Abstract:
:In clinical practice, the metabolic syndrome can lead to multiple complications, including diabetes. It remains unclear which component of the metabolic syndrome (obesity, inflammation, hyperglycemia, or insulin resistance) has the strongest inhibitory effect on stem cells involved in beta cell regeneration. This makes it challenging to develop effective treatment options for complications such as diabetes. In our study, experiments were performed on male C57BL/6 mice where metabolic disorders have been introduced experimentally by a combination of streptozotocin-treatment and a high-fat diet. We evaluated the biological effects of Bisamide Derivative of Dicarboxylic Acid (BDDA) and its impact on pancreatic stem cells in vivo. To assess the impact of BDDA, we applied a combination of histological and biochemical methods along with a cytometric analysis of stem cell and progenitor cell markers. We show that in mice with metabolic disorders, BDDA has a positive effect on lipid and glucose metabolism. The pancreatic restoration was associated with a decrease of the inhibitory effects of inflammation and obesity factors on pancreatic stem cells. Our data shows that BDDA increases the number of pancreatic stem cells. Thus, BDDA could be used as a new compound for treating complication of the metabolic syndrome such as diabetes.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Vladimirovna Pakhomova A,Nebolsin VE,Victorovna Pershina O,Andreevich Krupin V,Alexandrovna Sandrikina L,Sergeevich Pan E,Nicolaevna Ermakova N,Evgenevna Vaizova O,Widera D,Grimm WD,Yur'evich Kravtsov V,Alexandrovich Afanasiev S,doi
10.3390/ijms21030991subject
Has Abstractpub_date
2020-02-03 00:00:00issue
3issn
1422-0067pii
ijms21030991journal_volume
21pub_type
杂志文章abstract::Before utilization in biomedical diagnosis, therapeutic treatment, and biotechnology, the diverse variety of peptides and proteins must be preliminarily purified and thoroughly characterized. The recombinant DNA technology and heterologous protein expression have helped simplify the isolation of targeted polypeptides ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21030928
更新日期:2020-01-31 00:00:00
abstract::Bradysia odoriphaga (Diptera: Sciaridae) is the most important pest of Chinese chive. Insecticides are used widely and frequently to control B. odoriphaga in China. However, the performance of the insecticides chlorpyrifos and clothianidin in controlling the Chinese chive maggot is quite different. Using next generati...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18112445
更新日期:2017-11-17 00:00:00
abstract::Kombucha tea (KT) has emerged as a substance that protects the liver from damage; however, its mechanisms of action on the fatty liver remain unclear. Therefore, we investigated the potential role of KT and its underlying mechanisms on nonalcoholic fatty liver disease (NAFLD). db/db mice that were fed methionine/choli...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20092369
更新日期:2019-05-13 00:00:00
abstract::The scanning speed of atomic force microscopes continues to advance with some current commercial microscopes achieving on the order of one frame per second and at least one reaching 10 frames per second. Despite the success of these instruments, even higher frame rates are needed with scan ranges larger than are curre...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19041044
更新日期:2018-03-31 00:00:00
abstract::Myostatin is a negative regulator of muscle cell growth and proliferation. Furthermore, myostatin directly affects the expression of 14q32 microRNAs by binding the 14q32 locus. Direct inhibition of 14q32 microRNA miR-495-3p decreased postinterventional restenosis via inhibition of both vascular smooth muscle cell (VSM...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21103508
更新日期:2020-05-15 00:00:00
abstract::A specific oligodeoxynucleotide (ODN), ODN MT01, was found to have positive effects on the proliferation and activation of the osteoblast-like cell line MG 63. In this study, the detailed signaling pathways in which ODN MT01 promoted the differentiation of osteoblasts were systematically examined. ODN MT01 enhanced th...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13077902
更新日期:2012-01-01 00:00:00
abstract::Neurodegenerative disorders can induce modifications of several proteins; one of which is ceruloplasmin (Cp), a ferroxidase enzyme found modified in the cerebrospinal fluid (CSF) of neurodegenerative diseases patients. Cp modifications are caused by the oxidation induced by the pathological environment and are usually...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms22020663
更新日期:2021-01-11 00:00:00
abstract::Chlorpyrifos (CPF) is widely used in the prevention and control of crop pests and diseases in agriculture. However, the irrational utilization of pesticides not only causes environmental pollution but also threatens human health. Compared with the conventional techniques for the determination of pesticides in soil, su...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20112817
更新日期:2019-06-10 00:00:00
abstract::DUSP6 is a dual-specificity phosphatase (DUSP) involved in breast cancer progression, recurrence, and metastasis. DUSP6 is predominantly cytoplasmic in HER2+ primary breast cancer cells, but the expression and subcellular localization of DUSPs, especially DUSP6, in HER2-positive circulating tumor cells (CTCs) is unkno...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20123080
更新日期:2019-06-24 00:00:00
abstract::The life of any living organism can be defined as a hurdle due to different kind of stresses. As with all living organisms, plants are exposed to various abiotic stresses, such as drought, salinity, extreme temperatures and chemical toxicity. These primary stresses are often interconnected, and lead to the overproduct...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms13044458
更新日期:2012-01-01 00:00:00
abstract::Hibernation is an effective energy conservation strategy that has been widely adopted by animals to cope with unpredictable environmental conditions. The liver, in particular, plays an important role in adaptive metabolic adjustment during hibernation. Mammalian studies have revealed that many genes involved in metabo...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19082363
更新日期:2018-08-10 00:00:00
abstract::Neonatal seizures are one of the most common comorbidities of neonatal encephalopathy, with seizures aggravating acute injury and clinical outcomes. Current treatment can control early life seizures; however, a high level of pharmacoresistance remains among infants, with increasing evidence suggesting current anti-sei...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21217832
更新日期:2020-10-22 00:00:00
abstract::Reactive Oxygen Species or "ROS" encompass several molecules derived from oxygen that can oxidize other molecules and subsequently transition rapidly between species. The key roles of ROS in biological processes are cell signaling, biosynthetic processes, and host defense. In cancer cells, increased ROS production and...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21093100
更新日期:2020-04-28 00:00:00
abstract::Ceramide and diacylglycerol are linked to insulin resistance in rodents, but in humans the data are inconsistent. Insulin resistance is frequently observed with aging, but the role of ceramide and diacylglycerol is not clarified. Training improves metabolic health and, therefore, we aimed to elucidate the influence of...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20051240
更新日期:2019-03-12 00:00:00
abstract::Cell proliferation is an important biological process during myogenesis. Tob1 encoded a member of the Tob/BTG family of anti-proliferative proteins. Our previous LongSAGE (Long Serial Analysis of Gene Expression) analysis suggested that Tob1 was differentially expressed during prenatal skeletal muscle development. In ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms12074315
更新日期:2011-01-01 00:00:00
abstract::Bacteria generate membrane vesicles, which are structures known as extracellular vesicles (EVs), reported to be involved in different pathogenic mechanisms, as it has been demonstrated that EVs participate in biofilm formation, cell-to-cell communication, bacteria-host interactions, and nutrients supply. EVs deliver n...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20215307
更新日期:2019-10-25 00:00:00
abstract::The ATP-sensitive K+ channel (KATP) is involved in hypersensitivity during chronic pain and is presumed to be a downstream target of mu opioid receptors. Multiple subtypes of KATP channels exist in the peripheral and central nervous system and their activity may be inversely correlated to chronic pain phenotypes in ro...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20092251
更新日期:2019-05-07 00:00:00
abstract::Retinoids exert antitumor effects through the retinoic acid receptor α (RARα). In the present study, we sought to identify the factors involved in the RARα-mediated transcriptional regulation of the tumor suppressor gene and the tissue factor pathway inhibitor 2 (TFPI2) in hepatocellular carcinoma (H...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19051450
更新日期:2018-05-13 00:00:00
abstract::The epiphyseal plate is a hyaline cartilage plate that sits between the diaphysis and the epiphysis. The objective of this study was to determine the impact of an injury in the growth plate chondrocytes through the study of histological morphology, immunohistochemistry, histomorphometry and Western Blot analyses of th...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms140815767
更新日期:2013-07-29 00:00:00
abstract::Alzheimer's disease (AD) is a leading cause of dementia worldwide, associated with cognitive deficits and brain glucose metabolic alteration. However, the associations of glucose metabolic changes with cognitive dysfunction are less detailed. Here, we examined the brains of APP/presenilin 1 (PS1) transgenic (Tg) mice ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17101707
更新日期:2016-10-18 00:00:00
abstract::The WRKY web, which is comprised of a subset of WRKY transcription factors (TFs), plays a crucial role in the regulation of plant immunity, however, the mode of organization and operation of this network remains obscure, especially in non-model plants such as pepper (Capsicum annuum). Herein, CaWRKY22, a member of a s...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19051426
更新日期:2018-05-10 00:00:00
abstract::Ascorbate oxidase (AO) plays important roles in plant growth and development. Previously, we reported a cotton AO gene that acts as a positive factor in cell growth. Investigations on Gossypium hirsutum AO (GhAO) family genes and their multiple functions are limited. The present study identified eight GhAO family gene...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20246167
更新日期:2019-12-06 00:00:00
abstract::Parathyroid hormone-related protein (PTHrP), with isoforms ranging from 139 to 173 amino acids, has long been implicated in the development and regulation of multiple tissues, including that of the skeleton, via paracrine and autocrine signaling. PTHrP is also known as a potent mediator of cancer-induced bone disease,...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20112814
更新日期:2019-06-08 00:00:00
abstract::In eukaryotes, DNA is compacted into a complex structure known as chromatin. The unravelling of DNA is a crucial step in DNA repair, replication, transcription and recombination as this allows access to DNA for these processes. Failure to package DNA into the nucleosome, the individual unit of chromatin, can lead to g...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms12118063
更新日期:2011-01-01 00:00:00
abstract::Autophagy is an essential mechanism to maintain cellular homeostasis. Besides its role in controlling the quality of cytoplasmic components, it participates in nutrient obtaining and lipid mobilization under stressful conditions. Furthermore, autophagy is involved in the regulation of systemic metabolism as its blocka...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21072479
更新日期:2020-04-03 00:00:00
abstract::Autophagy (particularly macroautophagy) is a bulk degradation process used by eukaryotic cells in order to maintain adequate energy levels and cellular homeostasis through the delivery of long-lived proteins and organelles to the lysosome, resulting in their degradation. It is becoming increasingly clear that many of ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20163916
更新日期:2019-08-12 00:00:00
abstract::Inflammation is the body's response to injury or infection. As early as 2000 years ago, the Roman encyclopaedist Aulus Cornelius Celsus recognised four cardinal signs of this response-redness, heat, swelling and pain; a fifth sign is loss of function.[...]. ...
journal_title:International journal of molecular sciences
pub_type: 社论
doi:10.3390/ijms18112415
更新日期:2017-11-14 00:00:00
abstract::Cystic fibrosis (CF) is caused by mutations in the gene encoding the transmembrane conductance regulator (CFTR) protein. Some CF patients are compound heterozygous or homozygous for nonsense mutations in the CFTR gene. This implies the presence in the transcript of premature termination codons (PTCs) responsible for a...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21134781
更新日期:2020-07-06 00:00:00
abstract::Previous studies have shown that germin-like proteins (GLPs) are present ubiquitously in rice and Arabidopsis. However, the understanding regarding their role in development and abiotic/biotic stress resistance remains limited. In the present study, we report genome-wide identification, characterisation, subcellular l...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17101622
更新日期:2016-09-23 00:00:00
abstract::The mosquito-borne viral disease caused by the Dengue virus is an expanding global threat. Diagnosis in low-resource-settings and epidemiological surveillance urgently requires new immunoprobes for serological tests. Structure-based epitope prediction is an efficient method to design diagnostic peptidic probes able to...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20081921
更新日期:2019-04-18 00:00:00