Abstract：
:G protein-coupled receptors (GPCRs) have a substantial role in tumorigenesis and are described as a "cancer driver". Aberrant expression or activation of GPCRs leads to the deregulation of downstream signaling pathways, thereby promoting cancer progression. In hepatocellular carcinoma (HCC), the Wnt signaling pathway is frequently activated and it is associated with an aggressive HCC phenotype. Frizzled (FZD) receptors, a family member of GPCRs, are known to mediate Wnt signaling. Accumulating findings have revealed the deregulation of FZD receptors in HCC and their functional roles have been implicated in HCC progression. Given the important role of FZD receptors in HCC, we summarize here the expression pattern of FZD receptors in HCC and their corresponding functional roles during HCC progression. We also further review and highlight the potential targeting of FZD receptors as an alternative therapeutic strategy in HCC.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Chan KK,Lo RCdoi
10.3390/ijms19010313subject
Has Abstractpub_date
2018-01-21 00:00:00issue
1issn
1422-0067pii
ijms19010313journal_volume
19pub_type
杂志文章,评审abstract：:The analysis of saliva as a diagnostic approach for systemic diseases was proposed just two decades ago, but recently great interest in the field has emerged because of its revolutionary potential as a liquid biopsy and its usefulness as a non-invasive sampling method. Multiple molecules isolated in saliva have been p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17091531
更新日期：2016-09-12 00:00:00
abstract：:SDS-gradient mini-gel electrophoresis and immunoblotting of urine of rats given ochratoxin A (OTA), showed OTA binding to an alpha2u-globulin. Perceived potential internalised delivery of OTA to proximal tubule epithelia by the carrier, specific only to adult male rats and augmenting other uptake mechanisms, suggests ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9050719
更新日期：2008-05-01 00:00:00
abstract：:Hemophilia A (HA) is associated with defects in the F8 gene, encoding coagulation factor VIII (FVIII). Our previous studies show that F8-targeting micro RNAs (miRNAs), a group of small RNAs involved in gene regulation, can downregulate F8 expression causing HA in individuals with normal F8-genotypes and increased HA s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165621
更新日期：2020-08-06 00:00:00
abstract：:In clinical practice, the metabolic syndrome can lead to multiple complications, including diabetes. It remains unclear which component of the metabolic syndrome (obesity, inflammation, hyperglycemia, or insulin resistance) has the strongest inhibitory effect on stem cells involved in beta cell regeneration. This make...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030991
更新日期：2020-02-03 00:00:00
abstract：:Glutamine synthetase 2 (GS2) is a key enzyme involved in the ammonium metabolism in plant leaves. In our previous study, we obtained GS2-cosuppressed plants, which displayed a normal growth phenotype at the seedling stage, while at the tillering stage they showed a chlorosis phenotype. In this study, to investigate th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160612713
更新日期：2015-06-04 00:00:00
abstract：:Because angiogenesis is a major contributor to cancer progression and metastasis, it is an attractive target for cancer therapy. Although a diverse number of small compounds for anti-angiogenic therapy have been developed, severe adverse effects commonly occur, since small compounds can affect not only tumor endotheli...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20235819
更新日期：2019-11-20 00:00:00
abstract：:Alternatively translated from the ENO gene and expressed in an array of vertebrate and plant tissues, c-Myc binding protein 1 (MBP-1) participates in the regulation of growth in organisms, their development and their environmental responses. As a transcriptional repressor of multiple proto-oncogenes, vertebrate MBP-1 ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19123868
更新日期：2018-12-04 00:00:00
abstract：:Tumor necrosis factor receptor-associated factor 6 (TRAF6), a unique E3 ubiquitin ligase and adaptor protein, is involved in activation of various signaling cascades. Recent studies identify TRAF6 as one of the novel regulators of skeletal muscle atrophy. The role of TRAF6 in glucocorticoid-induced muscle atrophy, how...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150611126
更新日期：2014-06-20 00:00:00
abstract：:Exceptionally long-lived individuals (ELLI) who are the focus of many healthy longevity studies around the globe are now being studied in Israel. The Israeli Multi-Ethnic Centenarian Study (IMECS) cohort is utilized here for assessment of various DNA methylation clocks. Thorough phenotypic characterization and whole b...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020615
更新日期：2020-01-17 00:00:00
abstract：:As key cellular elements of hemostasis, platelets represent a primary target for thrombosis and bleeding management. Currently, therapeutic manipulations of platelet function (antithrombotic drugs) and count (platelet transfusion) are performed with limited or no real-time monitoring of the desired outcome at the poin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041174
更新日期：2020-02-11 00:00:00
abstract：:Response surface methodology (RSM) was employed to optimize the extracellular lipase production by Burkholderia sp. HL-10. Preliminary tests showed that olive oil, tryptone and Tween-80 exhibited significant effects on the lipase production. The optimum concentrations of these three components were determined using a ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms131114889
更新日期：2012-11-13 00:00:00
abstract：:Our laboratory and others previously showed that Annexin A2 knockout (A2KO) mice had impaired blood-brain barrier (BBB) development and elevated pro-inflammatory response in macrophages, implying that Annexin A2 (AnxA2) might be one of the key endogenous factors for maintaining homeostasis of the neurovascular unit in...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246125
更新日期：2019-12-05 00:00:00
abstract：:Higher prevalence of neurodegenerative diseases is strictly connected with progressive aging of the world population. Interestingly, a broad range of age-related, neurodegenerative diseases is characterized by a common pathological mechanism-accumulation of misfolded and unfolded proteins within the cells. Under certa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21062108
更新日期：2020-03-19 00:00:00
abstract：:Protein folding, misfolding and aggregation, as well as the way misfolded and aggregated proteins affects cell viability are emerging as key themes in molecular and structural biology and in molecular medicine. Recent advances in the knowledge of the biophysical basis of protein folding have led to propose the energy ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9122515
更新日期：2008-12-01 00:00:00
abstract：:The progressive decline of the nervous system, including protein aggregate formation, reflects the subtle dysregulation of multiple functional pathways. Our previous work has shown intermittent fasting (IF) enhances longevity, maintains adult behaviors and reduces aggregates, in part, by promoting autophagic function ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19041140
更新日期：2018-04-10 00:00:00
abstract：:This narrative review aims to summarize the current controversy on the balance between ethanol and phytochemicals in wine, focusing on light drinking and oral cancer. Extensive literature search included PUBMED and EMBASE databases to identify in human studies and systematic reviews (up to March 2015), which contribut...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms160817029
更新日期：2015-07-27 00:00:00
abstract：:The inducible expression of the mitochondrial translocator protein 18 kDa (TSPO) by activated microglia is a prominent, regular feature of acute and chronic-progressive brain pathology. This expression is also the rationale for the continual development of new TSPO binding molecules for the diagnosis of "neuroinflamma...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092707
更新日期：2018-09-11 00:00:00
abstract：:Metastatic renal cell carcinoma (RCC) remains an important clinical issue; the 5-year survival rate of patients with metastasis is approximately 12%, while it is 93% in those with localized disease. There is evidence that blood cadmium and lead levels are elevated in RCC. The current studies were designed to assess th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246315
更新日期：2019-12-14 00:00:00
abstract：:Placental homeostasis of tryptophan is essential for fetal development and programming. The two main metabolic pathways (serotonin and kynurenine) produce bioactive metabolites with immunosuppressive, neurotoxic, or neuroprotective properties and their concentrations in the fetoplacental unit must be tightly regulated...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207578
更新日期：2020-10-14 00:00:00
abstract：:The translocator protein (TSPO), located at the outer mitochondrial membrane (OMM), serves multiple functions and contributes to numerous processes, including cholesterol import, mitochondrial metabolism, apoptosis, cell proliferation, Ca2+ signaling, oxidative stress, and inflammation. TSPO forms a complex with the v...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20133348
更新日期：2019-07-08 00:00:00
abstract：:Adipose-derived mesenchymal stem cells (ASCs) are well known for their secretory potential, which confers them useful properties in cell therapy. Nevertheless, this therapeutic potential is reduced after transplantation due to their short survival in the human body and their migration property. This study proposes a m...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176316
更新日期：2020-08-31 00:00:00
abstract：:Quantification of gene expression is crucial to connect genome sequences with phenotypic and physiological data. RNA-Sequencing (RNA-Seq) has taken a prominent role in the study of transcriptomic reactions of plants to various environmental and genetic perturbations. However, comparative tests of different tools for R...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051720
更新日期：2020-03-03 00:00:00
abstract：:In this study, the potential bioactivities of Portuguese oyster (Crassostrea angulata) proteins were predicted through in silico analyses and confirmed by in vitro tests. C. angulata proteins were characterized by sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and identified by proteomics techni...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205191
更新日期：2019-10-20 00:00:00
abstract：:Accumulating evidence indicates that oxidative stress plays a critical role in initiating the progression of inflammatory and fibrotic liver diseases, including cholestatic hepatitis. Peroxiredoxin 4 (PRDX4) is a secretory antioxidase that protects against oxidative damage by scavenging reactive oxygen species (ROS) i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092509
更新日期：2018-08-24 00:00:00
abstract：:Winter's advent invokes physiological adjustments that permit temperate ectotherms to cope with stresses such as food shortage, water deprivation, hypoxia, and hypothermia. We used liquid chromatography (LC) in combination with tandem mass spectrometry (MS/MS) quantitative isobaric (iTRAQ™) peptide mapping to assess v...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12128406
更新日期：2011-01-01 00:00:00
abstract：:Prenatal smoke exposure (PreSE) is a risk factor for nicotine dependence, which is further enhanced by postnatal smoke exposure (PostSE). One susceptibility gene to nicotine dependence is Cytochrome P450 (CYP) 2A6, an enzyme responsible for the conversion of nicotine to cotinine in the liver. Higher CYP2A6 activity is...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010164
更新日期：2020-12-26 00:00:00
abstract：:In the absence of lymphatics, fluid and solutes such as amyloid-β (Aβ) are eliminated from the brain along basement membranes in the walls of cerebral capillaries and arteries-the Intramural Peri-Arterial Drainage (IPAD) pathway. IPAD fails with age and insoluble Aβ is deposited as plaques in the brain and in IPAD pat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041225
更新日期：2020-02-12 00:00:00
abstract：:The molecular mechanism regulating embryo development under reduced oxygen tension remains elusive. This study aimed to identify the molecular mechanism impacting embryo development under low oxygen conditions. Buffalo embryos were cultured under 5% or 20% oxygen and were evaluated according to their morphological par...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21061996
更新日期：2020-03-14 00:00:00
abstract：:The use of nanotechnology could play a significant role in the agriculture sector, especially in the preparation of new-generation agronanochemicals. Currently, the economically important plant of Malaysia, the oil palm, faces the threat of a devastating disease which is particularly caused by a pathogenic fungus, Gan...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092247
更新日期：2019-05-07 00:00:00
abstract：:Sema3C protein, a member of the class 3 family of secreted semaphorins, play an important role in tumor development by regulating cell proliferation, migration, invasion, and angiogenesis processes. Depending on the type and malignancy grade of the tumor, Sema3C function remains controversial. In this study, we constr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20225672
更新日期：2019-11-12 00:00:00
