Abstract：
:Enhancer of zeste homolog 2 (EZH2) plays critical roles in a range of biological processes including organ development and homeostasis, epigenomic and transcriptomic regulation, gene repression and imprinting, and DNA damage repair. A widely known function of EZH2 is to serve as an enzymatic subunit of Polycomb repressive complex 2 (PRC2) and catalyze trimethylation of histone H3 lysine 27 (H3K27me3) for repressing target gene expression. However, an increasing body of evidence demonstrates that EZH2 has many "non-conventional" functions that go beyond H3K27 methylation as a Polycomb factor. First, EZH2 can methylate a number of nonhistone proteins, thereby regulating cellular processes in an H3K27me3-independent fashion. Furthermore, EZH2 relies on both methyltransferase-dependent and methyltransferase-independent mechanisms for modulating gene-expression programs and/or epigenomic patterns of cells. Importantly, independent of PRC2, EZH2 also forms physical interactions with a number of DNA-binding factors and transcriptional coactivators to context-dependently influence gene expression. The purpose of this review is to detail the complex, noncanonical roles of EZH2, which are generally less appreciated in gene and (epi)genome regulation. Because EZH2 deregulation is prevalent in human diseases such as cancer, there is increased dependency on its noncanonical function, which shall have important implications in developing more effective therapeutics.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Wang J,Wang GGdoi
10.3390/ijms21249501subject
Has Abstractpub_date
2020-12-14 00:00:00issue
24issn
1422-0067pii
ijms21249501journal_volume
21pub_type
杂志文章,评审abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease. In this study, to investigate the effect of microglial elimination on AD progression, we administered PLX3397, a selective colony-stimulating factor 1 receptor inhibitor, to the mouse model of AD (5xFAD mice). Amyloid-beta (Aβ) deposition and amyloid...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-08-03 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms19124004
更新日期：2018-12-12 00:00:00
abstract：:Mantle cell lymphoma (MCL) is a heterogeneous malignancy with a broad spectrum of clinical behavior from indolent to highly aggressive cases. Despite the fact that MCL remains in most cases incurable by currently applied immunochemotherapy, our increasing knowledge on the biology of MCL in the last two decades has led...
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更新日期：2019-09-08 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2018-01-21 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-01-15 00:00:00
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更新日期：2020-04-27 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-12-07 00:00:00
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更新日期：2020-09-21 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-08-21 00:00:00
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更新日期：2020-03-20 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17111877
更新日期：2016-11-10 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-02-18 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2017-12-15 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2017-05-08 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-10-27 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-01-03 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-11-30 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2015-07-08 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2017-08-19 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-05-05 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-03-12 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-06-06 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2013-11-20 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-02-28 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2019-03-29 00:00:00
