileptic drugs (AEDs). Moreover, status epilepticus (SE) or even a single seizure may produce neurodegeneration within the brain and SE has been recognized as o...
journal_title：International journal of molecular sciences
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更新日期：2020-03-28 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-02-07 00:00:00
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更新日期：2021-01-09 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2010-09-21 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-03-25 00:00:00
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更新日期：2017-12-07 00:00:00
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更新日期：2017-05-06 00:00:00
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更新日期：2020-04-18 00:00:00
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更新日期：2020-10-03 00:00:00
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更新日期：2018-04-24 00:00:00
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