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Nuclear-Biased DUSP6 Expression is Associated with Cancer Spreading Including Brain Metastasis in Triple-Negative Breast Cancer.

Abstract：

:DUSP6 is a dual-specificity phosphatase (DUSP) involved in breast cancer progression, recurrence, and metastasis. DUSP6 is predominantly cytoplasmic in HER2+ primary breast cancer cells, but the expression and subcellular localization of DUSPs, especially DUSP6, in HER2-positive circulating tumor cells (CTCs) is unknown. Here we used the DEPArray system to identify and isolate CTCs from metastatic triple negative breast cancer (TNBC) patients and performed single-cell NanoString analysis to quantify cancer pathway gene expression in HER2-positive and HER2-negative CTC populations. All TNBC patients contained HER2-positive CTCs. HER2-positive CTCs were associated with increased ERK1/ERK2 expression, which are direct DUSP6 targets. DUSP6 protein expression was predominantly nuclear in breast CTCs and the brain metastases but not pleura or lung metastases of TNBC patients. Therefore, nuclear DUSP6 may play a role in the association with cancer spreading in TNBC patients, including brain metastasis.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Wu F,McCuaig RD,Sutton CR,Tan AHY,Jeelall Y,Bean EG,Dai J,Prasanna T,Batham J,Malik L,Yip D,Dahlstrom JE,Rao S

doi

10.3390/ijms20123080

subject

Has Abstract

pub_date

2019-06-24 00:00:00

issue

12

issn

1422-0067

pii

ijms20123080

journal_volume

20

pub_type

杂志文章

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