Abstract：
:The kidney is innervated by afferent sensory and efferent sympathetic nerve fibers. Norepinephrine (NE) is the primary neurotransmitter for post-ganglionic sympathetic adrenergic nerves, and its signaling, regulated through adrenergic receptors (AR), modulates renal function and pathophysiology under disease conditions. Renal sympathetic overactivity and increased NE level are commonly seen in chronic kidney disease (CKD) and are critical factors in the progression of renal disease. Blockade of sympathetic nerve-derived signaling by renal denervation or AR blockade in clinical and experimental studies demonstrates that renal nerves and its downstream signaling contribute to progression of acute kidney injury (AKI) to CKD and fibrogenesis. This review summarizes our current knowledge of the role of renal sympathetic nerve and adrenergic receptors in AKI, AKI to CKD transition and CKDand provides new insights into the therapeutic potential of intervening in its signaling pathways.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Noh MR,Jang HS,Kim J,Padanilam BJdoi
10.3390/ijms21051647subject
Has Abstractpub_date
2020-02-28 00:00:00issue
5issn
1422-0067pii
ijms21051647journal_volume
21pub_type
杂志文章,评审abstract：:Myostatin is a negative regulator of muscle cell growth and proliferation. Furthermore, myostatin directly affects the expression of 14q32 microRNAs by binding the 14q32 locus. Direct inhibition of 14q32 microRNA miR-495-3p decreased postinterventional restenosis via inhibition of both vascular smooth muscle cell (VSM...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2015-11-24 00:00:00
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更新日期：2019-09-20 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-09-09 00:00:00
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更新日期：2011-01-01 00:00:00
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更新日期：2019-07-20 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-09-04 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-06-23 00:00:00
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journal_title：International journal of molecular sciences
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